Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 119 for “"telomerase"”.
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Evaluation of telomerase activity and telomerase inhibitors in Head and Neck cancer
… this disease. This thesis focuses on the enzyme telomerase which is known to contribute to one of the hallmarks of cancer (immortality). Elevated telomerase activity has been observed in the majority of cancer cells but not in most normal human cells so there is an opportunity to use telomerase …
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A Critical Review of Telomerase Biology and Model Systems for the Study of Telomerase
The study of telomere and telomerase biology holds substantial promise in uncovering the molecular process of aging and the treatment of cancers. Studies have shown that telomere shortening is directly linked to cellular aging and that telomerase expression is found in over 85% of human cancers, …
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Regulation of Human Telomerase Alternative Splicing
Telomerase adds TTAGGG repeats onto chromosome ends (telomeres). Since telomerase is expressed in ~90% of all human cancer cells while being absent in most somatic tissues, telomerase is an almost universal cancer therapeutic target. Yet, the clinical application of an effective telomerase …
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Telomerase Activity in Human Preimplantation Embryos
<p>Telomerase, a ribonucleoprotein, has been described as an essential component of highly proliferative cells, which stabilizes the telomeres and avoids cellular senescence. Telomerase has been identified in various embryonic cell stages, hematopoietic cells, and in >85% of tumor tissue biopsies …
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Targeting Telomerase Overexpression by Synthetic Dosage Lethality
Telomerase reverse transcriptase (hTERT) is upregulated in multiple cancers and accompanied by the evidence suggesting that up-regulation of telomerase expression is linked to tumorigenesis, raised the hypothesis that inhibiting this enzyme is a powerful antitumor strategy. Despite intensive …
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Neotelomere Formation by Telomerase in Human Cells
… the shelterin complex. The reverse transcriptase telomerase counteracts the shortening of telomeres that occurs with cell division due to incomplete DNA replication and nucleolytic resection. During human development, the expression of the reverse transcriptase component of telomerase (TERT) is …
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Telomerase a prognostic marker an therapeutic target
… of tumours and is usually refractory to therapy. Telomerase and its altered activity, distinguishing cancer cells, is an attractive molecular target in glioma therapeutics. The aim of this thesis was to silence telomerase at the genetic level with a view to highlight the changes caused in the …
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Telomerase Inhibition and Sensitization of Breast Tumor Cells
Telomerase, a ribonucleoprotein enzyme minimally composed of an RNA template (hTR) and a catalytically active protein subunit (hTERT), synthesizes telomeric repeats onto chromosome ends and is obligatory for continuous tumor cell proliferation, as well as malignant progression of breast cancer …
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REGULATION OF TELOMERASE EXPRESSION IN STEM CELL REPROGRAMMING
… them from normal fibroblasts and their lack of telomerase shows their limited proliferation capacity, the expression of genes closely linked to pluripotency and their differentiation capacity clearly define ASCs as multipotent stem cells. iPS cells are another promising cell type for tissue …
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Telomere and Telomerase Dynamics in Human T Lymphocytes
… To compensate for the loss of telomeres, telomerase is a ribonucleoprotein enzyme complex that elongates telomeres, but its expression is restricted to certain subsets of cell types. Investigating how telomerase is regulated in normal cells may provide insights and new approaches to block …
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Biochemical and structural studies of human telomerase regulation
Telomerase is a ribonucleoprotein (RNP) enzyme that extends telomeric repeats at eukaryotic chromosome ends (Blackburn and Collins, 2011; Blackburn et al., 2006; Greider et al., 1985; Morin, 1989; Nguyen, 2021). This counterbalances telomere loss caused by incomplete genome replication (Blackburn …
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Suppression of telomerase component dyskerin in human haematopoietic progenitor cells
Telomerase is a multi-component enzyme functioning to maintain chromosomal-end structures, called telomeres. Telomerase insufficiency, due to mutations in telomerase associated genes including dyskerin (encoded by DKC1) and TERC, is a hallmark of a subgroup of inherited and acquired haematopoietic …
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Glioma genetic profiling: The role of DNA repair and telomerase
… specifically targeting immortalisation (telomerase). 1[mmortalisation not only requires telomerase but also an imbalance/inactivation of DNA repair functions such as 06 methylguanine-DNAmethyltransferase (MGMI) which is a major obstacle with regards to glioma chemotherapy. The primary …
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Repair of DNA Double-Strand Breaks in Chromosomes: Impact of Telomerase
No abstract prepared.
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Repression of telomerase components in isogenic normal, immortal and tumorigenic cells
The telomere maintenance enzyme telomerase is a ribonuclear protein complex that is active in 80-90% of immortal cancer cells. Three essential components of the active telomerase holoenzyme include the reverse transcriptase, hTERT, an RNA component (hTR) that has a template region for reverse …
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INTERROGATING THE ROLE OF N6-METHYLADENOSINE RNA MODIFICATION ON TELOMERASE BIOLOGY
Telomerase is a multisubunit ribonucleoprotein complex that is used by most eukaryotes to restore the terminal DNA of chromosomes lost during replication. The RNA subunit of telomerase, TERC, hTR acts as a template for its reverse transcriptase activity and as a scaffold for the binding of proteins …
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Preclinical Studies of Telomerase Inhibitor Imetelstat in Non-small Cell Lung Cancer
Telomerase is expressed in ~90% of all cancers but is not expressed in most somatic cells making it an attractive target for cancer therapy. Telomerase has two essential components, a reverse transcriptase (hTERT) and an RNA template (hTR or hTERC). The RNA template is used by the reverse …
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Hemmung der humanen Telomerase Reverse Transkriptase-Expression mittels synthetischer Nukleinsäuren in Harnblasenkarzinomzellen
… des potenziellen Targetgens hTERT (humane Telomerase Reverse Transkriptase) mit AS-ODN und siRNAs in BCa-Zellen untersucht. Die Tumorspezifität der hTERT-mRNA-Expression konnte zunächst an tumor- und tumorfreien Gewebeproben von BCa-Patienten gezeigt werden. Die verwendeten AS-ODN …
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The Dietary Isoprenoid Perillyl Alcohol Inhibits Telomerase Activity in Prostate Cancer Cells
… compound–perillyl alcohol regulates telomerase activity via the mammalian target of rapamycin (mTOR) pathway in prostate cancer cells. Telomerase–the enzyme responsible for immortalizing cells through telomeric repeats addition–is de-repressed early in an aspiring cancer cell. We …
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Consequences of telomerase inhibition and telomere dysfunction in BRCA1 mutant cancer cells
… this study was to determine whether GRN163L, a telomerase inhibitor, currently in clinical trials for the treatment of cancer, has enhanced anti-cancer activity in BRCA1 mutant breast/ovarian cancer cell lines compared to wild-type cancer cells. BRCA1 mutant cancer cells were observed to have …
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