Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"taste receptors"”.
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Genetic Analysis of Taste in Homo Sapiens
There are many known taste receptors specific to each taste attribute. This thesis examines the relationship between single nucleotide polymorphisms (SNPs) and copy number variations (CNVs) in known taste and taste pathway receptors TAS2R38, Gustin, and TRPM5 and for PROP (6-n-propylthiouracil) …
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Evolution of the Gr family of gustatory and odorant receptors in mosquitoes
… evolutionary boundaries typically revolve around taste and smell. Of the receptors involved in chemoperception, the gustatory receptor (Gr) protein family comprises most of the diversity in the insect chemoreceptor superfamily, including within it not only taste receptors, but select olfactory …
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Study on the effects of bitter taste receptor on the rat pulmonary artery
Bitter taste receptors (TAS2Rs) have been implicated in roles other than taste perception. TAS2R agonists exert vasorelaxant effects in vascular smooth muscle from guinea pig, mouse and humans. We hypothesis that bitter taste agonists could modulate the pulmonary artery vascular tone. The …
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Elucidation of the epithelial sodium channel as a salt taste receptor candidate and search for novel salt taste receptor candidates
Salty taste has evolved to maintain electrolyte homeostasis, serving as a detector for salt containing food. In rodents, salty taste involves at least two transduction mechanisms. One is sensitive to the drug amiloride and specific for Na+, involving epithelial sodium channel (ENaC). A second …
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Formation of Copper-Salivary Component Complexes and Its Effect on Sensory Perception
… a persisting bitter, metallic, or astringent taste. Characteristics and perception mechanisms of copper sensation have not been fully understood. Saliva is assumed to influence copper sensations via binding of salivary electrolytes or proteins with copper. The interaction between salivary …
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Electrophysiological and morphological analyses in two species of insects, Protophormia terraenovae and Ceratitis capitata
… insects present clearly separate senses of taste and olfaction comparable to those of vertebrates, and they represent an excellent experimental model to investigate the complexity of gustative and olfactory systems also thanks to the relative simple organization of their neuronal circuits, …
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Evaluation of sweet taste perception in habitual and non-habitual consumers of low-calorie sweeteners
… by LCS-related changes in the signaling of sweet taste receptors (STRs) located in both the oral cavity and throughout the GI tract. The stimulation of these STRs can impact the rate of glucose absorption in the intestine and the release of insulin and GLP-1 to help regulate glucose and satiety. …
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Butyrate-induced upregulation of intestinal glucose transport and signaling pathways represent a possible nutrient therapy for individuals with malabsorptive disorders
… proglucagon mRNA, and the G-protein coupled receptors (GPCR), Free Fatty Acid Receptor FFAR2) and Free Fatty Acid Receptor 3 (FFAR3), were measured. To establish that butyrate increased the glucose transport capacity of the intestine through upregulation of GLUT2, mRNA abundance and promoter …
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Mosquito Odorant Receptors: C-terminal Motifs, Subfamily Expansion, and Function
… signaling components such as mosquito odorant receptors. This hypothesis is supported by several lines of evidence including the highly divergent and lineage-specific nature of this receptor family. Likely these differences are subtle and will be identified in highly focused studies. Even …
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Neuroanatomical Maps and Taste Reactivity to Sweet, Umami, and Bitter Taste in the PBN of C57BL/6J Mice
… Humans can distinguish at least five different taste qualities, sour, salty, bitter, sweet, and umami (the savory taste of certain amino acids). In neuroscience research, behavioral testing is used to measure the ability of rodents (including inbred mice) to discriminate between the different …
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Erzeugung und Charakterisierung von Mausmodellen mit lichtsensitivem Geschmackssystem zur Aufklärung der neuronalen Geschmackskodierung
… Sinneseindrücke wie Schmecken, Riechen und Tasten. Diese Komplexität der gustatorischen Wahrnehmung erschwert die Beantwortung der Frage wie Geschmacksinformationen vom Mund ins Gehirn weitergeleitet, prozessiert und kodiert werden. Die Analysen zur neuronalen Prozessierung von …
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Sensitivity to chemical stimuli plays a fundamental role in the food preferences. Examples in the evolutionary scale: 1. Role of the walking leg chemoreceptors in the red swamp crayfish Procambarus Clarkii 2. PROP bitter taste sensitivity and its nutritional implications in Humans
… chemical cues occurs by way of peripheral chemoreceptors grouped within sensory hairs and typically located on the cuticle of cephalothoracic appendages. Antennules and pereopods (walking legs), in particular, have been reported to be olfactory organs involved in a number of behavioral …
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ETHNOBOTANICAL SURVEY IN VALMALENCO (SONDRIO, ITALY): STUDY AND ENHANCEMENT OF THE PLANT AND CULTURAL BIODIVERSITY
… the investigation on the preparation’s bitter taste, described by local people as responsible for the traditional therapeutic effect. Thus, preliminary evaluations concerning the interaction of the identified bioactive compounds with bitter taste receptors (TAS2R46) were evaluated through …
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Intracellular pH, the Proximate Signal for Cell Volume Changes that are Mediated by the Actin Cytoskeleton
… with fluorescence imaging in polarized fungiform taste receptor cells (TRCs) loaded with BCECF in vitro. Ammonium pulses caused a brief, reversible alkalinization in pHi and induced cell swelling. Sodium-acetate pulses reversible decreased TRC pHi and induced cell shrinkage. Removal weak acids and …
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Bittergeschmacksrezeptoren des peripheren und zentralen Nervensystems
Der Bittergeschmack warnt den Organismus vor potentiell verdorbener oder giftiger Nahrung und ist somit ein wichtiger Kontrollmechanismus. Die initiale Detektion der zahlreich vorkommenden Bitterstoffe erfolgt bei der Maus durch 35 Bitterrezeptoren (Tas2rs), die sich im Zungengewebe befinden. Die …
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Conformational engineering of human chemokine receptors and HIV-1 Env using deep mutational scanning
… deep mutational scanning to the human chemokine receptors CXCR4 and CCR5, which are well-studied co-receptors for HIV-1 infection. Libraries of both receptors containing nearly all ~7,000 single amino acid substitutions were selected in tissue culture for surface expression, binding to …