Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"targeted gene delivery"”.
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ENGINEERING LIPID AND HYBRID NANOVECTORS FOR TARGETED GENE DELIVERY TO MACROPHAGE SUBPOPULATIONS
… the possible architectures that can arise when genetic materials are complexed with a polycation or a lipid, followed by the addition of a lipid or a polymer to ameliorate the cellular toxicity, modulate cellular uptake and/or improve the transfection efficiency of the resulting nanovectors …
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Development of targeted gene delivery vectors to assess cardiac overexpresion of ACE2 in vivo
… for new therapies to treat these conditions. Gene therapy for the treatment of cardiovascular diseases is currently being developed. Gene therapy is by definition the treatment or prevention of disease by means of gene transfer. The efficiency of gene transfer will determine how successful the …
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Metabolic biotinylation of the adenoviral capsid: Avidin-based applications and studies of ligand-targeted gene delivery
… vectors have great potential for use in gene therapy and genetic immunization. The targeting of Ad vectors to the relevant tissue and cell types in vivo could greatly improve their safety and performance by lowering the effective dosage required for therapeutic levels of gene expression. …
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MODIFICATION OF VESICULAR STOMATITIS VIRUS G PROTEIN FOR TARGETED GENE DELIVERY INTO PSCA-POSITIVE TUMOR CELLS
Gene therapy is a promising treatment option for cancer. Ideally, a therapeutic gene is delivered specifically into tumor cells sparing the neighboring normal cells. For this purpose gene delivery vectors are designed that can recognize structures, which are exclusively expressed on tumor cells …
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Molecular-thermodynamic theories of micellization of multicomponent surfactant mixtures and of pH-sensitive surfactants
… including controlled drug release, targeted gene delivery, and the fabrication of nanoscale materials for optics, electronics, and sensors. First, a molecular-thermodynamic (MT) theory was developed to account for counterion binding to mixed micelles composed of ionic-nonionic and …
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Expanding the toolkit of protease activatable viruses to improve their versatility and modularity
… virus (AAV) has emerged as a promising gene delivery vector because of its non-pathogenicity, simple structure and genome, and low immunogenicity compared to other viral vectors. However, its adoption as a safe and effective gene therapy treatment for disease relies on targeting the …