Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 33 for “"targeting strategies"”.
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DEVELOPMENT OF TRAPPING STYLE CASSETTES FOR NEW GENE TARGETING STRATEGIES
… Later in the 1990s, innovative gene trapping strategies were developed to enabled random mutagenesis. Today, the goal is to generate more versatile tools to avoid limitations posed by these earlier mutagenesis strategies. Many public and private research centers have united with the aim of …
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Application of Volatility Targeting Strategies within a Black-Scholes Framework
… looks at algorithmically generating a Volatility Targeting Strategy (VTS) which can be used as an underlying asset. The rationale here is that since the VTS has a constant prespecified level of volatility, its returns should be normally distributed, thus tending closer to an underlying that …
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Investigation of Cell-wall Targeting Strategies to Combat Antibiotic Resistance in Staphylococcus Aureus
… in antibiotic resistance and show the promise of targeting the physiology and regulatory mechanisms of bacteria. This work offers a platform for developing new treatments based on adjuvants that will restore the efficacy of existing antibiotics.
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Determinants of facility level environmental inspections
… efficiency of resource allocation by employing targeting strategies. This thesis investigates the scheduling of Clean Water Act inspections in Illinois and the extent to which these inspections are memoryless. Using facility level and local EPA agency level data, we test inspection strategies …
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Laser treatment of hemangiomas using spectroscopic feedback : the "smart scalpel"
… and preliminary verification of the imaging and targeting strategies.
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Fibroblast Heterogeneity In Pancreatic Cancer Immunity
… adenocarcinoma (PDAC). However, general stromal targeting strategies have largely failed in the clinic likely due to the heterogeneity of CAFs in the TME. Therefore, our groups and others have worked to unravel the heterogeneity of CAFs in PDAC. In the works presented herein, we seek to identify …
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Targeting The Blood-Brain Barrier With A Non-Canonical Iron-Mimicry Mechanism
… and allow for the development of ligand-directed targeting strategies of the brain. Here we show the identification of a peptide mediating systemic targeting to the normal brain and to an orthotopic human glioma model. We demonstrate that this peptide functionally mimics iron through an allosteric …
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No Winning Moves: Calculated Casualties and Damages of a Nuclear Attack on the United States by Russia for First and Second Strike Scenarios
… in order to inform policies and negotiations. Targeting strategies were developed for Russian first strike, Russian second strike with strategic warning, and Russian second strike without strategic warning scenarios utilizing the full Russian arsenal for the first strike and only the arsenal …
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Dissecting the Relationship between Mucin 5AC and the Lung/Gut Microbiome in the Pathogenesis of K-ras Mutant Lung Cancer
… Thus, there is a need to develop alternate targeting strategies and test combination therapies for improved intervention. Previously, we have found that KRAS-mutant LUAD (KM-LUAD) patients whose tumors harbor high expression of Mucin 5 AC (MUC5AC), a main airway secretory mucin, have a poor …
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Mechanistic Characterization of RTK Signaling Networks Using Phosphoproteomic Approaches
… a predictive model that can inform future targeting strategies in disease. Here, I present an overview of the value phosphoproteomics adds to cancer research, and the insights we can gain when combined with Y-to-F mutational approaches to gain mechanistic understanding underlying protein …
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Personalized Multimodal MRI-Guided Theta Burst Brain Stimulation for Effective Memory Enhancement in Mild Cognitive Impairment
… Stimulation (TMS) in enhancing intervention strategies for mild cognitive impairment (MCI). The research begins by exploring the foundations of TMS and its potential to alter disease progression through neuroplastic mechanisms. It highlights how advancements in neuroimaging significantly …
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Glucosensing, Hypoglycemia, and the Brain
… will aid in the development of treatment strategies to protect against the pathogenesis of diabetes. In addition, the brain regulates hypoglycemic counterregulation. Hypoglycemia is a major limitation to the treatment of diabetes. Severe hypoglycemia can lead to brain damage, cognitive …
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Nutrient-dependent effects of the autophagy-lysosomal inhibitor, Chloroquine, on cell death and lysosomal functionality
There is huge potential for targeting pro-survival autophagy as a cancer therapeutic strategy, but this approach has not yet been fully realised due to the complex involvement of autophagy for cancer biology. In early stages of transformation, autophagy acts as a tumour suppressor, whilst in a …
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An Analysis of a Public Health Media Campaign in Switzerland
… media channels and ecology, message content, and targeting strategies. Competing theories explain media effects on health behaviours but there is a dearth of research examining upstream planning and stakeholder perceptions of media campaigns. In effect, interactions between communities, health …
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Promoting student retention in two FE colleges
… question of this thesis is: How effective are strategies aimed at promoting student retention in Further Education (FE) colleagues? Non-completion is typically the result of combinations of risk factors, including demographic characteristics, financial constraints, students’ motivation, type of …
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Driving equitable demand : early lessons from the BetterBuildings Program to access 'hard-to-reach' communities for energy efficiency building improvements
… reduce energy consumption in the United States. Strategies to access these 'hard to reach' households, however, are not well understood. The federal Department of Energy's $486 million BetterBuildings program funds 34 grantees to transform regional energy efficiency markets while accessing …
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Modelling resting-state neural oscillations to uncover circuit mechanisms of aging and rTMS response in late-life depression
… potential for optimizing neuromodulation strategies and personalizing clinical care. In the first study, we investigated four neural population models (Jansen-Rit (JR), Moran-David-Friston (MDF), Liley-Wright (LW), and Robinson-Rennie-Wright (RRW)) representing the alpha rhythm within …
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Broad-spectrum antivirals against coronavirus using natural products and drug repurposing strategies
… antiviral profiles. Chapter five shifts to host-targeting strategies through the repurposing of PROTACs (Proteolysis-Targeting Chimeras). Originally developed for oncology, these bifunctional molecules were assessed for their ability to degrade key host proteins exploited by coronaviruses during …
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Design and synthesis of benzosuberene and tetracyclic-based molecules inspired by natural products as inhibitors of tubulin polymerization and preparation of drug-linker constructs to facilitate tumor selective targeted delivery.
… of tubulin polymerization and development of targeting strategies that facilitate selective delivery of therapeutic agents to tumors and the tumor microenvironment. The tubulin-microtubule protein has been established as a prime target for anti-cancer agents specifically with inhibitors of …
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Determining therapeutically actionable genetic interactions in human cancer at scale using multiplexed CRISPR screening
… in precision oncology, enabling the selective targeting of gene loss in cancer. This study employed a high-throughput multiplexed combinatorial CRISPR/Cas9 pooled screening approach to systematically identify SL interactions. A novel tRNA-based dual guide expression system was used to construct …
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