Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"ternary complex formation"”.
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Development of Protein Degraders Inspired by Chemical Modifications
… E3 ligase-recruiting handle and that tighter ternary complex formation is favored. Mechanistic elucidation via inhibitor screening confirmed that the Dha-based degrader operates through the ubiquitin-proteasome system by recruiting a Cullin-RING E3 ligase. Lastly, transferability studies …
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STRATEGIES TO TARGET HUMAN D-ASPARTATE OXIDASE AND MODULATE ENDOGENOUS D-ASPARTATE LEVELS IN SCHIZOPHRENIA
… with DASPO and E3 ligases, and for the formation of ternary complexes necessary for DASPO proteasomal degradation. Among them, PROTAC 1 showed ternary complex formation with a KD = 1.6 μM and induced hDASPO degradation in a neuroblastoma cell line after 48 hours of treatment. Ternary …
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Defining the mechanisms of microbial sensing among members of the toll-like receptor 2 sub-family
… bind TLR1 and TLR2 resulting in a stable ternary complex that drives intracellular signaling. However, the order of complex formation upon recognition of microbial components is poorly understood. The primary objectives of this dissertation are to define the sequence of events by which …
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Surface Tethered PAMAM Dendrimers On Controlled Pore Glass As Color Release Sensors For Phosphates
… during the IDAs.</p> <p>Indicator-Metal-Ligand ternary complex formation constants were also determined as a reference to the surface works using two colorimetric dyes, bromopyrogallol red (BPR) and pyrocatechol violet (PV). Three metal ions tested were Cu<sup>2+</sup>, Ni<sup>2+</sup>, and …
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Designed bifunctional proteins for induced degradation of androgen receptor in prostate cancer
… solubility and loop length was considerably more complex. Three different approaches were explored in the design of heterobifunctional AR degraders, each targeting one of the three AR domains. In the first approach, we aimed to bind the AR ligand-binding domain by grafting peptides derived from AR …