Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"tensin"”.
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Metabolic regulation in Phosphatase and tensin homologue (PTEN) null T cell lymphoma/leukaemia cells
Deletion of PTEN selectively in T cell progenitors in the thymus results in the rapid development of aggressive T cell lymphomas in a mouse model for T-ALL. We showed that PTEN-/- T cell lymphoma/leukaemia cells were metabolically active as they readily took up key nutrients. Thus, they had high …
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Diverse functions for intern associated proteins in Drosophila adult muscle
… muscle detachment. However, the IAPs FAK, RSU1, tensin, vinculin and zyxin are not required for viability or embryonic muscle attachment. Furthermore, FAK, RSU1, tensin and vinculin have been observed to localise to muscle attachment sites in Drosophila, indicating that they have some function in …
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The molecular mechanisms of pseudogene-mediated PTEN expression.
The phosphatase and tensin homolog, PTEN, is a protein that negatively regulates the PI3K-Akt pathway through its phosphatase activity. PTEN is a tumour suppressor gene and mutations to the PTEN gene are often a precursor to the development of cancerous cells, common in many different types of …
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The Effects of PTEN Deletion on Cell Size and Plasticity in the Hippocampus
<p>The tumor suppressor phosphatase and tensin homolog (PTEN) is the central negative regulator of the phosphatidylinositol 3-kinase (PI3K) -signaling pathway, which mediates diverse processes in various tissues. In the nervous system, the PI3K pathway modulates proliferation, migration, cellular …
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PTEN-5-HT2CR Complex: An Ideal Target for Developing Treatment to Restore the Functioning of 5-HT2CR; An Attempt to Minimize the Development of Antimicrobial Resistance
… between the 5-HT2CR and protein phosphatase and tensin homologue (PTEN) limited the activity of the receptor. The disruption of the interaction has been demonstrated to restore the activity of 5-HT2CR. A key fragment (3L4F-F1) of 5-HT2CR can disrupt the interaction between 5-HT2CR and PTEN. To …
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Matriptase/pdgf D/beta-Pdgfr Signaling Axis In Human Prostate Cancer: The Role Of Pten In The Regulation Of Pdgf D Expression
… relevant prostate-specific PTEN (phosphatase and tensin homolog) knockout mouse model, we found an increase in PDGF D expression and ?-PDGFR phosphorylation upon loss of PTEN. Upon inhibition of the PI3K pathway, PDGF D/ ?-PDGFR induction was abolished in PTEN-/- cells. Among Akt isoforms, …
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Effects of Regional Deletion of Rab3A-interacting Molecule and PTEN on Brain Function
… Molecule (RIM1) and the phosphatase and tensin homologue on chromosome 10 (PTEN). The cre-lox system was used to eliminate RIM1 from the hippocampal dentate gyrus and area CA3, while adeno-associated virus expressing PTEN-directed interference RNA was injected into the basolateral …
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Part I: Disruption of PTEN-5-HT2CR Coupling: A Potential Treatment for Restoration of 5-HT2CR Function / Part II: Rapid Total Synthesis of Cyclodepsipeptide MA026
… of the 5-HT2CR with protein phosphatase and tensin homologue (PTEN) has been demonstrated to limit the activity of that receptor to its native agonist. Disruption of this protein-protein interaction has been demonstrated to restore activity of 5-HT2CR. Work to develop physiologically-stable …
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PTEN-LONG, a translational variant of the canonical tumor suppressor PTEN
Phosphatase and Tensin Homologue on chromosome Ten (PTEN) is a tumor suppressor and an antagonist of the phosphotidylinositol-3 kinase (PI3K) pathway. We identified a 576-amino acid translational variant of PTEN, termed PTEN-Long, that arises from an alternative translation start site 519 …
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Be Eaten to Stay Healthy: Elucidating the Mechanisms of Mitochondrial Quality Control by Mitophagy
… disease related proteins phosphatase and tensin homolog-induced putative kinase 1 (PINK1) and Parkin have been identified as important regulators of mitophagy in mammalian cells, directly linking mitophagy to neurodegeneration. The role of these two proteins in this mitophagy is further …
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Tyrosine phosphorylation and cytoskeletal tension regulate the release of fibroblast adhesions
… tyrosine phosphoproteins are FAK, integrin, tensin, paxillin or other phosphoproteins implicated in focal adhesion assembly. The second mechanism is cell contraction. High ATP concentrations, or lower ATP concentrations in the presence of okadaic acid induce cell contraction. Inhibiting the …
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Protein-Protein Interactions with Serotonin G Protein Coupled Receptors: Novel Targets for Neurotherapeutics Drug Discovery
… interaction with the protein phosphatase and tensin (PTEN) via peptide-based PPI disrupters enhance 5-HT2CR-mediating signaling in vitro and potentiates selective 5-HT2CR agonists in behavioral rodent models. On the other hand, antagonism of the 5-HT2AR is postulated to be a critical component …
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Design and Development of a Novel Immunological Method to Quantify target-specific cysteine redox state in a microplate
… Tyr phosphatase 2 (SHP-2), phosphatase<br/>and tensin homolog (PTEN), cγ subunit of protein phosphatase 2B (PP2B) and<br/>the bulk thiol pool. These findings provide further insight into the redox regulation<br/>of endotoxin signalling and showcase the various advantages of RedoxiFluor.
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Role of Toll-Like Receptor 4 in Pathophysiology of Hypertension
… hyperten-sive and inflammatory responses of Angiotensin II (Ang II; an effector molecule of renin angio-tensin system) in mice lacking the gene for the TLR4. Next, we confirmed the role of TLR4 in the PVN in pathophysiology of hypertension by investigating the effects of PVN-specific …
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Pten Function in Postnatal Brain Development and Tumorigenesis
<p><em>PTEN</em> (Phosphatase and Tensin homolog deleted on chromosome 10) is a tumor suppressor gene that is commonly mutated in multiple types of human cancers including endometrial, prostate, breast cancers and glioblastoma multiforme (GBM). PTEN functions as a phospholipid phosphatase …
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microRNA-21 as a Pro-Fibrotic Mediator in Right Ventricular Failure
… LV) and is known to target phosphatase and tensin homolog (PTEN), a negative regulator of fibroblast proliferation. PTEN also inhibits the phosphorylation/activation of Akt, a positive regulator of fibroblast proliferation. Myocardial PTEN was indeed selectively downregulated in HF-RV and …
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Studies of the PTEN tumour suppressor in endometrial cancer.
… mutations in the PTEN gene (Phosphatase and Tensin Homologue Deleted on Chromosome Ten) have been found in many types of cancer, but most frequently in cancer of the endometrium.The PTEN gene encodes a D3 lipid phosphatase of the second messenger phosphatidylinositol 3,4,5-trisphosphate …
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The Role of IGF-1 and Notch Signaling in Thoracic Malignancies.
… its negative regulation of phosphatase and tensin homolog (PTEN) and positive regulation of the IGF-1 receptor (IGF-1R) expression causes activation of the pro-survival IGF-1/Akt-1 signaling pathway. These results provide new insight into the role of Notch in MM and lung cancer, and strongly …
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The Effect of Manipulation of the Phosphoinositide 3-kinase Pathway on Axon Regeneration in vivo
… by transgenic knockout of phosphatase and tensin homolog (PTEN) promotes survival and regeneration of murine RGC axons in an optic nerve crush (ONC) model. However, translation issues are yet to be addressed. PI3K converts phosphatidylinositol (3,4)-bis-phosphate (PIP2) lipids to …
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Dual regulation of transcription factor Nrf2 by Keap1 and the beta-TrCP/GSK-3 in cancer
… ferulic acid directly decreased phosphatase and tensin homolog (PTEN) activity, thereby preventing formation of the phosphodegron in the Neh6 domain of Nrf2.<br/><br/>With increased Nrf2 levels reported in various cancers including lung cancer, leading to the progression of these cancers, Nrf2 …
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