Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 62 for “"targeted therapeutics"”.
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Phosphonium-functionalised gold nanoparticles for mitochondria targeted therapeutics.
The work presented in this thesis demonstrates that triarylphosphoniopropyl-thiosulfate zwitterions and w-thioacetylpropyl(triphenyl)phosphonium salts can be used to prepare cationic, water-soluble gold nanoparticles with mean core sizes in the range of 2.5-5 nm. Phosphonium-functionalised gold …
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Arsonium and phosphonium-functionalized gold nanoparticles for mitochondria targeted therapeutics
This thesis presents a body of original research describing the synthesis, characterisation and biological properties of novel arsonium- and phosphonium- alkylthiosulfate zwitterions and thioacetate salts and gold nanoparticles functionalized with triphenylarsoniumpropylthiolate ligands. Chapter 1 …
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De novo designed protein switches to enable increased specificity of targeted therapeutics
Targeted immunotherapies typically rely on the recognition of a single cell-surface marker, and as such, their specificity is limited and prone to incidentally harming healthy cells. This is problematic for developing treatments for solid tumors where ‘tumor-specific’ antigens are also expressed on …
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Development of chemical tools for biomarker detection and targeted therapeutics for precision medicine
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Fulfilling the promise of targeted therapeutics in oncology via companion diagnostics : a perspective on pipeline trends and co-development strategies
… a testament to the fact that the age of cancer therapeutics co-developed with a companion diagnostic is finally upon us. The purpose of this thesis was to test the hypotheses, that the trend for CDx based therapy launches in oncology is NOT headed towards a dramatic upturn in the next 5 years …
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Molecular Mechanisms for the Angiotensin-(1-7)-Mediated Inhibition of Metastatic Triple Negative Breast Cancer
… levels, contributing to an absence of effective, targeted therapeutics. Furthermore, triple negative breast cancer (TNBC) is highly-aggressive with greater patient mortality rates compared with other breast cancer subtypes, necessitating development of novel treatment options.
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Microelectrode Array Modeling of Genetic Neurological Disorders in the Era of Next Generation Sequencing
… mechanisms is crucial to the development of targeted therapeutics. Therefore, the main challenge to translating genetic findings into targeted therapeutics is functional modeling.</p><p>Increased understanding of the genetic architecture of epilepsy and the hyperexcitability that results from …
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Drug design strategies for modulating immune activity for the treatment of autoimmune diseases and cancer
… properties of various immune-modifying therapeutics to improve their delivery to their intended biological destination. In chapter 2, we used a small molecule inhibitor of N-linked glycosylation, kifunensine, to demonstrate the role of glycosylation in affecting B-cell receptor …
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DEVELOPMENT OF VIRTUAL SCREENING METHODOLOGIES FOR IDENTIFYING RNA-BASED THERAPIES
… interactions, supporting the development of RNA-targeted therapeutics and enhancing the field of computational structural biology.
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AGO2 in overexpression exhibits oncogenic functions KrasG̳1̳2̳D̳ -associated mouse tumor models
… progression is imperative in the development of targeted therapeutics. This thesis focuses on the role of Argonaute-2 in promoting cellular transformation in mouse model systems, highlighting novel oncogenic functions associated with AGO2 overexpression. In short, we have determined that AGO2 …
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Sub-Picomolar Detection of SARS-CoV-2 RBD via Computationally-Optimized Peptide Beacons
… global health threat. Along with vaccines and targeted therapeutics, there is a critical need for rapid diagnostic solutions. In this work, we employ a deep learning-based protein design to engineer molecular beacons that function as conformational switches for high sensitivity detection of the …
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4D Ex Vivo Crispr/Cas9 Whole-Genome Screen to Identify Genes Regulating Lung Cancer Metastasis
… for the development of early diagnostics and targeted therapeutics.<strong> </strong>We performed a proof-of-concept CRISPR/Cas9 whole genome knockout screen in the A549 lung adenocarcinoma cell line and utilized a novel <em>ex vivo 4D </em>lung metastasis model to find gene candidates to test …
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A Stem Cell-Based Strategy for Modeling Human Kidney Disease and Discovering Novel Therapeutics
… millions of people worldwide and there are no targeted therapeutics. Given the global burden and increasing prevalence of CKD, the kidneys represent an attractive target for regenerative medicine. The most severe forms of CKD involve irreversible damage to kidney glomerular podocytes - the …
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DESIGNING A PLATFORM FOR DEVELOPING NOVEL GLYCAN-BINDING PROTEINS USING YEAST SURFACE DISPLAY
… makes them important targets for the design of therapeutics and diagnostics. However, a major limitation in targeting the vast array of glycans has been the lack of reliable reagents. Many existing glycan-binding proteins exhibit broad specificity, low affinity, and are costly to produce. Thus, …
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Protein engineering for targeted delivery of radionuclides to tumors
… surgery only target known cancer sites. However, targeted therapeutics, such as antibodies, will bind to all cancer cells that express the targeted antigen, including small metastases that are invisible by current imaging technology. In the past decade, nine antibodies have been approved for the …
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Sex Differences in Collateral Remodeling Following Hindlimb Arterial Occlusion
… differences could be the foundation for which targeted therapeutics are developed, which will be crucial for closing the prognosis gap between men and women in the global treatment of peripheral arterial occlusive disease.</p>
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Engineering Hv1 Channel Mutations and Targeted Drug for Treatment of Hv1 Mutation Associated with Cancer
… whether these mutations can be therapeutically targeted is still unclear. This project aims to investigate the functional impact of Hv1 disease mutations and develop targeted therapeutic strategies. The research is structured into three specific aims including engineering Hv1 mutations, …
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Leveraging cellular models of polycystic kidney disease for mechanistic discovery and therapeutic development
… mechanisms and supports further development of targeted therapeutics.
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Combinatorial Roles Of Skeletal Cell Yap And Taz In Bone Growth, Remodeling, And Repair
… repair is important to the future development of targeted therapeutics. The functions of the paralogous transcriptional co-activators Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) in bone are controversial, with evidence for each either promoting or …
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