Global ETD Search
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Showing 1 to 8 of 8 for “"tau protein aggregation"”.
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Characterization of Oxidized Tau Protein Aggregation and Inhibition of Tau Aggregation via MAP2
… (NFT) composed of the microtubule stabilizing protein Tau are a pathological hallmark of Alzheimer's disease (AD) and many other dementia related diseases specified as Tauopathies. Due to alternative mRNA splicing, intrinsically disordered Tau exists as six separate isoforms in the adult human …
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Mechanisms of Adsorption and Surface-Mediated Aggregation of Intrinsically Disordered Protein Tau at Model Surfaces
The adsorption and aggregation of an intrinsically disordered soluble protein, tau, into insoluble filaments is a defining hallmark of many neurodegenerative diseases, commonly referred to as tauopathies. In its native state, the protein tau’s function is to promote the assembly, and aid in the …
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Innovative Alzheimer's disease clinical trial design in the coming age of biomarkers
… new targets including the amyloid beta and tau protein aggregation pathways in the brain. They have opened up a whole research field on biomarkers specific to these pathways. These biomarkers have however never been used to select a subpopulation that would enroll in clinical trials. This …
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Bioastronautics: Biological Modeling of the Neural Response to Space Radiation and its interaction with Alzheimer's Disease Risk Genes
… the beta-amyloid (Aβ) and phosphorylated tau protein aggregation characteristic of the disease, for use with the particle accelerator facility at the NASA Space Radiation Laboratory (NSRL). We show consistent changes in Alzheimer’s protein pathology and marked differences in RNA …
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USING B-STRAND AND B-HAIRPIN PEPTIDOMIMETICS INDUCED BY CONSTRAINED AMINO ACIDS TO MODULATE THE AGGREGATION OF THE MICROTUBULE ASSOCIATED PROTEIN TAU: DESIGN, SYNTHESIS AND EVALUATION
Tauopathies refer to neurodegenerative disorders characterized by the presence of abnormal aggregates of Tau protein, leading to the formation of neurofibrillary tangles (NFTs) within neuronal cells. Tau, a protein associated with microtubules (MTs), plays a crucial role in regulating the dynamics …
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Targeting Tau Aggregation for the Diagnosis and Treatment of Alzheimer’s Disease
The aggregation of tau protein in the brain is a defining pathological characteristic of several diseases, known as tauopathies, the most common of which is Alzheimer’s disease. Because the temporal and spatial progression of tau lesions correlates with neurodegeneration and cognitive decline, they …
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The role of the type-I interferon response in the aggregation of tau protein
Alzheimer’s disease (AD) and other tauopathies are neurodegenerative diseases characterised by the abnormal intracellular inclusions of hyperphosphorylated tau protein in neurons and/or glia. In AD, tau protein aggregation is accompanied by extracellular plaques of β-amyloid (Aβ) protein, protein …
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Amyloid seeding assays for the selective amplification of tau aggregates from human brain homogenates
The microtubule-stabilising protein tau misfolds and accumulates into amyloid inclusions in a diverse class of diseases called tauopathies. A growing body of biochemical and structural literature has now confirmed that tau takes different disease-specific aggregate conformations, which then …