Global ETD Search
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Showing 1 to 4 of 4 for “"terminal erythroid differentiation"”.
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Application of in vitro erythropoiesis from bone marrow derived progenitors to detect and study genotoxicity
… agents induces physiological MN-formation in erythroid populations derived in vitro. The potential for increased efficiency in this in vitro model depends on the ability to stimulate terminal erythroid differentiation at an optimal level from adult BM.
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Mechanisms of Erythroid Proliferation and Differentiation: Analysis of the Role of Erythropoietin Receptor in the Friend Virus Model
<p>Terminal erythroid differentiation is a precisely regulated process, in which mature red blood cells are generated from late erythroid progenitor cells. Regulation of cellular proliferation, survival and differentiation determines the fate of those cells. Extracellular signaling molecule, …
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Generation and Characterization of a Knock-In Allele of EKLF: Probing the in vivo Role of the Chromatin Remodeling Domain in Definitive Hematopoietic Cells
… zinc finger-encoding transacting factor EKLF, or erythroid Krüppel-like factor, binds key regulatory elements of many erythroid-specific genes, and is essential for definitive erythropoiesis. Mice lacking this factor die of anemia by E15.5 of gestation, failing to activate β-globin gene …
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Stage-Specific Multiomic Analysis of Human Erythroid Differentiation
… Understanding the mechanisms of Epo-dependent erythroid differentiation is critical for identifying targets for the future development of therapeutics that increase RBC production and improve patient outcomes. Background: Erythropoiesis, the process of RBC (erythrocyte) production from …