Global ETD Search
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Showing 1 to 7 of 7 for “"tenase"”.
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FUNCTIONAL STUDIES WITH DIRECT ORAL ANTICOAGULANTS: INVESTIGATION OF THE REGULATION OF KEY BLOOD COAGULATION PROTEASES
… upstream of prothrombinase, the intrinsic tenase is only moderately protected, while there is no protection at the level of the initiator complex, extrinsic tenase. This protection phenomenon possibly reflects steric and allosteric mechanisms that ensure maximal activation of the …
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Microfluidic Approaches to Thrombosis and Hemostasis: Towards a Patient-Specific Test of Antiplatelet Therapeutics and the Assessment of Coagulopathy in Hemophilic and Trauma Patients
… factor to evaluate the role of the intrinsic tenase in conjunction with exogenous rFVIIa when surface-triggered extrinsic pathway is present. Finally, we continued to assess coagulopathic patients by first mimicking resuscitation-driven hemodilution, hyperfibrinolysis, and plasmin-inhibitor …
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Inhibiting platelet scramblase activity
… (PS) which acts as a surface for binding of the tenase (FIXa/VIIIa) and prothrombinase (FXa/Va) complexes that generate a burst of thrombin production responsible for occlusive clot formation. All current anti-platelet drugs are associated with bleeding side effects since they inhibit …
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Targeting phosphatidylserine exposure in pro-coagulant platelets.
… the negatively charged surface. Assembly of the tenase and prothrombinase complexes enhances their activity, increasing thrombin generation. PS is normally confined to the inner leaflet of the plasma membrane by flippase activity, preventing its exposure on the outer surface of unstimulated and …
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Contribution of different types of phospholipids in blood coagulation
… complex might not be as stringent as the tenase complex(the complex of TF and fVIIa, which are responsible for converting fX to fXa). In conclusion, we proposed a new hypothesis for binding of GLA domains of clotting factors to phospholipid membranes and showed a new phospholipid …
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Blood coagulation reactions on nanoscale membrane surfaces
Blood coagulation requires the assembly of several membrane-bound protein complexes composed of regulatory and catalytic subunits. The biomembranes involved in these reactions not only provide a platform for these procoagulant proteins, but can also affect their function. Increased exposure of …