Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"terpene synthases"”.
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Head-to-head terpene synthases: Mechanism of action and inhibition
“Head-to-head” terpene synthases catalyze the first committed steps in sterol and carotenoid biosynthesis: the condensation of two isoprenoid diphosphates to form cyclopropylcarbinyl diphosphates, followed by ring opening. In this work, I used x-ray crystallography, and mutagenesis to study the …
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The Origins of Terpene Infochemicals in Insects: Identification and Evolutionary Analysis of Terpene Synthases in Diverse Lineages
… abundant class of specialized metabolites are terpenes, which are released by many members of taxonomically diverse insect lineages as pheromone and defense compounds. Despite the broad occurrence of terpenes in insects, knowledge of their biosynthesis remains limited compared to that in other …
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NMR, Crystallographic and Computational Investigations of Peptides, Proteins and Bisphosphonates: New Paradigms for Rational Drug Design
… catalytic mechanisms and evolutionary origins of terpene synthases and cyclases, and finally (3) developing mathematical models based on enzyme-inhibition data and molecular descriptors to predict potency/activity of compounds in cell-based assays."
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Identification and Functional Characterization of Sesquiterpene Pheromone Biosynthetic Genes in Stink Bugs (Pentatomidae)
… provide evidence that Pentatomidae produce sesquiterpene aggregation pheromones de novo and discuss the evolution of terpene biosynthesis in stink bugs. According to transcriptome analyses, the investigated stink bug species express at least two isoprenyl diphosphate synthases (IDSs), one of which …
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Aggregation Pheromone Biosynthesis and Engineering in Plants for Stinkbug Pest Management
… pest on crucifer crops, produces the sesquiterpene, murgantiol, as a male-specific aggregation pheromone. Similarly, the southern green stink bug, Nezara viridula, a generalist pest worldwide on soybean and other crops, releases sesquiterpene cis-/trans-(Z)-α-bisabolene epoxides as …
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Optimizing nuclear transgene expression and genome editing for high-value compound production in the green microalga Chlamydomonas reinhardtii
… were genetically engineered to express various terpene synthases, however, photosynthetic model organisms like the green alga Chlamydomonas reinhardtii only recently gained interest as sustainable production chassis. This eukaryotic microalga inherits multiple beneficial features for fundamental …
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Biochemical, Molecular and Functional Analysis of Volatile Terpene Formation in Arabidopsis Roots
… root-specific formation and function of volatile terpenes in the model plant Arabidopsis. As one objective, we have characterized the two root-specific terpene synthases, TPS22 and TPS25. Both enzymes catalyze the formation of several volatile sesquiterpenes with (E)-β-farnesene as the major …
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Identification, Characterization, and Functional Analysis of Terpenoid Specialized Metabolism in Switchgrass (Panicum virgatum) and Carrot (Daucus carota)
… I investigated the metabolism and function of terpenes, the largest class of specialized metabolites, in switchgrass and carrot. Switchgrass (Panicum virgatum L.), a perennial C4 grass of the Tallgrass Prairie, represents an important species in natural and anthropogenic grasslands of North …
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Implementation of genetic and untargeted metabolomics to study the role of the terpene synthase vir4 from Trichoderma virens in plant-microbe interactions : A thesis submitted in partial fulfilment of the requirements for the Degree of Doctor of Philosophy at Lincoln University
… compounds (VOCs), mostly comprising volatile terpenes. Terpenes are abundantly produced natural products with several biological properties. However, little is known about the role of T. virens volatile terpenes as signalling mediators of the inter-colony communication and modulators of the …