Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"teratogenicity"”.
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Toxicity and Teratogenicity of Conium Maculatum in Swine and Hamsters
Feeding trials presented in this research thesis positively show that poison hemlock seed and plant material are both toxic and teratogenic in swine.
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A study of the teratogenicity of diphenylhydantoin and phenobarbitone in the experimental mouse
… system, to investigate possible mechanisms of teratogenicity and to examine whether the methods used in this study, may form a basis for developing systems of more extensive drug teratogenicity screening.
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Potentiating effects of caffeine on the teratogenicity of acetazolamide in two strains of mice
… to determine the effect of caffeine on the teratogenicity of acetazolamide in susceptible and resistant strains of inbred mice. The highly susceptible C57BL/6J and more resistant SWV strain were used. Pregnant C57BL/6J and SWV mice were treated with caffeine, low or high dose acetazolamide, …
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Placental epigenetic modifications and development in valproic acid-induced teratogenesis
… serve as an important mechanism of VPA-induced teratogenicity. The purpose of this thesis was to investigate the effect of VPA on placental epigenetics, as well as placental growth and development, in the CD1 mouse model. We exposed pregnant mice to 600 mg/kg of VPA or saline on GD13 and …
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Development of a new screening assay to identify proteratogenic compounds using Zebrafish Danio rerio embryo combined with an exogenous mammalian metabolic activation system (mDarT)
… chemicals is generally performed using in vivo teratogenicity assays e.g., in rats or rabbits. Following the 3R principles, the development of alternative methods is encouraged to reduce the number of animal tests. From this perspective, we have developed an in vitro assay (mDarT) using the …
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Pharmacovigilance in Post-Marketing: Risk Assessment and Reporting Standards
… for patients, there is a known serious risk of teratogenicity for females of reproductive potential. The risk of teratogenicity is so prominent that the Food and Drug Administration (FDA) required Letairis be placed on the risk evaluation and mitigation strategy program (REMS) to continually …
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Dysregulated Apoptosis in Teratogen-Induced Neural Tube Defects in Mice
… apoptosis, suggesting involvement in VA teratogenicity, was observed along the neural tube in both normal and abnormal embryos from VA-exposed dams. Increased apoptosis in normal VA-exposed embryos suggests that VA may alter other cellular processes such as cell proliferation and …
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Entwicklung und Erprobung eines Teratogenitäts-Screening Testes mit Embryonen des Zebrabärblings Danio rerio
… läßt. Dazu wurde DarT (?Danio rerio Teratogenicity Assay?) als Teratogenitäts-Screening Test entwickelt. Es können anhand von toxikologischen Endpunkten sowohl die letalen als auch die subletalen Wirkungen von Substanzen bestimmt werden. Darüber hinaus werden anhand von teratogenen …
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Development and characterization of novel toxoplasma gondii inhibitors
… currently available are limited by toxicity and teratogenicity. This necessitates the development of novel drug compounds. Tryptanthrin and its analogue, 8-bromotryptanthrin, have shown promise in the treatment of <italic>Toxoplasma gondii in vitro</italic>. New tryptanthrin derivatives were …
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Chronic prenatal ethanol exposure produces neurobehavioural and metabolic dysfunction in guinea pig offspring
… function in offspring. The mechanism of ethanol teratogenicity is multi-faceted and could involve alterations in insulin and insulin-like growth factor (IGF) signaling pathways. These pathways are not only important for metabolism, but are also involved in CNS neuronal survival and plasticity, …
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Investigation of Teratogenic Concerns In The Covid-19 Era
… and pregnancy complications. Research on the teratogenicity of COVID-19 is still ongoing, but overall neither COVID-19 infection nor vaccination appear to increase the risk of birth defects. Numerous studies have investigated healthcare providers’ opinions on whether and when pregnant people …
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Moderate Ethanol Consumption by the Pregnant Guinea Pig Increases Ethanol Preference in Offspring
Ethanol teratogenicity involving the developing brain is the leading preventable cause of mental deficiency in the Western world. Chronic prenatal ethanol exposure (CPEE) may be a risk factor for ethanol abuse and altered responsiveness to nicotine in postnatal life. Previous studies in our …
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The Effect of Trypan Blue on the Growth Rate of the Chick Embryo During Development
… growth does not appear to be a mechanism for the teratogenicity of trypan blue. Recommendations. The development around the 14th day might be worth examining further to see if there is a triggering in the metabolic processes whioh cause the weights to be consistently lower the last seven days of …
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IRON OVERLOAD AND BIRTH DEFECTS
… placental and foetal mechanisms in iron-dextran teratogenicity is discussed.
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Ultrasonic absorption in soft and hard fetal tissues
… absorbed from the acoustic wave. Because the teratogenicity of hyperthermia has been well-established and concerns of more subtle effects of elevated fetal temperature exist, there is currently a concerted effort to provide manufacturers of medical diagnostic ultrasound instrumentation and …
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Evaluating Treatment of Antiphospholipid Syndrome during Pregnancy with Knowledge Synthesis Methods
… during the first trimester due to established teratogenicity. Finally, a systematic review was conducted to assess the pregnancy associated pharmacokinetic changes of three groups of medications used for APS (1. low-dose aspirin; 2. unfractionated heparin and low-molecular weight heparin; and …
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Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development
… One proposed mechanism of VPA-initiated teratogenicity is the inhibition of histone deacetylase (HDAC), which is involved in the regulation of transcription factors associated with cardiogenesis. Myocyte enhancing factor 2C (Mef2c), a transcription factor involved in development of …
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Physician Perceptions of Risk Regarding Mood Disorders and Pharmacological Management During Pregnancy: What Is Current Practice?
… knowledge gap among obstetricians regarding the teratogenicity of common psychotropic medications utilized to manage a patient population they frequently encounter. Further, obstetricians have vastly different risk perceptions of these medications, resulting in various management approaches and …
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Drinking water disinfection by-products: toxicological impacts and biological mechanisms induced by individual compounds or as complex mixtures
… cytotoxicity, genotoxicity, mutagenicity and teratogenicity published in the literature. A novel single well microplate-based ATP-protein assay was developed and with this assay, monoHAAs showed the greatest reduction in ATP levels while diHAAs showed a moderate reduction with higher …
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