Global ETD Search
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Showing 1 to 8 of 8 for “"template-directed synthesis"”.
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Hydrogen Bond Template-Directed Synthesis of Recognition-Encoded Melamine Oligomers
The directed evolution of biopolymers is based on the mutagenic replication of DNA. However, reliance on DNA limits the application of directed evolution to molecules that can be encoded by DNA, such as proteins. The development of a synthetic oligomer which can mutagenically replicate could unlock …
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Template-Directed Synthesis of One-Dimensional Hybrid Nanostructures from Cylindrical Polymer Brushes
… polymer brushes (CPBs) and their use in template chemistry. Herein, we developed template-directed syntheses of one-dimensional (1D) hybrid nanostructures in which CPBs served as 1D soft templates. So called ‘molecular’ core-shell or core-shell-corona CPBs, as well as CPBs obtained …
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Prebiotic assembly and replication of nucleic acids
… example, polymerization of monomer units of RNA directed by base pairing interactions with an RNA template strand has been achieved in the absence of enzymes through a process called template-directed synthesis. Despite such popularity and over half a century of laboratory experiments, there …
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Automated Synthesis of Duplex-Forming Recognition-Encoded Oligomers
… for such a system. An automated solid-phase synthesis (SPS) route was optimised to yield high-purity REMOs with precise sequence control. Loaded Wang resin was reacted alternatingly with piperazine and dichlorotriazine monomers, appended with phenol donor (D) or phosphine-oxide acceptor (A) …
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Collective Evolution of Biological and Physical Systems
… on the speed, accuracy and energy efficiency of template-directed synthesis processes such as translation, transcription and replication can lead to the spontaneous emergence of genome biases. Selection on translation leads to codon usage bias; selection on transcription or replication leads to …
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s-Triazine-Based Self-Assembling Information Molecules
… sites, which should lead to duplex assembly and template-directed synthesis, i.e. synthetic analogues of DNA. The oligomers are composed of four components: a recognition-based pairing system, backbone, linker and solubility controlling moieties. The oligomers were synthesised using the selective …
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Phenylacetylene oligomers as synthetic information molecules
… of nucleobases. Through duplex formation and template directed synthesis, the information stored in nucleic acids determines their three-dimensional structure and function. Nucleic acids are essential molecules for biological processes and have been used in nanotechnology. Modified nucleic …
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CONTROLLED SYNTHESIS OF TOPOLOGICALLY TEMPLATED CATENANE AND KNOTTY POLYMER
… in obtaining high yields. Chapter 1 reviews template directed synthesis of low molecular weight catenanes and the trefoil knot. In addition, recent advances in synthesis of topologically similar cyclic polymer via end-to-end cyclization of linear analogue or ring-expansion polymerization from …