Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"teratogenesis"”.
-
Placental epigenetic modifications and development in valproic acid-induced teratogenesis
Valproic acid (VPA) is an anti-epileptic and a teratogen. In utero exposure to VPA is associated with congenital malformations and neurodevelopment disorders. VPA exerts its teratogenic effects through epigenetic dysregulation, which interferes with tissue development and function. Evidence …
-
Thalidomide-induced teratogenesis in gray short-tailed opossums (Monodelphis domestica)
… as a novel mammalian to study thalidomide teratogenesis. In M. domestica we have successfully recreated most morphological defects found in human thalidomide victims. Through RNA sequencing, we have also identified two gene that may play a significant role in the mechanism of thalidomide …
-
Valproic Acid-Induced Teratogenesis in Japanese Rice Fish (Oryzias Latipes) Embryogenesis
… as an animal model to study valproate-induced teratogenesis during the period of embryogenesis. Fertilized embryos of Japanese rice fish at three developmental stages (group A: 0–2 dpf; group B: 1–3 dpf; group C: 4–6 dpf) were exposed to VPA (0–80 mM) for 48 hrs. The amounts of VPA to cause 50% …
-
A novel low-density lipoprotein receptor-related protein protects against environmental teratogens
… designated it lrp13b. I have found that ethanol teratogenesis in lrp13b mutants is made more severe by increased developmental temperature. Mutants in lrp13b experienced increased apoptosis and fail to properly differentiate facial cartilages when exposed to environmental teratogens. My data …
-
The effect of a zinc deficiency and alcohol intake during gestation in the rat
… and 2, respectively, in any of the other groups. Teratogenesis caused by a Zn deficiency was increased with alcohol consumption.
-
G-Protein-Coupled Estrogen Receptor-1 (GPER): A Potential Target For Xenoestrogens During Vertebrate Embryogenesis.
… (3) co-exposure with G-15 blocked G-1-induced teratogenesis, suggesting that G-1 toxicity is mediated via aberrant GPER activation. Based on these data, we hypothesized that the developing cardiovascular system was the primary target organ for G-1-induced toxicity. Using quantitative in vivo …
-
Immunoteratological Studies of Diabetic Embryopathy Using Gene Expression Analysis
… result in protection against diabetes-related teratogenesis, but only if given prior to onset of hyperglycemia. Such immune stimulation in mice may act through systemic immune organs, i.e. spleen, over-riding adverse effects of diabetes on development.
-
Later Life Consequences of Subteratogenic Exposure to a Complex PAH Mixture in the Atlantic Killifish (Fundulus heteroclitus)
… embryonic exposure to PAHs results in cardiac teratogenesis in fish, and early life exposure to certain individual PAHs and PAH mixtures cause heart alterations with decreased swimming capacity in adult fish. Consequently, the heart and cardiorespiratory system are thought to be targets of PAH …
-
Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma
Each year, 7.9 million babies are born with birth defects. Seventy percent of those could be prevented, ameliorated, or repaired; yet 3.2 million children still die by the age of three (March of Dimes Global Report 2006). We have found that non-specific maternal immune stimulation with the cytokine …
-
Dysregulated Apoptosis in Teratogen-Induced Neural Tube Defects in Mice
Dysregulation of apoptosis during development is a possible mechanism for teratogen-induced birth defects. Neural tube defects (NTDs) are the second most common fetal malformations. Non-specific stimulation of maternal immune system prevents birth defects. This study investigated the role of …
-
The Effects of Propofol, Sodium Pentobarbital, and Ketamine Hydrochloride on <i>In Vitro</i> Mouse Embryonic Development
<p>Every year more than 75,000 pregnant women are exposed to teratogenic medications or general anesthesia during non-obstetric surgery in the US,1-4 and embryonic effects of general anesthesia are of particular interest in laboratory research and veterinary medicine. The mouse system is used to …
-
ΕΠΙΔΡΑΣΗ ΚΑΡΚΙΝΟΓΟΝΩΝ ΟΥΣΙΩΝ ΣΤΗΝ ΑΝΑΓΕΝΝΗΣΗ ΤΩΝ ΑΚΡΩΝ ΤΟΥ ΟΥΡΟΔΕΛΟΥΣ ΑΜΦΙΒΙΟΥ TRITURUS CRISTATUS
THE MAIN AIM OF THIS RESEARCH IS THE STUDY OF THE EFFECTS OF CHEMICAL CARCINOGENS ON INFACT AND REGENERATING LIMBS OF ADULT TRITURUS CRISTATUS (AMPHIBIA URODELA). CARCINOGENIC SUBSTANCES WERE ADMINISTERED TO INTACT OR REGENERATING LIMBS,THE LAST BEING IN THREE REGENERATIVE STAGES CHOSEN AS FOLLOWS: …