Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 127 for “"target site"”.
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Non-target-site resistance to ALS inhibitors in waterhemp
… amino acid biosynthesis, and is the target site of five families of herbicides referred to as ALS inhibitors. Waterhemp (Amaranthus tuberculatus) is considered one of the most problematic weeds in the Midwest cropping region. The evolution of herbicide resistance and multiple …
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DNA target site recognition by the Ll.LtrB group II intron RNP
Mobile group II introns are retroelements that site-specifically insert into DNA target sequences. The group II intron mobility pathway is mediated by a ribonucleoprotein particle (RNP) composed of excised intron RNA and an intron-encoded protein (IEP). The intron lariat inserts at a specific DNA …
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Exploring Endoplasmic Reticulum as a Therapeutic Target Site to Antagonize Amyloid Production.
… (AD) pathogenesis. Therapeutic strategies targeting extracellular deposits of Aβ, or inhibiting enzymes releasing Aβ from APP, have not been as successful as first envisioned and motivate alternative approaches, such as reducing the production of Aβ by modifying APP localisation. This …
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Examination of target-site-based mechanisms of glyphosate resistance in waterhemp (Amaranthus tuberculatus)
… resistance to herbicides spanning multiple sites of action. Three potential mechanisms of resistance have been linked with GR waterhemp: EPSPS gene amplification, EPSPS target-site mutations, and reduced translocation. The objective of this research was to investigate the target-site-based …
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STUDIES ON INSECTICIDE RESISTANCE IN TUTA ABSOLUTA (MEYRICK), WITH SPECIAL EMPHASIS ON CHARACTERISATION OF TWO TARGET SITE MECHANISMS
… of any mutations in these two insecticides targets in several laboratory strains. Cloning and sequencing of domains II, III, and IV of the T. absoluta sodium channel gene revealed the presence of several kdr mutations previously reported to confer reduced sensitivity in other arthropod …
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From the simple to the complex: an examination of different herbicide resistances
… as goosegrass (Eleusine indica), frequently have target-site resistance mechanisms controlled by a single gene. Outcrossing species, such as waterhemp (Amaranthus tuberculatus), in addition to having herbicide resistance conferred by a target-site mutation controlled by a single gene, often evolve …
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Recent advances using genetic analyses in waterhemp
… challenges in the species. Recently, non-target-site herbicide resistance has been increasingly associated with new evolutionary events, further limiting the potential for effective herbicide programs to control the weed, leading to a need for new management options. Understanding the …
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Defining Delivery Pathways of Nanoparticles
… to use nanoparticles to carry drugs to specific target site in the body. For cancer nanomedicine, a recent meta-analysis showed that only 0.7% of the injected nanoparticles reach the tumour. To address this delivery inefficiency, it is important to examine each biological barrier to determine its …
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Thermodynamics and kinetics of antisense oligonucleotide hybridization to a structured mRNA target
… These early studies have shown that selection of target site, once considered a trivial problem, is critical to the success of antisense strategies. It has become clear that the efficacy of antisense oligonucleotides is a strong function of the structure of the target mRNA. Though single-stranded, …
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Exploiting muscarinic acetylcholine receptors as an insecticidal target to enhance the toxicity of gamma-amino butyric acid channel blockers and the continued challenges with resistance
… there are no commercialized insecticides targeting insect mAChRs. In this dissertation, effective target-site synergism was demonstrated in susceptible Drosophila melanogaster where mAChR agonism by pilocarpine enhanced the toxicity of insecticides targeting gamma-aminobutyric acid …
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Understanding the Interaction of Mesotrione and Atrazine in Redroot Pigweed (Amaranthus Retroflexus)
… also persists in broadleaf weeds with a target site-based resistance to atrazine, thus, providing a potential reversal of atrazine resistance in these weed biotypes when atrazine is applied in mixture with mesotrione. Furthermore, an increased sensitivity to atrazine was observed in the …
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Toxicological Analysis of Acaricides for Varroa Mite Management
… bee colony health. The mite nervous system is a target site for existing acaricides. These acaricides not only have adverse health effects on bees, but resistance limits their use to reduce mites and diseases in bee colonies. Voltage-gated chloride channels are involved in the maintenance of …
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Toxicological Analysis of Tacrines and Verapamil on the Yellow Fever Mosquito, Aedes aegypti
… blood-brain barrier (BBB) to interfere with the target-site delivery and action of anticholinesterase chemistries. The ATP-binding cassette (ABC) transporters are efflux proteins that assist in maintaining the BBB interface and serve as a first line of defense to mosquitocide exposures. To date, …
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Accurate Target Geolocation and Vision-Based Landing with Application to Search and Engage Missions for Miniature Air Vehicles
… demonstrate the ability to consistently localize targets to within 5 m regardless of wind conditions. The second half of this thesis focuses on using the high accuracy geolocation estimates to complete a search and engage mission. This is a mission in which the MAV not only locates the target, but …
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Single-molecule methods for an improved understanding of biophysical interactions: from fundamental biology to applied nanotechnology
… require proteins to recognize a specific DNA target-site. This search process is well-documented for monomeric proteins, but not as well understood for systems that require dimerization or oligomerization at the target site for activity. We present a single-molecule study of the target-search …
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Immunospecific albumin microspheres as a drug delivery system for cisplatin and 5-fluorouracil for the treatment of ovarian adenocarcinoma
… directly to the malignant cells. This mode of targeted delivery allows for efficient tumour cell kill whilst sparing surrounding normal tissue and substantially reducing side-effects. This project examined the possible therapeutic role of a targetable sustained drug delivery system, albumin …
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The role of chemokine receptor trafficking in regulating neutrophil migration to inflammatory sites
… are the first immune cells to be recruited to sites of tissue injury or infection. Upon detection of an inflammatory stimulus, neutrophils exit the vasculature and migrate directionally through the interstitial tissue towards the target site. Once at the target site, neutrophils may either …
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Determination of total, unbound, and intracellular concentrations of the antiretroviral drugs Efavirenz, Lopinavir, and Ritonavir
… variability in the amount of drug reaching the target site within the HIV-infected cells. Therefore, intracellular drug concentrations could provide a more accurate depiction of drug exposure. An alternative to intracellular drug concentrations could be the quantitation of drug not bound to …
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GENETICS OF GROUP 14 HERBICIDE TOLERANCE IN LENTIL
… growth and development. This suggests that a non-target site resistance mechanism in combination with plant regrowth is the main cause for the observed differences in tolerance. A follow-up study on the importance of cytochrome P450s and glutathione-S-transferase demonstrated that cytochrome P450s …
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Use of estradiol-BSA conjugates to characterize membrane estrogen binding sites in brain cells: Biochemical and physiological studies
… receptor (ER). Specific membrane binding sites for estrogen (mEBS) in female rat brain were demonstrated by a novel and sensitive radioligand binding assay using 17$\beta$-estradiol covalently linked with ($\sp{125}$I) -labeled bovine serum albumin (17$\beta$-E-6- ($\sp{125}$I) BSA …
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