Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"telomeric overhang"”.
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Structural dynamics of telomeric overhang accessibility
… specialized reverse transcriptase, which can add telomeric repeats to the 3’ end of chromosomes. In normal cells, the telomere is shortened due to the end replication problem and DNA degradation, which sets the cell lifespan. 85% of cancer cells can escape this growth limitation by upregulating …
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Mechanisms That Ensure the Proper Terminal Structure of Mammalian Telomeres
<p>The telomeric single-stranded 3' overhang, a conserved feature at the ends of linear chromosomes, is thought to contribute to the important functions of end protection and telomere length homeostasis. Here, I investigated the mechanism by which the overhang is generated and maintained at …
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The Role of Pot1 in Telomere Protection and Maintenance
<p>POT1 is a single stranded telomeric DNA binding protein implicated in telomere length regulation in human cells. To address the role of POT1 in telomere protection we used RNAi in human cells. We confirmed that POT1 acts as a negative regulator of telomerase and showed that POT1 is required to …
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Structural characterization of G-Quadruplexes within duplex DNA
… target. Despite the plethora of reports on telomeric DNA, relatively few studies have looked into GQs located within genomic regions. Furthermore, most studies focused on several well-characterized sequences such as c-Myc, TERT and BCL2 formed in the context of ssDNA. Although ssDNA may be …