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Showing 1 to 9 of 9 for “"terpene biosynthesis"”.
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Structure and function of the terpene biosynthesis enzyme, IspH
… reductase, is an essential enzyme in isoprenoid biosynthesis and an important drug/herbicide target. The main research in this work investigated the structures and functions of IspHs from various organisms. Using a sequence similarity network we found that some IspHs form ""Rosetta-stone"" fusion …
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Stereochemistry, isotope effects, and inhibition of terpene biosynthesis: I. Stereospecificity and mechanism of monoterpene cyclases. II. Inhibition by heteroatom analogs of carbocation intermediates
Stereospecificity and mechanism of monoterpene cyclases have been investigated by use of deuterium and tritium labeled substrates. The stereochemistry of the terminating deprotonation in limonene biosynthesis was elucidated by radiochemical degradation of ($\sp3$H) carvoximes. Limonene cyclases …
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Identification and Functional Characterization of Sesquiterpene Pheromone Biosynthetic Genes in Stink Bugs (Pentatomidae)
… provide evidence that Pentatomidae produce sesquiterpene aggregation pheromones de novo and discuss the evolution of terpene biosynthesis in stink bugs. According to transcriptome analyses, the investigated stink bug species express at least two isoprenyl diphosphate synthases (IDSs), one of which …
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Synthesis and kinetic studies of tricyclic phosphates and phosphonates: Effect of phosphorus-oxide stereochemistry on allylic rearrangements
"The role of allylic pyrophosphates in terpene biosynthesis is thought to involve S$\sb{\rm N}$1-type ionization leading to an ion-pair. In this work, kinetic studies are reported on tricyclic phosphates and phosphonates which were prepared from 11 and 12 step syntheses. First order rate constants …
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Organometallic Chemistry in Fe–S Clusters
… (SAM) enzymes and enzymes involved in terpene biosynthesis. Due to the transient nature of these intermediates, full characterization of the geometric and electronic structures of enzymatic [Fe₄S₄]–alkyl species has not been possible. To address these challenges, we have synthesized a …
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Cell-type specificity and herbivore-induced responses of primary and terpene secondary metabolism in Arabidopsis roots
… this work is focused on the cell-type-specific biosynthesis of volatile terpenes in Arabidopsis roots. Terpenes are the most abundant specialized metabolites in plants and play an important role in plant defense against pathogens or herbivores. Terpene biosynthetic enzyme activities are often …
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A molecular analysis of the population structure, mating system and demography of Eucalyptus
… compounds implicated in plant defence, notably terpenes. In Chapter 1, I explored the genetic structure in Eucalyptus globulus to understand how processes such as gene flow and genetic drift have shaped the genetic distribution of the species. Using microsatellite-derived genotypes of …
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A molecular analysis of the population structure, mating system and demography of Eucalyptus
… compounds implicated in plant defence, notably terpenes. In Chapter 1, I explored the genetic structure in Eucalyptus globulus to understand how processes such as gene flow and genetic drift have shaped the genetic distribution of the species. Using microsatellite-derived genotypes of …
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Mechanisms of bacterial polyprenyl transferases and multi-target drug discovery for tuberculosis
… that are involved in bacterial cell wall biosynthesis, biofilm formation, virulence formation and natural product formation. Structurally, bacterial polyprenyl transferases can be categorized into eight groups: αcyclase, α, αβ, αβγ, βγ, ε, ζ and TIM barrel fold proteins. Six bacterial …