Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"tau phosphorylation"”.
-
ROLE OF PINCH IN ABERRANT TAU PHOSPHORYLATION IN HIV CNS DISEASE
… aberrant proteins, such as hyperphosphorylated Tau (hpTau). In this context, we have discovered a new signaling connection between age-related neurodegeneration and HIV involving the PINCH protein. Particularly interesting new cysteine histidine-rich protein (PINCH), an adaptor protein in …
-
Fas-associated factor 1 is involved in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice
… disease 3 D. Normal functions of tau protein 4 E. Structure and Posttranslational Modifications of the Tau Protein 5 F. Distribution of tau phosphorylation sites and NFT formation in AD brains 7 G. Monoclonal antibody AT8 recognizes tau phosphorylation 11 H. Cholinergic dysfunction …
-
Using Drosophila to study the contribution of human kinases to tau toxicity
… major neuropathological feature associated with tauopathies is the aggregation of the microtubule associated protein tau within neurons. Aberrant phosphorylation events on tau contribute to the aggregation during disease. The kinases and the phosphorylation sites on tau responsible for the …
-
Studying Models of the Amyloid Cascade Hypothesis Using Single-Molecule Imaging
… to neuroinflammation, oxidative stress, and tau phosphorylation. However, their small size and low abundance makes it challenging to study the soluble Aβ aggregates. Our group has been developing single-molecule and super- resolution microscopy techniques to characterise these aggregates. …
-
Gamma frequency entrainment attenuates amyloid load and modifies microglia
… Finally, we showed that 40 Hz activity reduced tau phosphorylation in the TauP301S mouse model. Overall, our findings uncover a previously unappreciated function of the brain's gamma rhythms in neuroprotection by recruiting both neuronal and glial responses to mitigate AD-associated pathology.
-
The functional role of the retromer complex in the pathogenesis of Alzheimer's disease in Down syndrome
… with DS develop amyloid beta (Aβ) plaques and tau neurofibrillary tangles, the pathological hallmarks of Alzheimer’s disease (AD). This increased susceptibility to Alzheimer’s Disease in Down syndrome (AD-DS) has primarily been attributed to an over-dosage of the amyloid precursor protein …
-
The Genetic Basis Of Neurodegenerative Diseases: The Role Of Sel1L In Tau Pathology And Neuropathology
… elevated levels of phosphorylated microtubule tau protein (p-tau), a pathological characteristic of many neurodegenerative diseases. Our data suggest that a brachial downstream gene of UPR, c-Jun N-terminal kinases (JNK), might be the major tau kinase that induces tau phosphorylation in …
-
The Prostaglandin E2 Receptor Subtype 3E and its involvement in tauopathies
… to the pathogenesis of Alzheimer’s disease and tauopthies. Epidemiological studies report a delay in the onset of Alzheimer’s in subjects using nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit enzymes in the cyclooxygenase-2 (COX-2) pathway which play a key role in synthesising …
-
Protein Misfolding and Aggregation in Neurodegeneration: In Vitro And In Vivo Study Cases
… of my thesis work was focused on Amyloid and tau protein accumulation in 3xTg-AD mice. In order to study neuropathology and cognitive deficits in (AD), several transgenic models of AD have been identified. Accumulation of Abeta and fibrillary tangles as well as impairments in working and …
-
Investigation of the physiological function of TTBK2 (tau tubulin kinase 2), a protein kinase mutated in spinocerebellar ataxia type 11 (SCA11)
… phosphorylate microtubule-associated proteins (tau, tubulin, MAP2) in vitro (Takahashi et al., 1995, Tomizawa et al., 2001). Since this discovery by Japanese scientists in 1995, considerable work has been invested in examining TTBK2’s relationship with aberrant tau phosphorylation and …
-
The role of Substance P in chronic traumatic encephalopathy
… a very unique pattern of hyperphosphorylated tau deposition post-mortem, with accumulation located at the base of the cortical sulci. To date, the link between exposure to rmTBI and the development of both dementia-like symptoms and post-mortem pathology associated with CTE has not been …
-
The Association Between Traumatic Brain Injury and Alzheimer's Disease: Mouse Models and Potential Mechanisms
… tangles: NFTs) composed of hyperphosphorylated tau proteins. Aβ is thought to act upstream of tau, affecting its phosphorylation and therefore aggregation state. One of the major risk factors for AD is traumatic brain injury: TBI). Acute intra-axonal Aβ and diffuse extracellular plaques occur in …
-
Akt signal transduction dysfunction in the 3xTg-AD mouse model of Alzheimer's disease
… filaments (PHFs) of the hyperphosphorylated tau protein, along with synaptic loss and neuronal death. There are numerous biochemical mechanisms involved in AD pathogenesis, however the reigning hypothesis points to toxic oligomeric Aβ species as the primary causative factor in a cascade of …