Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 116 for “"targeted drug delivery"”.
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Magnetic Targeted Drug Delivery
… guidance system that is needed for an effective drug delivery system. This thesis reviews past magnetic drug delivery work, variables, and concepts that needed to be understood for the development of an in vivo magnetic drug delivery system. The results of this thesis are the concise study and …
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Targeted drug delivery within the eye
… segment of the eye using microneedles as a drug delivery platform. The first part of the work determines the ability to deliver protein therapeutics into the cornea using coated microneedles to suppress corneal neovascularization in a rabbit model. The data show that highly targeted delivery …
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Novel polymeric microcapsules for targeted drug delivery
… investigated how to develop a post-ruminal delivery system based on polymeric microencapsulation. A major criterion was to develop microcapsules with reversible switching in response to changes of pH in the in vivo environment so contents could be released. The microcapsules must have a thin …
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Preparation of nanovehicles for targeted drug delivery
… research has opened new frontiers for drug development and its efficient delivery. In recent years, the focus of the research has been on the engineering of nano/micro-particulate structures for efficient and targeted delivery of drugs for selective and enhanced absorption. This work …
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Capsule-based Ultrasound-mediated Targeted Drug Delivery
… progress in advancing therapeutic CE (TCE). Targeted drug delivery (TDD) is a therapeutic modality that could be combined with CE. It allows drugs to be delivered to the diseased tissue, enhancing effectiveness and reducing side effects. Several proof of concept TCEs for TDD exist (Parr et …
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Magnetic targeted drug delivery system in gene therapy
Drug delivery system is a method to transport the drug of the required amount accurately to the targeted diseased part. Recently, the concept of Magnetic Targeted Drug Delivery System (MTDDS), based upon magnetic particles under the action of an external magnetic field, exhibits considerable …
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Peptide Targeted Drug Delivery to Non-Small Cell Lung Cancer
… targeting therapies that specifically deliver drugs to the tumor, reducing accumulation and toxicity in non-target tissues, are a promising niche of cancer therapeutics, and the H2009.1 peptide is anticipated to have great utility as a targeting ligand for the delivery of therapeutics to …
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A novel method of producing microbubbles for targeted drug delivery.
… have a potential new application as vehicles for targeted drug delivery, which could revolutionise medicine by eliminating side-effects. A new device is developed which outperforms all existing devices in terms of minimum microbubble size:channel diameter ratio. A numerical model is established to …
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Targeted Drug Delivery with Cyclodextrin-based Nanocarriers and Focused Ultrasound Triggering
… solutions to overcome the current challenges of targeted drug delivery (TDD) to tumours using magnetic resonance imaging guided focused ultrasound (MRgFUS) to cavitate microbubbles (MBs) for increasing cell permeability and to open ‘drug nano-capsules’ to release proven active anticancer drugs …
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Ultrasound mediated Targeted Drug Delivery In Vitro: design, evaluation and application
Background Targeted Drug Delivery (TDD) is a therapeutic modality which allows an increase in the medication dose at a treatment site, while simultaneously avoiding effects in the rest of the human body. This can be achieved via different types of delivery vehicles or carriers which encapsulate the …
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Synthesis and Characterization of Redox-Sensitive Polymer and Prodrug for Targeted Drug Delivery
… in off-target sites and acute toxicity of the drugs. In the past decade, engineering targeted drug delivery platforms arose as a novel paradigm to overcome such obstacles and ultimately achieve advanced forms of chemotherapy. This thesis reports successful syntheses of l-RSP, a redox-sensitive …
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Poly(LA-co-TMCC)-graft-PEG Self-assembled Polymeric Nanoparticles for Targeted Drug Delivery
… have gained increased popularity for drug delivery as they not only overcome the problem of limited aqueous solubility of many hydrophobic drug molecules, but also have the potential to improve the pharmacologic properties of anticancer drugs by increasing their in vivo half-life. A …
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Discovery of Peptide and Aptamer Ligands for Targeted Drug Delivery to Hepatic Stellate Cells
… Therefore, development of HSC-specific delivery systems is essential for the success of antifibrotic agents. The objective of this Chapter is to identify peptide ligands targeting the insulin like growth factor II receptor (IGFIIR), which is overexpressed in HSCs during liver …
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Design of functional polymeric materials for cancer-targeted drug delivery and cellular capture and isolation
… for a variety of applications. In the drug delivery field, the use of synthetic polymers as nano-sized drug carriers in cancer nanomedicine has gained tremendous interest as an alternative to conventional small molecule anticancer drugs to reduce drug-related toxicity and increase …
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Development and Evaluation of Paclitaxel-Loaded Liposomal Formulations for Targeted Drug Delivery to Breast Cancer
… paclitaxel-loaded liposomal formulations for targeted drug delivery to breast cancer. The liposomal formulation was optimized to maximize drug loading and physical stability. Cholesterol and saturated lipid content showed a negative influence on paclitaxel loading. Short-term stability studies …
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Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes
… conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow the conjugate to circulate longer in the body by minimizing renal and hepatic …
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Development and evaluation of amphotericin B Loaded iron oxide nanoparticles for targeted drug delivery to systemic fungal infections
<p>A targeted nanotheronostic drug delivery system to diagnose and treat life threatening invasive fungal infections (IFIs) such as cryptococcal meningitis was designed, developed, characterized, and evaluated. To address the development processes, first, iron oxide nanoparticles (IONP) (34-40 nm) …
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Design, Development and Evaluation of Erlotinib-Loaded Hybrid Nanoparticles for Targeted Drug Delivery to NonSmall Cell Lung Cancer
… albumin hybrid nanoparticles (CSLAHNPs) for targeted drug delivery to nonsmall cell lung cancer (NSCLC). Erlotinib (ETB) is a highly selective, potent and reversible inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR) which is overexpressed (50-90%) in NSCLC. ETB is marketed …
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