Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"targeted mass spectrometry"”.
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The Development and Application of Non- Targeted Mass Spectrometry Based Methods to Tea (Camellia Sinensis L.)
Non-targeted analysis is an analytical approach which attempts to measure changes in the abundance of as many metabolites as possible (both known and unknown) in a single sample. Methodologies to perform this demanding task require regular improvement to keep pace with on-going technological …
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Using non-targeted mass spectrometry to identify proteomic, metabolomic and lipidomic profiles in saliva to compare the impact of prolonged vs. interrupted sitting
… sedentary physiology research focuses on targeted approaches. To explore from a new perspective, a non-targeted approach with the use of Liquid Chromatography-Mass Spectrometry (LC-MS) to assess the responsiveness of proteins and metabolites in saliva to sedentarism was employed. The study …
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Regulation of Diacylglycerol Acyltransferase-2 and Triacylglycerol Synthesis by Protein Ubiquitination
… We determined that DGAT2, MGAT2 and MGAT3 are targeted for endoplasmic-reticulum-associated degradation (ERAD), as ERAD inhibition caused poly-ubiquitinated species of all three proteins to accumulate. Moreover, overexpression of DGAT2 and MGAT2 resulted in redistribution of the ERAD ATPase, …
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Isolation and characterisation of novel DNA aptamers against Mycobacterium tuberculosis biomarkers: new tools for tuberculosis diagnostics
… urine which was identified by western blot and mass spectrometry. Targeted mass spectrometry did not detect ESAT-6 or its dimer partner, culture filtrate protein-10 kDa (CFP-10) in tuberculosis positive patient urine. Since concentrating urine samples is impractical in a clinical setting a more …
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Application and integration of bioinformatic strategies towards central and peripheral proteomic profiling for diagnosis and drug discovery in schizophrenia
… as measured through multiplex immunoassay or targeted mass spectrometry technologies. In chapter 4, an SVM model based on 21 peptides was identified that is both highly sensitive and specific as a diagnostic and prognostic tool in symptomatic individuals. Furthermore, in recent years, few …
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Analysis of urinary lipid biomarker candidates from tuberculosis patients by multiple reaction monitoring
… biofluid for biomarker investigation. Full scan mass spectrometry is the gold standard for the unbiased discovery of biomarker candidates, and targeted multiple reaction monitoring (MRM) is the method of choice for subsequent validation of biomarker candidates. A list of candidate urinary …
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Development and validation of blood-based proteomic biomarker-sociodemographic diagnostic prediction models to identify major depressive disorder among symptomatic individuals
… sociodemographic and lifestyle factors. A targeted mass spectrometry approach was used to measure the abundances of a panel of peptides representing proteins, many of which have been previously associated with psychiatric disorders. Biomarkers were investigated in serum samples, which are …
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StCKP and potato tuber dormancy
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