Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"targeted cancer therapy"”.
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Carbon Monoxide Prodrugs for Targeted Cancer Therapy
… clinical conditions, including inflammation and cancer. However, challenges in targeted and controlled delivery have limited its clinical application, prompting the development of novel CO-releasing prodrugs. This thesis presents the design and development of radical-activated, metal-free …
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Development of polymeric drug delivery vehicles for targeted cancer therapy
… my Ph. D. thesis is to generalize a method for targeted anti-cancer drug delivery. Hydrophilic polymer-drug conjugates involve complicated synthesis; drug-encapsulated polymeric nanoparticles limit the loading capability of payloads. This thesis introduces the concept of nanoconjugates to …
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Fighting cancer with nanomedicine−drug-polyester nanoconjugates for targeted cancer therapy
… reticuloendothelial system (RES) and facilitate targeted cancer diagnosis and therapy. By uniquely integrating well-established chemical reaction-controlled ring opening polymerization (ROP) with nanoprecipitation technique, I successfully developed a polymeric NC system based on poly(lactic …
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GLYCOSAMINOGLYCAN COATED GOLD NANOPARTICLES FOR TARGETED BREAST CANCER THERAPY
Studies have reported that breast cancer has become one of the most common cancers in the world. CD44 is a biomarker that is overexpressed in most types of cancer cells, including breast cancer. Glycosaminoglycans (GAGs), such as hyaluronic acid (HA) and chondroitin sulfate A (CSA), are known as …
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DEVELOPMENT OF NANO-CELL VESICLE TECHNOLOGY SYSEM (nCVTs) FOR CANCER THERAPY
Cancer, a leading cause of death worldwide, despite the enormous amount of effort being invested in finding the cure. This thesis examines the development of a nano-biohybrid system, termed nano-Cell Vesicle Technology System (nCVTs), as a drug delivery system for cancer therapy. Being a hybrid …
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PHOSPHORYLATION OF NF-ΚB RELA/P65 ON SER536 SIGNALS CANCER CELLS TO DEATH AND ENHANCES CHEMOSENSITIVITY
… of NF-kappaB inhibitors have been developed for targeted cancer therapy, but fail to achieve anticipated anticancer efficacy. Complexity of posttranslational modifications may contribute to tumorigenic diversity of RelA/p65, but mechanisms of action remain unclear. Here we show that …
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Detection and enrichment of cytochrome P450s using bespoke affinity chromatography and proteomic techniques. Development of chemical immobilisation and novel affinity chromatography methods, with subsequent proteomic analysis, for the characterisation of cytochrome P450s important in cancer research.
… and excretion. P450s are also implicated in cancer as they can act to ¿negatively¿ de-activate or ¿positively¿ activate cancer therapeutics. Identifying specific P450s that are highly up-regulated at the tumour site could be used to predict drug response and formulate targeted cancer therapy …
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Interaction of Nanoparticles with RF, AC, and Static Magnetic Fields in Thermal and Non-Thermal Cancer Therapy Applications
… science of addressing the complex problem of targeted cancer therapy. Thermal therapies such as radio-frequency and microwave hyperthermia and ablation techniques though effective in ablating tumors are non-target specific. The dissertation focus on alternate thermal and non-thermal approaches …
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Rationally designed aplyronine analogues for use in antibody-drug conjugates
… effects at picomolar concentrations in human cancer cell lines. Through a novel dual protein-targeting mechanism of action, their exquisite potency renders the aplyronines promising drug candidates. However, the scarcity and structural complexity of the aplyronines brings challenges in …
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Single-Payload Bioconjugation to Native Antibodies And A General Method for the Self-Immolative Release of Amide-Containing Molecules
… (ADCs) have emerged as a powerful form of targeted cancer therapy that can deliver drugs with a high level of selectivity towards a specific cell type, reducing off-target effects and increasing the therapeutic window compared to small molecule therapeutics. However, creating ADCs that are …
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Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition
… longer survival and superior quality of life for cancer patients with particular malignancies compared to the preceding standard of care. However, many patients still fail to show a clinically meaningful response to kinase inhibitors prescribed on the basis of tumor genotype, and nearly all …
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Designed Bond Cleavage Reactions for Next-Generation Therapeutics
… by developing novel prodrug systems that enable targeted activation in diseased tissues. The first project focuses on a metal-mediated amide bond-cleavage reaction from a pentenoic group by using Au salt (Na[AuCl4]) for prodrug activation in aqueous systems. Central to this strategy is a …