Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"teratogen"”.
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Dysregulated Apoptosis in Teratogen-Induced Neural Tube Defects in Mice
… during development is a possible mechanism for teratogen-induced birth defects. Neural tube defects (NTDs) are the second most common fetal malformations. Non-specific stimulation of maternal immune system prevents birth defects. This study investigated the role of dysregulated apoptosis in …
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Longitudinal Effects of Prenatal Teratogen Exposure on Executive Function and Academic Outcomes
… to adulthood. For children prenatally exposed to teratogenic substances (i.e., certain prescription medications, maternal infections or conditions, alcohol, tobacco, etc.), higher-order cognitive skills may be compromised, resulting in an increased risk of delayed developmental functioning, …
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Cell Death as a Morphogenetic Basis for Abnormal Development in Mutant-Bearing and Teratogen-Treated Embryos.
Cell death is known to be a widespread and essential event during the normal development of many tissues and organs (Glucksmann, 1965). Whole organs may degenerate during normal organogenesis. For example, massive necrosis is necessary for the proper formation of the excretory and urogenital duct …
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The Interaction of a Mutant Gene, Paddlefoot (Pf), and a Teratogen, 6-Azauridine, on Limb Development in Two Inbred Strains of Mice.
… mutant genes with either chemical or physical teratogens. Results of such studies have been reported in chickens, Drosophila and mammals (Landauer, '48, '60, '65; Goldschmidt and Piternick, '57; Barber, '59; Beck, '63, '64; Dagg, '66, '67, '72; Forsthoefel, '72, '75; Johnson, '70; Hamburgh et …
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Physician Perceptions of Risk Regarding Mood Disorders and Pharmacological Management During Pregnancy: What Is Current Practice?
… many of these medications are known human teratogens. Because pregnant women with mood disorders face a high risk of relapse if unmanaged, the obstetrician faces a unique challenge in providing the best care to both mother and baby.</p> <p> It has been suggested that many obstetricians …
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An electrophoretic study of fetal mouse brain proteins after in vivo exposure to phenytoin and disulfiram
… to determine the effects of various teratogens on whole embryos. No protein changes were found and that line of research was not continued. In this study two-dimensional gel electrophoresis is extensively used, in the belief that the usefulness of this technique to experimental …
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Valproic Acid Disrupts Hematopoiesis in Xenopus Laevis Through the Inhibition of Histone Deacetylase 3.
… associated with exposure to VPA, a significant teratogen in humans, arise through inhibition of class I HDACs.
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A novel low-density lipoprotein receptor-related protein protects against environmental teratogens
… exposure interacts with another well-established teratogen: prenatal hyperthermia. Additionally, each of these teratogens interacts with the genetics of the exposed individual. A foreword genetic screen identified a mutation in an uncharacterized locus that sensitizes developing zebrafish to both …
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Perspectives On Ethanol Toxicity In Medaka Embryogenesis And Possible Protection By Asian Ginseng (Panax Ginseng): Histological And Biochemical Analysis
Alcohol is recognized as a classic teratogen capable of inducing a wide range of developmental abnormalities. Alcohol consumption during pregnancy may produce permanent brain damage in the fetus and is associated with the development of a life-long behavioral, social, and cognitive disorder now …
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THE EFFECTS OF TRICHLOROETHYLENE ON HEART DEVELOPMENT
… data suggest cardio-specificity of TCE as a teratogen and may reflect a requirement for normal calcium regulation of contractile function during organ development.
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Zebrafish cardiovascular cDNA microarrays : expression profiling and gene discovery in embryos exposed to 2,3,7,8-Tetrachlorodibenzo-ρ-dioxin
… (TCDD) is a potent teratogen that impacts the developing cardiovascular system. Hallmarks of embryonic exposure include cardiac malformation, impaired circulation, loss of erythrocytes, pericardial and yolk sac edema, and early life stage mortality. However, the …
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Placental epigenetic modifications and development in valproic acid-induced teratogenesis
Valproic acid (VPA) is an anti-epileptic and a teratogen. In utero exposure to VPA is associated with congenital malformations and neurodevelopment disorders. VPA exerts its teratogenic effects through epigenetic dysregulation, which interferes with tissue development and function. Evidence …
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Relation between reported maternal caffeine consumption during pregnancy and neonatal state and heart rate
… may indeed function as a physical and behavioral teratogen. In addition to consistent findings of adverse physical outcomes such as prematurity and fetal growth retardation in both animals and humans, adverse effects of maternal caffeine consumption during pregnancy on behavioral development in …
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The identification, purification and characterization of the fetal rat liver glutathione S-transferase isoenzyme YcYfetus
… The in vitro effect of the GSH S-T substrate and teratogen, acrolein, on this fetal isoenzyme was investigated and compared with acrolein's effect on some of the adult rat liver GSH S-T isoenzymes in the standard 1-chloro-2,4-dinitrobenzene assay. Surprisingly, acrolein was identified as a …
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Craniosynostosis in a South Africa population
… The prevalence of phenotypic findings, teratogen exposure, birth complications, congenital malformations, surgical interventions and results of genetic testing in this cohort is described. Descriptive statistical analysis was used. Results: A total of 47 children with craniosynostosis …
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Valproic Acid-Induced Teratogenesis in Japanese Rice Fish (Oryzias Latipes) Embryogenesis
… drugs. Valproic acid is designated as a human teratogen, which induces major congenital anomalies, facial dysmorphic features, and autistic-like behaviors, which affect verbal, cognitive, communicative, and social abilities of affected children. We are developing the Japanese rice fish (Oryzias …
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A study of the pathogenesis of fetal damage caused by ethanol in the experimental mouse
… I would suggest that acetaldehyde is a true teratogen, and the abnormalities produced in the chronic ethanol in vivo study were probably largely due to the action of acetaldehyde.
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Neurotrophic Theory of Accelerated Temporal Cortex Maturation in the Valproic Acid Rat Model of Autism
… it is altered with exposure to the autism-linked teratogen valproic acid (VPA). My overarching hypothesis was that the slow maturation of TeA neurons during the first three weeks of postnatal development is a result of low local production and/or secretion of brain derived neurotrophic factor …
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A study of acetylcholinesterase and cholinesterase in the fetal mouse brain and a study of the effects of three teratogens, vitamin A, cyclophosphamide and sodium valproate on the fetal mouse central nervous system
… markers for the evaluation and prediction of the teratogenic potential of drugs, and (ii) to try and throw more light on pathogenic mechanisms of drug injury with particular reference to the developing fetal central nervous system. Acetylcholinesterase activity in brain homogenates was determined …
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