Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 80 for “"target identification"”.
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Vibrotactile Guidance Cues For Target Identification
… palmer versus dorsal surface of the hand, and targets appearing left versus right of center. Results suggest that tactile cues provided on the left side of the medial line of the hand afford moving the hand to the left, while tactile cues provided on the right side of the medial line afford …
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Design of a Microwave Imaging System for Target Identification
… imaging system to reconstruct images of unknown targets. In our system, we primarily use the common Wi-Fi frequencies of 2.4 GHz and 5 GHz because of the wide availability of commercial microwave components that operate at these frequencies. For the image reconstructions of the targets, we used …
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Adaptive Beamforming using ICA for Target Identification in Noisy Environments
The blind source separation problem has received a great deal of attention in previous years. The aim of this problem is to estimate a set of original source signals from a set of linearly mixed signals through any number of signal processing techniques. While many methods exist that attempt to …
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Natural resonance extraction and annihilation filtering methods for radar target identification
… attempt to demonstrate aspect independent target identification of complex radar targets using annihilation filters based on the natural resonances of the targets. The Cadzow-Solomon signal processing algorithm is tested to determine its suitability for the task of extracting the poles from …
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Molecular target identification of antimalarial drugs using proteomic and metabolomic approaches
… has been recognized as a source of therapeutic targets. Targeted metabolite profiling has aided in the understanding of several biological processes in the parasite besides drug discovery. Therefore, having a robust analytical platform to quantify the purines and pyrimidines is of a great value. …
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Target Identification and Mechanism of Action Studies in Folate Metabolism in Kinetoplastids
… exploited in a number of drugs and drug targets. The same cannot be said for the kinetoplastids. Drug discovery programmes have focused on targeting enzymes of the folate metabolism with very little clinical success. Despite showing significant inhibition of the parasitic enzymes, potency …
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Target identification theory for synthetic aperture radar images using physics-based signatures
Thesis (Sc.D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1999.
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Total Synthesis of the Actinoallolides and a Designed Photoaffinity Probe for Target Identification
… studies to identify the in vivo protein binding target(s) of the actinoallolides, shedding light on their mechanism of action and enabling further biological investigation of these highly potent and selective natural products.
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Computational analysis of biochemical networks for drug target identification and therapeutic intervention design
Identification of effective drug targets to intervene, either as single agent therapy or in combination, is a critical question in drug development. As complexity of disease like cancer is revealed, it has become clear that a holistic network approach is needed to identify drug targets that are …
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PASSIVE RADAR TRACK CLUSTERING: HIGHER FIDELITY OF TARGET IDENTIFICATION AND CLASSIFICATION OF UNLABELED TRACKS
Effective radar signal classification is critical for naval electronic warfare systems like the SLQ-32, but data scarcity limits machine learning applications. This research evaluates semi-supervised learning (SSL) techniques to leverage unlabeled data for improved classification. Using a NIST …
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Mechanism of Action Studies of Phenotypic Whole-cell Active Antimalarial Leads Through Target Identification
… represent one of the genomics tools for target deconvolution of hit and lead molecules. The mechanism of resistance of the pyrido[1,2- a]benzimidazoles was investigated through resistance selection. Whole-genome sequencing of the mutant clones generated from KP68 under drug pressure …
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Cellular mechanisms of environmental enrichment: Novel discovery-based strategies for target identification for neuropsychiatric disorders
… Thus, it is critical to determine novel targets for substance use disorders with comorbid mood disorders. In order to identify novel targets, we examine an animal model of the resilience to depression and addiction, environmental enrichment. Environmental enrichment is a non-drug, …
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Diverse roles for the mitogen-activated protein kinase ERK2 revealed by high-throughput target identification
… vemurafenib, the first pharmaceutical directly targeting the MAPK pathway, has recently been approved to treat advanced melanoma. ERK controls cellular phenotypes by phosphorylating over two hundred known substrate proteins, however new ERK targets are reported frequently. We have used a …
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Comprehensive single and paired drug target identification in healthy and disease models of NF-kB pathway
… in the NF-[kappa]B pathway that if inhibited/ targeted by added drugs normalize the levels of NF-[kappa]Bn. Also, since there is a limit to how effective single drug targets are in complicated diseases, identification of combinations of targets is very important. Existing experimental and …
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Computational modeling of knowledge and uncertainty in systems biology for drug target identification and protein engineering
… in immune response, to find promising drug targets for treatment of sepsis. I compared a sampling method to a worst-case search method for quantifying the uncertainty in responses to hypothetical inhibitors and found that the choice of method significantly impacts the results. I identified …
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Development and Application of Large-Scale Protein Folding Stability Analysis in Drug Target Identification and Disease Biomarker Discovery
… protein folding stability approaches in drug target identification and disease biomarker discovery. One goal of this work is to develop a novel chemo-selection strategy to improve the bottom-up proteomics readout in proteome-wide limited proteolysis experiments. Another goal of this work is to …
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Exploring the network’s world: From omics-driven machine learning workflow for drug target identification to quantification of signaling model diversity.
… time-consuming, and costly, with drug target identification being an essential step in developing effective therapies. Drug repurposing offers a strategy for identifying new uses for existing drugs, aiming to simplify the process. Machine learning models and network analysis methods …
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Virtual Environment Creation and Camera Calibration for Soft Target Identification and Assistance in Crowded Spaces with a Sensor Network and a Robotic Dog
… places are increasingly targets of violence due to the increased accessibility and covertness of weapons, explosives, and other technology like drones. Addressing the challenges of protecting crowded places and assisting vulnerable individuals requires a multidisciplinary …
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Subliminal priming as a task-characteristic artifact
… subliminal priming rely on a dual task design: A target identification task in which the priming effect is measured, and a prime identification task in which visibility of the primes is assessed. The validity of this design relies on the critical assumption that the estimates of prime visibility …
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Broadband microwave inverse scattering: Theory and experiment
… probing, medical imaging and military target identification. Emphasis is placed on the use of microwaves to probe the unknown object, although much of the theory presented applies to other types of waves such as acoustic and elastic waves.
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