Global ETD Search
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Showing 1 to 7 of 7 for “"telomere function"”.
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Cell cycle-dependent modification of Pot1 and its effects on telomere function
Telomere functions are tightly controlled throughout the cell cycle to allow telomerase access while suppressing a bona fide DNA damage response (DDR) at linear chromosome ends. However, the mechanisms that link cell cycle progression with telomere functions are largely unknown. Here we show that a …
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Molecular and Genetic Analysis of the Role of Ku in Silencing and Telomere Function in Saccharomyces Cerevisiae
The binding of Ku at the telomere is an integral part of maintaining the specialized chromatin structure required for genomic stability at the telomeres. To gain further insight into the signals and complexes involved in the multiple processes contributing to normal telomere function, we performed …
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Functional analyses of hTel2 and TRF2 deltaB: Insights Into the Role of a New DNA Damage Pathway and Homologous Recombination in Mammalian Telomere Function
<p>Tel2 influences telomere length in S. cerevisiae and DNA-damage signaling in C. elegans. We found that endogenous human Tel2 (hTel2) localized in a diffuse, granular patter to the nuclei of human cells where it was enriched in PML nuclear bodies, but telomeres. Surprisingly, hTel2 also localized …
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Characterization of DNA Binding Activities at Vertebrate Telomeres
<p>Telomere function is carried out by protein factors that either bind directly to telomeric DNA or that are recruited there by DNA binding activities. Thus, telomeric DNA binding activities are central to telomere function. Two types of vertebrate DNA binding activities are characterized in this …
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Examination of molecular genetic factors involved in sensitivity to breast cancer following radiation exposure
… radiation exposure, DNA repair deficiency and telomere malfunction are associated with cancer risk, we investigated Lymphoblastoid Cell Lines (LCLs) from breast cancer patients and controls for chromosomal radiosensitivity, relative telomere length, and gene expression changes. The importance …
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Telomere Dynamics and End Processing in Mammalian Cells
Telomeres are repetitive DNA sequences that end in single-stranded 3' overhangs. With each cell division, normal human cells lose a small amount of telomeric DNA due to the end-replication problem and the action of an unidentified nuclease. In order for tumor cells to divide indefinitely, they …
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Drivers of melanoma susceptibility
… these analyses suggested that genes regulating telomere function could be influencing melanoma risk. After performing functional experimental analyses, our research team was able to determine that carriers of rare variants in the protection of telomeres (POT1) gene, a member of the shelterin …