Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"telomere length"”.
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Exposure, telomere length, and cancer risk
Telomeres are tandem repeats of TTAGGG at the end of eukaryotic chromosomes. Telomeres play a key role in chromosome stability and regulation of the cellular lifespan. Telomeres are shortened during cell division, and probably, by not yet well characterised factors in the environment. Short …
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Telomere Length Studies in Human Cancer Cells
Telomeres consist of repetitive DNA sequences and their associated binding proteins, and serve to protect linear chromosome ends from being recognized as double stranded breaks in need of repair. The telomeres of most normal diploid cells shorten with every cell division until they reach a …
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Estimating telomere length from whole genome sequencing data
… the development of two computational tools, Telomerecat and Parabam, as well as their applications to whole genome sequencing (WGS) data. Telomerecat is a tool for estimating telomere length from WGS data. The strength of Telomerecat lies in its applicability. This applicability is due to a …
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Functional Analysis of the Yku Complex in Telomere Length Regulation
… It contributes to the maintenance of wild type telomere length and, moreover, has been implicated in the protection of the telomeres from end-to-end fusions. Telomere-bound Yku delocalizes from telomeric foci in response to DNA damage and accumulates at the sites of a DNA break. This thesis …
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Effects of Stress Coping Mechanisms on Telomere length: A literature review.
Studies of telomeres in humans are inconsistently related to exposure to stressors but strongly related to cell life cycle and cell senescence. Cell level stressors are related to reductions in telomere length as well as some social stressors showing moderate associations with telomere length. …
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Aurora A nuclear expression and telomere length in BRCA2 related breast cancer
… A yfirtjáning í brjóstaæxlissýnum og hins vegar telomere lengd í blóðsýnum frá brjóstakrabbameinssjúklingum með og án BRCA2 999del5 stökkbreytingar. Aurora A kjarnatjáning var metin með mótefnalitun á vefjaörflögum í alls 396 brjóstaæxlum, þar af voru 112 með BRCA2 999del5 kímlínubreytinguna og …
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Chromosome-Specific Telomere Length in Women with Breast Cancer: Their Relationship to Chemotherapy and Acquired Psychoneurological Symptoms
… symptoms’’ (PN). Given that acquired telomere attrition has been speculated to be a causal factor in chronic diseases and the lack in the literature of mechanisms giving rise to PN symptoms, this study was performed to assess telomere length using a chromosome-specific telomere assay …
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Social-Demographics, Health Behaviors, Telomere Length In Mexican-American Cohort and Circulating Dna Methylation In Bladder Cancer
… SOCIAL-DEMOGRAPHICS, HEALTH BEHAVIORS, AND TELOMERE LENGTH IN MEXICAN AMERICANS: A COHORT STUDY</strong></p> <p>Recent studies using a prospective cohort design have suggested that telomere length in peripheral blood leukocytes is not only a potential indicator of cellular aging that has …
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From the End to the Middle: Regulation of Telomere Length and Kinetochore Assembly by the RNR Inhibitor SML1
… dNTP regulation, including sml1∆, play a role in telomere length homeostasis. Reduction in total dNTP concentration results in a modest decrease in telomere length, while altering the ratios between the four dNTPs has a much more pronounced effect. The altered telomere lengths correlate with the …
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Further Insight into the Two Functions of Telomeres: Determining the Role of Tankyrase1 in Telomere Length Regulation and Tin2 in Telomere Protection
… poly(ADP-ribose) polymerase that can localize to telomeres through its interaction with the shelterin component TRF1. Tankyrase1 poly(ADP-ribosyl)ates TRF1 in vitro, and its nuclear overexpression leads to loss of TRF1 and telomere elongation, suggesting that tankyrase1 is a positive regulator of …
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Ageing in dogs (canis familiaris) and its relationship to their environment
… investigated the levels of cor-tisol, relative telomere length and the association of these variables with the perception of canine age (apparent age). Firstly, it was investigated whether dogs’ telomere lengths from dried blood correlated with the ones measured from oral swabs from the same …
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Avian telomere dynamics
Telomeres, the repetitive DNA sequences that cap eukaryotic chromosomes, are thought to play an important role in linking life conditions and senescence. In vertebrate somatic cells, telomeres shorten at each cell division, and the rate at which they do so has been linked to cellular and organismal …
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Romantic conflict, interpersonal mindfulness, and cellular aging
… and cellular aging processes measured through telomere length (Rentscher et al., 2020). Despite established associations between romantic conflict and health outcomes (Cummings et al., 2007), empirical evidence has yet to emerge supporting a link between romantic conflict and telomere length. …
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T-lymphocyte senescence and hepatitis C virus infection
… phenotypic and functional changes, including telomere shortening. Short telomeres are associated with poor proliferative capacity, pro-inflammatory responses and increased mortality in clinical studies. This research aimed to study telomere length changes in T-lymphocytes in chronic HCV …
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Telomere Dynamics of Grey Seals (Halichoerus grypus) on Sable Island, Nova Scotia: a Long-Lived Marine Mammal Population Island
Telomeres are highly conserved structures on the terminal ends of linear chromosomes that are essential to normal cell function. Loss in telomere length occurs with age in somatic tissues and is exacerbated by sources of stress, particularly during early life. Loss in telomere length with age is …
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Distinct Functions of POT1 in Telomere Protection and Length Regulation
<p>Telomeres are DNA-protein structures that protect eukaryotic chromosome ends from illegitimate recombination and degradation. Telomeres become shortened with each cell division unless telomerase, a reverse transcriptase, is activated. In addition to playing a protective role of chromosome ends, …
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Prediction of age from DNA
… if one could use a correlation between telomere length and age, to predict the age of an individual from their DNA. Telomere length, in buccal cells, of 167 individuals aged between 1 and 96 years old was measured using quantitative real time PCR. The causes for the presence of large …
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Changes in buccal cytome biomarkers in relation to ageing and Alzheimer’s Disease.
… profile of the buccal mucosa. Changes in telomere length were investigated using a quantitative RTm-PCR method to measure absolute telomere length (in Kb per diploid genome) and show agerelated changes in white blood cells and buccal cell telomere length (in kb per diploid genome) in …
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Molecular and Genetic Analysis of the Role of Ku in Silencing and Telomere Function in Saccharomyces Cerevisiae
The binding of Ku at the telomere is an integral part of maintaining the specialized chromatin structure required for genomic stability at the telomeres. To gain further insight into the signals and complexes involved in the multiple processes contributing to normal telomere function, we performed …
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