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Showing 1 to 19 of 19 for “"taurocholate"”.
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Regulation des renalen Natrium-abhängigen Gallensäuren-Transporters (ASBT) durch Sexualhormone und Glukokortikoide
… the ASBT-mediated transport of the bile acid taurocholate is regulated by sex hormones or glucocorticoids. In-vitro uptake experiments with freshly isolated proximal tubular cells from female and male sprague-dawley rats and in-vivo clearance experiments were performed using the radioactive …
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Charakterisierung des Gallensäuretransporters ASBT am Oozyten-Expressionssystem
… Highest correlation was obtained by assuming taurocholate to sodium ratio of one: two. This clearly opposes the previous theory of a electro neutral transport. Time dependence of taurocholate uptake into oocytes illustrated a constantly increasing uptake for three hours. Dependence of the …
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Taurocholat-Transport in isolierten proximalen Tubuluszellen der Ratte : Einfluss einer extrahepatischen Cholestase
… tubular cells could be obtained. Cellular 3H-taurocholate uptake was investigated with control conditions and after 24 h bile duct ligation. With control conditions, there was a concentration dependent cellular uptake of 3H-taurocholate. A maximum cell water/medium accumulation ratio of more …
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Investigation of the absorption pathways of some poorly absorbed drugs using human intestinal (CAC0-2) cell monolayers
… transport of D-glucose and Sodium taurocholate as well as the vesicularly transcytosed horseradish peroxidase was also investigated. As expected, 2 mM apical La3+ increases transepithelial electrical resistance 1.S-fold and decreases mannitol permeability by 63.0 % ± 1.37 %. This …
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Transport von Paraaminohippursäure, Furosemid, Hydrochlorothiazid, Cimetidin, 11-Deoxycorticosteron und Taurocholat an der basolateralen Membran proximaler Nierentubuli
… (HCT), cimetidine, 11-deoxycorticosteron and taurocholate) was determined on non-perfused proximal S2-Segments, microdissected from rabbit kidneys without use of enzymatic agents. To measure the transport rate, we took advantage of the finding, that OATS1 acts as a counter-transporter, which …
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Regulation of to xin Synthesis By Clostridium Difficile
… levels of the common human conjugated bile salt, taurocholate, was found to inhibit toxin A and B <em>in vitro</em> activities. When co-incubated <em>ex vivo</em> with purified toxin B, taurocholate protected Caco-2 colonic epithelial cells from the damaging effects of the toxin. Furthermore, …
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Understanding the transport mechanisms of BSEP to improve the prediction of DILI compounds
… compounds showed competitive inhibition of taurocholate transport in Lineweaver-Burk plots but also other types of inhibition in Eadie-Hofstee plots. These results indicate that these inhibitors might compete with taurocholate for binding in the substrate-binding pocket and possibly, that …
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Antigenic and functional differences between the polar and lateral flagella of Azospirillum brasilense
… EDTA, sodium deoxycholate, sodium taurocholate, and Na₂SO₄, at appropriate concentrations could inhibit swarming without preventing growth. Based on the use of mutants lacking either the polar flagellum or the lateral flagella, the lateral flagella were found to be responsible for …
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Signaling and Adhesive Mechanisms in Acute Pancreatitis
… was induced by retrograde infusion of taurocholate into the pancreatic duct in different mice strains to elucidate the role of toll-like receptor 2 (TLR2), TLR4, lymphocyte function antigen-1 (LFA-1), matrix metalloproteinases (MMPs) and Rho-kinase as well as nuclear factor of activated …
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Isoprenylation and NET formation in acute pancreatitis
… in mice was induced by retrograde infusion of Na-taurocholate into the pancreatic duct and intraperitoneal injection of L-arginine two times at hourly intervals. Induction of pancreatitis provoked a clear cut increase in tissue damage of the pancreas characterized by neutrophil infiltration, …
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CHEMICAL AND PHYSICAL CHARACTERIZATION OF COMPLEX III; THE OXIDATIVE REACTION MECHANISM
… per pH unit was observed for both b species in taurocholate buffers. These two detergents also produced different MCD-contributions of the two b hemes. The oxidative reaction mechanism was investigated through the reoxidation of 2-electron, 4-electron (CoO-depleted) and fully-reduced Complex III …
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Microbial pathways of sulfur metabolism and colorectal cancer risk
… of metabolizing the taurine conjugated bile acid taurocholate (TCA), and were housed at the Mayo Clinic Gnotobiotic Facility for 30 days. A transcriptome analysis of cecal content revealed 4099 transcripts expressed by B. wadsworthia. Transcripts were observed for all three enzymes involved in …
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Minimization of extracellular enzyme production by Pseudomonas fluorescens in a model milk system by controlled oxygen atmospheres
… at final concentrations of 15 mM sodium taurocholate and 8 mM 13-naphthylcaprylate in the reaction mixture and a solvent system of 60:40 ethyl acetate to ethanol. A final concentration of ethylenediamine tetraacetic acid between 2 and 5 rnM minimized degradation of lipases by proteinases …
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Targeting Organic Anion Transporting Polypeptide 1A4 (Oatp1a4) for Effective Drug Delivery at the Blood-Brain Barrier
… of established Oatp transport substrates (i.e., taurocholate, atorvastatin, pravastatin). Of particular significance, we have elucidated that BMP-9 activates the canonical TGF-β/ALK1 signaling pathway in brain microvessels as indicated by increased nuclear translocation of specific Smad proteins …
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Effects of weight loss while feeding a moderate-protein, high-fiber diet on body composition, voluntary physical activity, and blood metabolite profiles in overweight cats
… and dramatic reduction of bile acids (cholate; taurocholate; deoxycholate) with weight loss. A reduction in numerous non-esterfied fatty acids (NEFA) and an increase in ketones (acetoacetate; 3-hydroxybutryate) and monoglycerides suggested a shift toward lipolysis and hepatic NEFA oxidation. …
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The intestinal absorption of n-3 and n-6 polyunsaturated fatty acids: proposed mechanisms from studies using human Caco-2 cells.
… that the LCFA solubilisation of in 10 mM sodium taurocholate solutions buffered between pH 6.8 and 7.0, allows a high, rapid and reproducible cellular uptake, over short incubation periods without affecting cell viability. After the optimisation of the study design, the process of the LCUFAs …
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Role of dry beans (Phaseolus vulgaris L.) in binding bile salts and modulating lipid digestion: Impact of the bean matrix and high-hydrostatic pressure processing
… the largest retention levels while sodium taurocholate being the least effectively retained BS by beans. Diverse sequences of the same processing operations showed distinct impacts on BS-retention by dry beans. By means of an in vitro digestion model simulating conditions in the upper …
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In-Vivo and In-Vitro Cholesterol Removal by Lactobacilli and Bifidobacteria
… deconjugation of sodium glycocholate than sodium taurocholate. BSH activity indicated that substrate specificity was also more towards glycine-conjugated bile compared to taurineconjugated bile. Most strains of lactobacilli and bifidobacteria exhibited highest total BSH activity (1.60-1.99 U/mL …
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Engineering nanocarbon interfaces for electron transfer
… exclusion effects are dominant. Here, sodium taurocholate exhibits almost no reactivity under the explored reaction conditions, while for sodium deoxycholate and sodium taurodeoxycholate, we show that the greatest extent of reaction is observed among a small population of nanotube species, …