Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 32 for “"telomere shortening"”.
-
Genetic and Molecular Studies of Endometrial Cancer
… TP53 mutations, which suggests a link between telomeres and the development of type II tumors. Telomeres and other markers of telomere status in type I and type II tumors were analyzed, short telomeres are observed in both tumor types. However, only type II tumors are associated with critical …
-
Telomere Position Effect in Human Cells
Telomeres are tracts of repetitive DNA that cap the ends of linear chromosomes. Each time the chromosome is duplicated, a small amount of telomeric DNA is lost from the end due to factors inherent in the mechanism of DNA replication. The result is a net shortening of telomeres with each cell …
-
A Critical Review of Telomerase Biology and Model Systems for the Study of Telomerase
The study of telomere and telomerase biology holds substantial promise in uncovering the molecular process of aging and the treatment of cancers. Studies have shown that telomere shortening is directly linked to cellular aging and that telomerase expression is found in over 85% of human cancers, …
-
On the Second Telomere Maintenance Machine: Structure, Recruitment, and Regulation of the CST–Polα/primase C-strand Fill-in Complex
<p>Telomeres are the terminal nucleo protein components of eukaryotic chromosomes that safeguard genome integrity. Human telomeric DNA consists of double-stranded (ds) 5'-TTAGGG-3' repeats terminating in a 3' single-stranded (ss) overhang of the G-rich strand.The sequence and structure of the …
-
Functional analyses of hTel2 and TRF2 deltaB: Insights Into the Role of a New DNA Damage Pathway and Homologous Recombination in Mammalian Telomere Function
<p>Tel2 influences telomere length in S. cerevisiae and DNA-damage signaling in C. elegans. We found that endogenous human Tel2 (hTel2) localized in a diffuse, granular patter to the nuclei of human cells where it was enriched in PML nuclear bodies, but telomeres. Surprisingly, hTel2 also localized …
-
The Role of Pot1 in Telomere Protection and Maintenance
… telomeric DNA binding protein implicated in telomere length regulation in human cells. To address the role of POT1 in telomere protection we used RNAi in human cells. We confirmed that POT1 acts as a negative regulator of telomerase and showed that POT1 is required to protect telomeres. …
-
Preclinical Studies of Telomerase Inhibitor Imetelstat in Non-small Cell Lung Cancer
… to add the TTAGGG hexameric repeats to elongate telomeres and compensate for the loss of telomeres each cell division caused by the end replication problem. Imetelstat is an oligonucleotide designed to bind the hTR telomerase template component and inhibit telomerase leading to progressive …
-
Regulatio of actin cytoskeleton by TIS21 vi downregulating reactive oxygen species (ROS) in the doxorubicin-induced premature senescenc
… Cellular senescence is induced by DNA damage, telomere shortening or oncogene activation. During cellular senescence BTG2 is stabilized in response to telomere dysfunction. Doxorubicin is an effective anticancer drug that belongs to a class of anthracyclines and a commonly used inducer of DNA …
-
Understanding the Effect Of 1,3-Butadiene on Human Lung Fibroblasts: Does Exposure to 1,3-Butadiene Induce Senescence?
… of irreversible growth arrest induced by either telomere shortening (replicative senescence) or telomere-independent signals (stress-induced premature senescence or SIPS). Recent studies have shown that cigarette smoke extract induces senescence in lung fibroblasts and alveolar epithelial cells. …
-
Premature vascular senescence during diabetic retinopathy
… (SASP) and triggered by mechanisms such as telomere shortening and DNA damage. Diabetes is associated with endothelial dysfunction, which is characterised by increased vascular permeability, deficit in blood perfusion, vessel loss and increased inflammation. Cellular senescence has been …
-
Mechanisms and Consequences of Chromosomal Instability in Malignant tumours
In this thesis, telomere deficiency with subsequent anaphase bridging was found to be associated with chromosomal instability in established colorectal cancer cell lines and in Wilms tumour. In colorectal cancer cell lines, anaphase bridging was observed to generate both numerical and structural …
-
Antigenic Variation and Telomere Structure in Trypanosoma brucei
… throughout the genome, a few are located at telomere loci called expression sites (ESs) and only one is expressed at any time, suggesting a stringent regulatory mechanism. Here, it is demonstrated that trypanosomes engineered to express two VSGs simultaneously from the same ES can multiply in …
-
Defining Multiple Steps in Human Telomere End Processing
Telomere overhangs are essential for chromosome end protection and telomerase extension, but how telomere overhangs are generated is unknown. Due to the classic end replication problem, leading DNA daughter strands are initially blunt while lagging daughters are shorter by at least the size of the …
-
Telomere-Driven Tetraploidy and its Relevance to Cancer
… of tetraploidization in cancer, originating from telomere dysfunction, a widespread phenomenon in early tumorigene sis. Prolonged telomere deprotection caused by inactivation of the telomeric proteins POT1a and POT1b leads to tetraploidy in p53/Rb de cient mouse cells. Irreversible telomere …
-
ZSCAN4 AND REPLICATION STRESS: SAFEGUARDING GENOME STABILITY IN MOUSE EMBRYONIC STEM CELLS
… plays a crucial role in mESC by contributing to telomere maintenance and genomic stability. Its prolonged knockdown leads to cell death, accompanied by karyotype abnormalities and telomere shortening. Moreover, deregulation of Zscan4 has been implicated in cancer development and maintenance. …
-
Telomere Length Studies in Human Cancer Cells
Telomeres consist of repetitive DNA sequences and their associated binding proteins, and serve to protect linear chromosome ends from being recognized as double stranded breaks in need of repair. The telomeres of most normal diploid cells shorten with every cell division until they reach a …
-
Development of embryonic stem cells expressing endogenous levels of a fluorescent protein fused to the telomere binding protein TRF1
Telomeres are the repetitive DNA sequence and associated proteins found at the ends of linear chromosomes. They have a role in biological processes including meiosis and aging as well as implications in a number of genomic instability disorders and cancers. Telomeres maintain genomic stability by …
-
Distinct functions of POT1 at telomeres.
Telomeres are nucleoprotein complexes that constitute the ends of eukaryotic chromosomes. Telomeres differentiate the end of the chromosome from sites of DNA damage and control cellular replicative potential. The loss of function of telomeres results in several biological consequences. First, …
-
Regulation of Human Telomerase Alternative Splicing
… adds TTAGGG repeats onto chromosome ends (telomeres). Since telomerase is expressed in ~90% of all human cancer cells while being absent in most somatic tissues, telomerase is an almost universal cancer therapeutic target. Yet, the clinical application of an effective telomerase inhibitor …
Page 1 of 2