Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"telomere-binding proteins"”.
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Functional Analysis of the Human SMC5/6 Complex in Homologous Recombination and Telomere Maintenance
… maintenance of chromosomes (SMC) family of proteins has been implicated in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR). The SMC1/3 cohesin complex promotes HR by localizing to DSBs where it holds sister chromatids in close proximity to allow HR-induced …
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Investigating the control of pairing and crossover formation in meiosis of Arabidopsis thaliana
… and controlled remains poorly understood. Telomeres are thought to play a role in pairing of homologues. The role of telomeres was investigated in Arabidopsis by treatment with colchicine, a microtubule-depolymerising drug, known to disrupt telomere clustering and pairing in rye. A mutant …
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Distinct Functions of POT1 in Telomere Protection and Length Regulation
<p>Telomeres are DNA-protein structures that protect eukaryotic chromosome ends from illegitimate recombination and degradation. Telomeres become shortened with each cell division unless telomerase, a reverse transcriptase, is activated. In addition to playing a protective role of chromosome ends, …
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Structural dynamics of telomeric overhang accessibility
Telomeres are dynamic nucleoprotein complexes that cap and protect chromosome ends from deleterious degradation and fusion events. In most eukaryotes, telomere length is regulated by a basal level of telomerase, a specialized reverse transcriptase, which can add telomeric repeats to the 3’ end of …
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The Apollo Nuclease Binds To TRF2 and Protects
<p>Members of the β-CASP family of proteins are involved in DNA repair and RNA processing. We identified a member of this family of enzymes, hSNM1B/Apollo, in complex with the telomere binding proteins TRF2/Rap1. Due to its low abundance at telomeres, we consider Apollo to be a telomere accessory …
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Flap Endonuclease 1 ensures telomere replication and stability
Telomeres, protein-DNA structures that distinguish the end of a chromosome from a bona fide DNA double strand break, are integral to genomic stability. High fidelity replication of telomeres is indispensable for their stability. Telomere replication is a challenging task that is completed through …
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Telomere Dynamics and End Processing in Mammalian Cells
Telomeres are repetitive DNA sequences that end in single-stranded 3' overhangs. With each cell division, normal human cells lose a small amount of telomeric DNA due to the end-replication problem and the action of an unidentified nuclease. In order for tumor cells to divide indefinitely, they …
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Distinct functions of POT1 at telomeres.
Telomeres are nucleoprotein complexes that constitute the ends of eukaryotic chromosomes. Telomeres differentiate the end of the chromosome from sites of DNA damage and control cellular replicative potential. The loss of function of telomeres results in several biological consequences. First, …