Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"taste receptor"”.
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Elucidation of the epithelial sodium channel as a salt taste receptor candidate and search for novel salt taste receptor candidates
Salty taste has evolved to maintain electrolyte homeostasis, serving as a detector for salt containing food. In rodents, salty taste involves at least two transduction mechanisms. One is sensitive to the drug amiloride and specific for Na+, involving epithelial sodium channel (ENaC). A second …
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Rapid Expansion and Specialization of the Bitter Taste Receptor Family in Amphibians
… with a family of intronless G protein-coupled receptors called TAS2Rs. TAS2Rs are well studied in the human and mouse mouth, but recent studies have explored additional species and reported extra-oral expression of a subset of receptors. Here, we systematically search 680 vertebrate genomes, …
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Study on the effects of bitter taste receptor on the rat pulmonary artery
Bitter taste receptors (TAS2Rs) have been implicated in roles other than taste perception. TAS2R agonists exert vasorelaxant effects in vascular smooth muscle from guinea pig, mouse and humans. We hypothesis that bitter taste agonists could modulate the pulmonary artery vascular tone. The …
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Optogenetic examination of salt taste in mice
… designed to evaluate the hypothesis that Type I taste receptor cells play a critical role in the detection and transduction of sodium taste via of epithelial sodium channels (ENaCs). Experiment 1 validated the function of a simple and affordable behavioral apparatus (hardware and software) for …
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Effect of Genetic Variation on Salt, Sweet, Fat and Bitter Taste
Background: Taste is one of the primary determinants of food intake and taste function can be influenced by a number of factors including genetics. However, little is known about the relationship between genetic variation, taste function, food preference and intake. Objective: To examine the effect …
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The Physiological Role of Serotonergic Transmission in Adult Rat Taste Buds
… of the neurotransmitter serotonin (5-HT) in the taste bud is not well understood. Serotonin was long thought to be the neurotransmitter of taste signals from taste receptor cells (TRCs) to the gustatory afferent nerves, but the surprising discovery that this transmission is actually purinergic …
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Intracellular pH, the Proximate Signal for Cell Volume Changes that are Mediated by the Actin Cytoskeleton
… with fluorescence imaging in polarized fungiform taste receptor cells (TRCs) loaded with BCECF in vitro. Ammonium pulses caused a brief, reversible alkalinization in pHi and induced cell swelling. Sodium-acetate pulses reversible decreased TRC pHi and induced cell shrinkage. Removal weak acids and …
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Butyrate-Induced Expression of Proglucagon: Implications for Enteroendocrine Signaling and Intestinal Growth
… suggested that butyrate may be interacting with receptors or transporters to stimulate its effects. To examine this, we silenced the SCFA receptor GPR43 and the bitter taste receptor T2R38 and revealed that butyrate no longer had the capacity to stimulate increased proglucagon abundance. …
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Butyrate-induced expression of proglucagon: implications for enteroendocrine signaling and intestinal growth
… suggested that butyrate may be interacting with receptors or transporters to stimulate its effects. To examine this, we silenced the SCFA receptor GPR43 and the bitter taste receptor T2R38 and revealed that butyrate no longer had the capacity to stimulate increased proglucagon abundance. …
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Neuroanatomical Maps and Taste Reactivity to Sweet, Umami, and Bitter Taste in the PBN of C57BL/6J Mice
… Humans can distinguish at least five different taste qualities, sour, salty, bitter, sweet, and umami (the savory taste of certain amino acids). In neuroscience research, behavioral testing is used to measure the ability of rodents (including inbred mice) to discriminate between the different …
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Die Rolle der Umamirezeptoruntereinheit Tas1r1 jenseits ihrer gustatorischen Bedeutung
Aminosäuren sind lebensnotwendige Moleküle für alle Organismen. Ihre Erkennung im Körper ermöglicht eine bedarfsgerechte Regulation ihrer Aufnahme und ihrer Verwertung. Welcher Chemosensor für diese Erkennung jedoch hauptverantwortlich ist, ist bisher unklar. In der vorliegenden Arbeit wurde die …
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Aktivierung des humanen Süßgeschmacksrezeptors im zellbasierten Testsystem
Zellbasierte heterologe Expressionssysteme bieten ein einfaches und schnelles Verfahren, um neue Süßstoffe oder Süßverstärker zu finden. Unter Verwendung eines solchen Testsystems, konnte ich in Zusammenarbeit mit der Symrise AG, Holzminden und dem Institut für Pflanzenbiochemie in Halle/Saale die …
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Dietary carbohydrates influence the structure and function of the intestinal alpha-glucosidases
… its digestive property. Study on the sweet taste receptor subunits (T1R2 and T1R3) by qRT-PCR showed that the expression of T1R2 and T1R3 increased in presence of maltose compared to glucose. It appeared also that maltooligosaccharides may signal other events in small intestine enterocytes. …
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Herstellung und Charakterisierung von Antikörpern gegen die Geschmacksrezeptoren T1R1 und T1R2
Gustducin ist ein G-Protein, das bei der Geschmackswahrnehmung von "süss" und "bitter" eine Rolle spielt. Es wurde auch im Magen-Darm-Trakt entdeckt. Die Geschmacksrezeptoren T1R1 und T1R2 sind zu 10-20% mit Gustducin auf der Zunge coexprimiert. Kommen auch sie im Magen-Darm-Trakt vor ?
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Immortalisation, characterisation and differentiation of temperature sensitive cell lines from the Olfactory Neuroepithelium
… only one or a few of the many olfactory receptors that are encoded by the large array of olfactory genes. Despite this limited cellular display of receptors, vertebrates are able to distinguish many thousands of different odorants, implying a complicated need for perceptive neurological …
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Electrophysiological and morphological analyses in two species of insects, Protophormia terraenovae and Ceratitis capitata
… insects present clearly separate senses of taste and olfaction comparable to those of vertebrates, and they represent an excellent experimental model to investigate the complexity of gustative and olfactory systems also thanks to the relative simple organization of their neuronal circuits, …
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An Interface of the Taste and Reward Systems in the Brainstem and Its Role in Feeding
<p>We eat what tastes good. We also eat because it is necessary for our health. In fact, some of the most nutritious foods (e.g., vegetables) are often less appetizing, and the tastiest (e.g., fast food, ice cream) may be the least healthy. Despite the former, we may also have a lower limit of what …
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Identifizierung und Charakterisierung von Bitterrezeptoren
Menschen nehmen Tausende von Stoffen als bitter wahr. Die chemische Struktur der verschiedenen Bitterstoffe ist sehr vielfältig: Sie reicht von kleinen Molekülen wie Kaliumchlorid oder Harnstoff, bis zu sehr komplexen organischen Verbindungen. Die Größe der einzigen bekannten menschlichen Familie …
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Effects of fructan source and degree of polymerization on intestinal barrier function and histomorphology characteristics in obese C57BL/6 mice
Obesity is linked to increased intestinal permeability that may contribute to low grade inflammation. Fructan prebiotics have been demonstrated to increase intestinal resistance and decrease systemic inflammation. The objective of this study was to test the effects of prebiotics on intestinal …