Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 570 for “"target genes"”.
-
The developmental function of Pax7 : chromatin-immunoprecipitation discovery of Pax7 target genes
… by Pax7 during development is the selection of target genes. To date, an accurate description of the function of this transcription factor has not been obtained through an understanding of its target genes. To elucidate the direct developmental functions of Pax7, this research has sought to …
-
Batf regulates previously unknown AP-1 target genes to control TH17 differentiation
… cells, we generated Batf deficient mice by gene targeting. Batf <super>-/-</super> mice show a highly selective defect in TH17 differentiation. As a result, Batf -/- mice are completely resistant to experimental autoimmune encephalomyelitis. Using gene expression analysis, we found that Batf …
-
New Target Genes For Tumor Suppressors P53 and P73 In Regenerating Liver
… p53-family of proteins regulates expression of target genes during tissue development and differentiation. Within the p53-family, p53 and p73 have hepatic-specific functions in development and tumor suppression. Despite a growing list of p53/p73 target genes, very few of these have been studied …
-
Identification of Novel HIF1A Target Genes That Regulate Tumor Progression and Metastasis
… by regulating survival, metabolism and angiogenesis. The heterodimeric HypoxiaInducible Factor (HIF) transcription factors are the master regulators of this response. HIFs play key roles in many critical aspects of cancer biology including angiogenesis, stem cell maintenance, metabolic …
-
Analysis of target genes of the transcription factor CREM during mouse spermatogenesis
… in postmeiotic germ cells during mouse spermiogenesis. Mutant male mice lacking CREM expression are sterile due to lack of maturation of the germ cells. The main task of thesis was to determine the CREMtau downstream target genes, i.e. the genes which are down regulated or not expressed in CREM …
-
Identification of novel target genes for the plasticity-related transcription factor Zif268
… all models of neuronal plasticity. Downstream targets of zif268 are widely believed to contribute to the duration and stabilisation of NMDA receptor dependent LTP which, in turn, can be linked to various models of learning and memory. However, these downstream targets are only just starting to …
-
Identification of signalling pathways regulating TBX2 gene expression and its target genes
… cell cycle progression and also in the genesis of cancer. Importantly, the T-box factors Tbx2 and Tbx3 are overexpressed in several cancers including melanoma, small cell lung carcinoma, breast, pancreatic, liver and bladder cancers and can suppress senescence, a cellular process which …
-
Δnp63 Regulates A Complex Network of Target Genes In Limb and Epidermal Development
… defect by failure to silence pluripotency genes. Furthermore, I have observed that epidermal cells lacking ΔNp63 display a phenotype reminiscent of embryonic stem cells instead of keratinocytes. Thus, I hypothesize that genes involved in maintaining pluripotency, like Oct4, may be …
-
A Semi-Supervised Predictive Model to Link Regulatory Regions to Their Target Genes
… These non-coding DNA sequences can regulate genes from long distances, or across chromosomes, and their relationships with their target genes are not limited to one-to-one. With thousands of putative enhancers and less than 14,000 protein-coding genes, detecting enhancer-gene pairs becomes a …
-
Understanding HNF-1β through Identification of Interacting Proteins and Target Genes in the Kidney
… kidney developmental anomalies including renal agenesis, hypoplasia, and cysts. Here, I studied interacting proteins and target genes to understand the function of HNF-1Beta in the kidney. Yeast two-hybrid screening was performed to identify binding partners of HNF-1Beta in the kidney. Zyxin and …
-
An integrative approach to identify novel target genes for reduction of diacetyl production in lager yeast
Diacetyl ist ein Nebenprodukt der Biosynthese von Valin und verursacht einen butterartigen Geschmack im Bier. Die Reduktion der Diacetylproduktion ist eine der wichtigsten Ziele der Stammoptimierung von Brauhefen, da sie hilft, die Lagerzeit zu verkürzen und die Bierproduktion zu beschleunigen. Das …
-
Characterization of downstream target genes regulated by ABF-1 in different states of B cell development
… the role of ABF-1 in regulating downstream target genes in the human mature B cell line RAJI, as well as the plasma cell line, ARH-77. Quantitative real-time polymerase chain reaction and DNA microarray technology was used to investigate target genes that are subjected to transcriptional …
-
Correlation-based Linking of Epigenomic Regions to Target Genes in Bulk and Single Cell Epigenomic Data
Single-cell sequencing has catalyzed a significant shift in biological modeling and hypothesis generation. In this study, we present advanced algorithms that utilize multiple modalities for peak-gene linking via correlation-based mechanisms. This approach provides a robust framework for bias …
-
The Role of MicroRNA-378a-5p and its Target Genes in Differentiation and Fusion of BeWo Cells
… that miR-378a-5p inhibits STB differentiation by targeting cyclin G2 and targets Nodal that inhibits trophoblast invasion in extravillous trophoblast cells (EVTs). In this study, we have further investigated the role of miR-378a-5p and its target genes in STB differentiation by using a …
-
Identification and analysis of Il-2 induced Stat5 Target genes in Human CD4 and CD8 T cells
… to annotate and functionally classify the genes associated with<br/>binding sites, predicted novel functions for STAT5 such as transport and metabolism, in<br/>addition to previously known functions such as cell differentiation, proliferation, signal<br/>transduction, apoptosis and …
-
Gcn5 Impacts Fgf Signaling At Multiple Levels and Activates C-Myc Target Genes During Early Differentiation of Embryoid Bodies
… that parallel developmental events during embryogenesis <em>in vivo</em>.</p> <p>In this dissertation project, we use a murine ESC aggregation assay (embryoid body formation, EB) to model the early development stages that proceed gastrulation, and report that GCN5, a histone acetyltransferase …
-
Roles of Neurogenin and Geminin in Vertebrate Neurogensis
… of neurogenin and geminin in vertebrate neurogenesis Proneural basic helix-loop-helix transcription factors regulate cell fate commitment and differentiation in neurogenesis. However, their proneural functions are not well understood, in part due to a lack of information about their target …
-
Molecular Functions of MLL PHD3 Binding to Its Ligands Cyp33 and H3K4Me3
… results in transcriptional repression of MLL target genes.</p> <p>The aim of this study is to determine the biological function of MLL PHD3 binding to H3K4Me3 or Cyp33. Cyp33 binding to MLL PHD3 reduces the binding affinity of the MLL PHD3 for H3K4Me3 by 5.7 fold in vitro. To know if this is …
-
Effects of Anaerobic and Aerobic Digestion at Mesophilic and Thermophilic Temperatures on the Quantity of Carbapenem Resistance Genes in Wastewater Sludge
Antibiotic resistance genes (ARGs) encode resistance against antibiotic drugs in bacteria. Carbapenem antibiotics are one of the last lines of defence against bacterial infections and carbapenem resistance genes (CRGs) accumulate in sludge during wastewater treatment. Anaerobic and aerobic …
Page 1 of 29