Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"targeted covalent drugs"”.
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Discovery of covalent modifiers via the complexity to diversity strategy
Targeted covalent drugs have recently become integral parts of drug discovery. Given the advantages of high-throughput screening in drug discovery, many electrophilic fragment collections have been developed as a promising alternative to discover and validate novel targets. However, most covalent …
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Towards targeted post-translational modification of endogenous proteins in complex environments
… can be exploited pharmacologically, as covalent inhibitors such as aspirin covalently bind, or attach a covalent payload, to the active sites of enzymes. Following this principle, rationally designed targeted covalent inhibitors (TCIs) adapt non-covalent ligands to react with …