Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"terminal differentiation"”.
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Blimp-1 Regulates Terminal Differentiation of T Cells
The transcriptional repressor-Blimp-1 terminates differentiation of B lymphocytes as well as myeloid cells. Our data show that Blimp-1 is highly expressed in freshly isolated murine primary T lymphocytes, particularly its minor splice variant. Ectopic expression of Blimp-1 by retroviral …
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Regulation of B lymphocyte terminal differentiation and death by the transcription factor Blimp-1
… als Transkriptionsfaktoren unverzichtbar für die terminale Differenzierung von B-Lymphozyten zu Immunglobulin (Ig)-sezernierenden Plasmazellen. Ebenso stellen die unfolded protein response (UPR) und das Spleißen von XBP-1, beides ausgelöst durch erhöhte Ig-Produktion, entscheidende Schritte auf …
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Potential roles for transforming growth factor-B during terminal differentiation of ocular lens cells /
During terminal differentiation, lens fiber cells permanently withdraw from the cell cycle, migrate posteriorly along the lens capsule, become greatly elongated and eliminate all cellular organelles. Lens fiber differentiation may be controlled by various factors within the ocular environment. The …
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Developmental Dynamics of 5-Hydroxymethylcytosine and its Role in the Terminal Differentiation of Neurons
… regulation of migration, synapse formation and terminal differentiation. Although 5-hydroxymethylcytosine (5hmC), the oxidized form of 5-methylcytosine, accumulates to high levels in neuronal lineages and refines the genomic binding of MeCP2, the functional consequences of 5hmC deposition in …
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The C. elegans heterochronic pathway controls the timing of NAB/EGR-mediated terminal differentiation and the onset of adulthood
… on their expression patterns and roles in the terminal differentiation of tissues outside of the hypoderm. We use a mab-10 translational reporter to show that MAB-10 accumulates precociously in precocious heterochronic mutants and that mab-10 transcription does not require lin-29, suggesting …
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Plasma membrane-derived vesicles: their role in the terminal differentiation of monocytes and in inhibiting the phagocytosis of apoptotic cells
… We have examined the role of PMVs, in the differentiation of HL-60 promonocytes. The myeloid differentiating agents ATRA, PMA and histamine, which inhibit promonocyte proliferation, induced an intracellular Ca2 +-mediated PMV (as opposed to exosome) release from HL-60 promonocytes. These …
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Effects of Neonatal Dexamethasone on the Maturation and Endowment of Cardiomyocytes
… birth myocytes exit the cell cycle and become terminally differentiated. It is therefore crucial that sufficient proliferation occurs before terminal differentiation takes place to ensure adequate cardiomyocyte endowment in the mature heart. The purpose of this study is to test the hypothesis …
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Cell lineage choice during differentiation of trophoblast stem cells (tsc) is dependent on oxygen levels, and mediated by stress enzyme pathways and mitochondrial function
… and 20% oxygen.</p> <p>Next, we interrogate TSC differentiation at different oxygen levels. Our data show that only TSC differentiated under 20% oxygen can complete the terminal differentiation while differentiation under low oxygen exhibits reduced terminal differentiation by real-time PCR. Even …
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Perinatal Hypoxia Exposure on the Developing Heart: The Role of Endothelin-1
… and thus cardiac function, is the period of terminal differentiation. This involves the maturation of cardiomyocytes and is essential to heart development, however acceleration of this process may alter cardiomyocyte endowment. Hypoxia/anoxia is a major perinatal stressor that often afflicts …
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Genetic screens of RNA binding proteins identify a role for N6-methyladenosine in promoting B cell differentiation
… CD8 T cell activation, and B cell terminal differentiation. These identified over a dozen potential avenues of future investigation into the roles of RBPs in lymphocytes. I chose to further investigate the role of the RNA modification N6-methyladenosine (m6A) in B cells. This work …
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Mechanisms of Erythroid Proliferation and Differentiation: Analysis of the Role of Erythropoietin Receptor in the Friend Virus Model
<p>Terminal erythroid differentiation is a precisely regulated process, in which mature red blood cells are generated from late erythroid progenitor cells. Regulation of cellular proliferation, survival and differentiation determines the fate of those cells. Extracellular signaling molecule, …
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The Role of TCR Engagement Strength in Antitumor CD8 T Cell Exhaustion
… regulates the preservation of Tpex and their terminal differentiation during tumor progression. To investigate this, I established multiple murine tumor models, including Lewis lung carcinoma, which elicit an optimal or attenuated TCR signal in CD8 T cells. Longitu- dinal phenotyping and …
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H36-alpha7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis
… glycoprotein that is expressed during the differentiation of skeletal muscle. H36 cDNA clones were isolated from a lambda UniZapXR rat myotube cDNA library and sequenced. The deduced amino acid sequence demonstrates that H36 is a novel integrin alpha chain that shares extensive homology …
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Investigating the cytoplasmic role of E2F4 in multiciliogenesis
… cellular processes including proliferation and terminal differentiation. Transgenic mouse models have established that E2F4 is necessary for multiciliogenesis in the airway epithelia. Here we show that E2F4 plays two distinct roles in multiciliogenesis. In early stages, it functions in the …
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Developmental regulation of the alpha(7) integrin chain during myogenesis
… of $\alpha$7 transcripts increased upon myogenic differentiation, differential splicing of transcripts is also observed at that time. This differential splicing of $\alpha$7 transcripts results in three different mRNAs which encode $\alpha$7 chains with three different cytoplasmic domains. The …
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Characterization of CD8 T cell responses in Mycobacterium Tuberculosis infection
… assess turnover, susceptibility to apoptosis and terminal differentiation/senescence in CD8 T cells from TB and LTBI donors. Bcl-2, Ki67,CD95, CD57, CD127 and IFNγ were thus measured in each group.
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Transcriptional Regulation of Adult Neurogenesis by NRSF/REST and NeuroD1
… stem cell pool and for proper pacing of neuronal differentiation. NeuroD1, a bHLH transcription factor, is necessary for the terminal differentiation, maturation, and survival of newborn neurons. In addition, both factors are necessary for the neurogenic response to both physiological and …
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Transcriptional Regulation of Neuronal Differentiation in the Drosophila Central Nervous System
… of transcription factors directly control the terminal differentiation of neurons via the regulation of different genes, such as neurotransmitters. My thesis work has focused on the identification and characterization of new members of the combinatorial code of transcription factor and on …
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TCF4-mediated Transcriptional Regulation of Krüppel-like Factor 4 Gene
… 하는 역할에 필수적이다. 또한 KLF4은 다양한 조직에서 발연하고 세포증식, terminal differentiation, 세포사멸과 같은 많은 생리적 과정에서 중요한 역할을 수행한다. 그 기능으로는 일반적 항상성, 세포 분화, 그리고 암 형성에 밀접하게 관여한다. 이런 조직 특이성에 대한 전사적 결정을 드러내도록 노력하기 위해 우리는 transcription factor 4 (TCF4) 단백질이 binding 하는 것으로 알려진 두 개의 AT-/TA-CAAAG conserved motif를 확인하였다. …
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Role of JAK3 in Myogenic Differentiation
Skeletal muscle differentiation is regulated by transcription factors, including members of the myogenic regulatory factors (MRFs) family and many signaling pathways. The JAK1 and JAK2 pathways are known to each have different effects on myoblast proliferation and differentiation; however, the role …
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