Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"tau proteins"”.
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Topology and geometry-based methods for quantifying the complexity of protein structures
… systems of filaments, such as those formed by proteins. In this dissertation we employ tools from knot theory in combination with available experimental data and molecular simulations to analyze the topological complexity of tau proteins. These proteins are involved in a class of …
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Synaptic Excitatory to Inhibitory imbalance in Alzheimer’s Disease
… and abnormal aggregation of amyloid beta and tau proteins. Notably, prodromal Alzheimer’s disease is characterized by mild cognitive impairment, increments in the occurrence of seizures and abnormal electroencephalographic activity. Clinical and animal model studies suggest that …
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Investigating KCC2 activity in Amyloid Precursor Protein (APP) associated Alzheimer’s Disease
… the expression levels and alterations of these proteins affect the physiological expression and regulation of each other. In addition, this chapter suggests that APP expression and regulation may have consequential effects on key proteins involved in the regulatory pathways for KCC2 activity, …
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A Genome-Wide Screen on Modifiers of Tau-Induced Neurodegeneration Using RNAi-Mediated Gene Silencing in Drosophila
Intraneuronale Akkumulationen des Tau-Proteins sind ein gemeinsames Merkmal der sogenannten Tauopathien. Frontotemporale Demenz und Parkinsonismus des Chromosoms 17 (FTDP-17) ist eine Tauopathie, die durch verschiedene Mutationen in dem für Tau kodierenden Gen verursacht wird. Die Pathologie von …
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Biophysical methods to study the ubiquitination of amyloidogenic proteins and proteasomal responses to protein aggregates
The accumulation of misfolded proteins is a universal mechanism in neurodegenerative diseases such as Parkinson’s disease (PD), Alzheimer’s disease (AD) and prion disease. In mammalian cells, the majority of misfolded proteins are degraded by the ubiquitin-proteasome system (UPS), in which …
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A study of the neurotoxicity of MPTP and analogs in human neuroblastoma SH-SY5Y cells
… and d-tubocurarine. MPTP caused increases in tau proteins, and also caused an increased expression of the reverse transcriptase polymerase chain reaction (RT-PCR) product after treatment for 2 to 5 days at 10⁻³ to 10⁻⁴ M. The results, for the first time, demonstrated that MPTP affected …
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On the Structure and Function of Tau Assemblies in Neurodegenerative Diseases
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Eyelid conditioning in mice reveals an interaction between stress and familial Alzheimer's disease
… Precursor Protein, Presenilin-1 (PS1) and tau proteins were conditioned at ages ranging from 3-16 months. Mutants displayed more rapid learning compared to controls at all ages tested. Additionally, 3xTg mice produced greater acoustic startle. Both behavioral phenotypes are consistent with …
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Amyloid seeding assays for the selective amplification of tau aggregates from human brain homogenates
The microtubule-stabilising protein tau misfolds and accumulates into amyloid inclusions in a diverse class of diseases called tauopathies. A growing body of biochemical and structural literature has now confirmed that tau takes different disease-specific aggregate conformations, which then …
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The Role of DnaJC7 in Modulating Tau Aggregation in the Cell
Appendix A contains a previously published manuscript, which is referenced below as a related citation.
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Mechanistic Investigation into the Regulation of Amyloid Motifs in Tau Aggregation and Disease
Amyloid formation of tau protein is a unifying theme in a multitude of neurodegenerative diseases, collectively called tauopathies. Missense mutations in the tau gene (MAPT) correlate with aggregation propensity and cause dominantly inherited tauopathies, but the molecular mechanism of how they …
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Mechanisms of Adsorption and Surface-Mediated Aggregation of Intrinsically Disordered Protein Tau at Model Surfaces
… of an intrinsically disordered soluble protein, tau, into insoluble filaments is a defining hallmark of many neurodegenerative diseases, commonly referred to as tauopathies. In its native state, the protein tau’s function is to promote the assembly, and aid in the stabilization of microtubules. …
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Analyse der Funktion von A-Ephrinen in der Entwicklung des Nervensystems an einem neu etablierten transgenen Mausmodell
… wurde nun das Mikrotubuli bindende Protein Tau gegen die cDNA des Rezeptorkörpers ersetzt (sog. knock-in), und nach Keimbahntransmission des rekombinanten Allels wurde durch Rückkreuzung gegen den Inzuchtstamm C57BL/6 eine congenische Mauslinie erzeugt. In dieser Mauslinie wurde der …
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Lessons from Tau RT–QuIC: Structure, Kinetics, and Drug Discovery
… of the microtubule–associated protein tau into filamentous inclusions is a hallmark of various neurodegenerative diseases collectively known as tauopathies. This group encompasses over 20 clinicopathological conditions, including Alzheimer’s disease (AD), which accounts for about 70% of …
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The Association Between Traumatic Brain Injury and Alzheimer's Disease: Mouse Models and Potential Mechanisms
… tangles: NFTs) composed of hyperphosphorylated tau proteins. Aβ is thought to act upstream of tau, affecting its phosphorylation and therefore aggregation state. One of the major risk factors for AD is traumatic brain injury: TBI). Acute intra-axonal Aβ and diffuse extracellular plaques occur in …
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The functional role of the retromer complex in the pathogenesis of Alzheimer's disease in Down syndrome
… with DS develop amyloid beta (Aβ) plaques and tau neurofibrillary tangles, the pathological hallmarks of Alzheimer’s disease (AD). This increased susceptibility to Alzheimer’s Disease in Down syndrome (AD-DS) has primarily been attributed to an over-dosage of the amyloid precursor protein …
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Apolipoprotein E and propagation of pathological tau in Alzheimer’s Disease
… (Ab) in plaques and hyperphosphorylated tau in neurofibrillary tangles. This occurs alongside neuroinflammation and neurodegeneration. Clinically, AD is typified by cognitive decline. Pathological tau propagates through the AD brain in a defined manner, with indications this occurs …