Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"tcf7l2"”.
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Specific forms of TCF7L2 protein define the Wnt pathway dependent genetic program
The TCF7L2 transcription factor is a critical regulator of Wnt pathway-dependent gene expression in the intestinal epithelia. Mutations in TCF7L2 have been previously reported in colorectal cancer, however their functional impact on tumour biology has not been investigated. The present work has …
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An emerging role for tcf7l2 at the nexus between metabolic regulation and social behavior
… factors (TFs), most notably the WNT regulator, TCF7L2. Tcf7l2 has been linked to neurodevelopmental disorders, but importantly, is also the single gene that is most highly associated with human metabolic disorders as well. These data focused my attention on understanding the role of TCF7L2 in …
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Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes
… T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of T2DM was unclear. Clinical, animal and in vitro studies have revealed an association of the risk T-allele of rs7903146 with impaired β cell function including glucose- and …
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Genotipagem e análise da expressão do gene TCF7L2 em pacientes com alteração do crescimento fetal e doenças metabólicas no adulto.
… ao desenvolvimento dessas patologias, como o TCF7L2. Portanto, torna-se importante identificar a frequência dos principais polimorfismos desse gene (49080T>C, 103894G>T e 53341C>T) assim como analisar sua expressão em amostras de RNs com peso ao nascer alterado e de pacientes adultos obesos. …
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Investigating the Non-globular Proteins of the Canonical Wnt Signalling Pathway
… kinase 2 (LRRK2) and the transcription factor TCF7L2 within this signalling pathway. LRRK2 is a large multi-domain protein with strong links to Parkinson’s disease and suggested to play a role in inactivating the BDC in response to the Wnt signal. A recent paper proposed that the previously …
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Genetic Variations in Type 2 Diabetes and Cardiovascular Disease: A Focus on Gene-Lifestyle Interactions and Mendelian Randomization
… assessment between the years 1991-1996. The TCF7L2 genotype modified the association between fiber intake and the risk of T2D. The lower risk of T2D by higher fiber intake was restricted to individuals carrying the CC non-risk genotype (Pinteraction = 0.049). Similar interaction was observed …
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Regulation of Wnt signalling in ovarian cancer and immune cells
… the expression of TCF7 and the less studied TCF7L2, both Wnt transcription factors of the TCF/LEF family, in different immune subsets. I focus on the detection and the differential expression of extended and short isoforms of these transcription factors and find unique expression patterns in …
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The genetic background of gestational diabetes mellitus
… alleled, the transcription factor 7-like 2(TCF7L2) rs7903146, rs12255372 and rs7901695 SNPs, the 1858 C>T SNP of the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene and we tested for the presence of islet cell autoantibodies against glutamic acid decarboxylase 65 (GAD65), …
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Investigation of Genetic and Behavioural Determinants of Type 2 diabetes and Glycaemic Traits
… genetic variant was at the established TCF7L2 locus. I then used the profiling of behavioural factors in the EPIC-InterAct study to show that there was no interaction between TCF7L2 genetic variants and an index of the number of health behaviour goals achieved, a measure that was …
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Exploring the Grey Zone between Type 1 and Type 2 Diabetes
… develop vascular and neuropathic complications. TCF7L2 is by far the strongest T2D-associated gene. Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes inherited in an autosomal dominant fashion (individual has one copy of a mutant gene and one normal gene on a pair of …
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The Potential Role of Insulin (and Stress Response) Pathway Components In Breast Cancer Development and Progression
… pathway genes, IGF1, TSC1, IGFBP2, IRS1, TCF7L2, IGF1R, and PPARA, if significantly associated with tumor receptor status, provide evidence for a connection between insulin metabolism and the determination of breast tumor subtypes. The CC genotype of the TSC1 polymorphism rs7874234 was …
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Identifying Genes in Pancreatic Beta-Cell Function using a Novel High-Thoughput Cell-Based Screening Assay
… secretion to the polymorphisms within the TCF7L2 gene. In addition, an active Wnt signaling pathway was suggested in the mouse and human pancreas by the confirmed expressions of several Wnt and Frizzled isoforms, along with the evidence highlighting the requirement of the co-receptor LRP5 …
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Mechanisms of defective insulin secretion in type 2 diabetes
… that genetic variants for type 2 diabetes near TCF7L2 and ADRA2A were associated with reduced glucose-induced insulin secretion. Moreover, susceptibility variants near ADRA2A, KCNJ11, KCNQ1, and TCF7L2 were associated with reduced depolarization-evoked insulin exocytosis. We combined our results …
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Defining the minimal and context-dependent signalling cascades regulating the maintenance of human naïve embryonic stem cells and early embryo development
… but primed ES cells readily express TCF7L1 and TCF7L2. Trophoblast-like cells robustly express TCF7L2 and hypoblast-like cells express LEF1. Interestingly, NANOG-positive cells in hypoblast-like cell cultures feature TCF7 expression, suggesting that it might be a target of active WNT/β-Catenin …
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TCF4-mediated Transcriptional Regulation of Krüppel-like Factor 4 Gene
… motif를 확인하였다. Transcription factor 7-like 2(TCF7L2)로 알려진 TCF4은 transcription factor의 하나이고, 성인의 장에서 Wnt/β-catenin 신호 전달 활동을 중재하고, 결장 표면에서 발현되는 primary TCF/LEF family member이다. KLF4 유전자의 변화활동이 TCF4에 의해서 중재되는지 알아보기 위해, Western blot 실험을 통해 HCT116 세포와 HEK293 세포에서 TCF4 발현을 관찰하였다. TCF4 단백질이 HCT116 …
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Enhanced care to people of South Asian Ethnicity-the United Kingdom Asian Diabetes Study (UKADS)
… association with the common polymorphisms of the TCF7L2 gene. Studies for associations with other susceptibility genes with small effect sizes (PPARG, PPARG1A, CALPAIN10 ) were not adequately powered to detect possible associations.
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Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion
… a risk score consisting of 4 SNPs in or near TCF7L2, KCNJ11, ADRA2A and KCNQ1 that successfully predict reduced exocytosis, calcium-sensitivity, granular docking and GSIS. Finally, in paper V, knock-down of rno-microRNA-335 in insulin-secreting cells was found to increase Stxbp1 expression …
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An investigation of genetic polymorphism in association with Type 2 diabetes and metabolic syndrome.
… rs7903146 of Transcription Factor 7 Like 2 (TCF7L2) gene, rs9939609 of Fat mass and obesityassociated (FTO) gene and rs1801282 (Pro12Ala) of peroxisome proliferatoractivated receptor gamma (PPARG) gene with the metabolic syndrome and its components has been studied in the Nepalese population. …
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Genetics of Type 2 Diabetes and Metabolic Syndrome: From Genome Wide Linkage Scan and Candidate Genes to Genome Wide Association Studies
… V, polymorphisms in candidate genes for T2D (TCF7L2, WFS1, IGF2BP2) and obesity (FTO) predicted development of MetS and the risk to develop MetS seemed to be driven by associations with the previously reported phenotypes. These data do not support the view that the different components of MetS …
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IDENTIFYING GENES THAT CONTRIBUTE TO TYPE 2 DIABETES SUSCEPTIBILITY IN CAUCASIAN AND AFRICAN AMERICANS
… of admixture on association results. Apart from TCF7L2 (rs7903146, Pa=1.59x10-6), we observed little evidence of association with T2DM in AAs. In fact, only rs9300039 in an intragenic region of chromosome 11p12 was associated with T2DM after admixture adjustment (Pd=0.029). The primary objective …
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