Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"target dose"”.
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An Adaptive Dose Finding Design (DOSEFIND) Using A Nonlinear Dose Response Model
… trials are the first time that an NCE is dosed in human subjects, the designs used in these trials are unique and geared toward patient safety. We develop a method for obtaining the desired response using an adaptive non-linear approach. This method is applicable for studies in which MTD, …
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Interactive Effects of Bazedoxifene acetate and Conjugated Equine Estrogens on the Breast and Reproductive Tract of Postmenopausal Monkeys
… was to determine if BZA given at the clinical target dose of 20 mg/day would inhibit the proliferative effects of CEE (0.45 mg/day) on the breast and endometrium without attenuating the maturation effects of CEE on the vaginal mucosa. As part of a nonhuman primate translational trial evaluating …
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Guideline-led prescribing to heart failure patients in Ireland and Egypt
… are achieved with an appropriate prescription of target doses of all HF therapies. The degree to which gaps in medication use and dosing persist in contemporary Irish or Egyptian practices is unclear. Aim: To assess guideline-led prescribing of the evidence-based HF medications in routine clinical …
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Investigation of focused Very High Energy Electrons (VHEEs) as a new radiotherapy method
… is faced with the challenge of delivering doses which exceed standard clinical fractions to target radioresistant tumours. However, any dose escalation in the tumour is limited by radiation tolerance of healthy tissues,including skin, which is among the most sensitive tissue. An improved …
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The Effects of a Single Strain Bacillus subtilis DFM on pullet performance, laying hen performance, and egg quality when fed from day of hatch until 70 weeks
… treatments for 70-weeks. The DFM was added at a target dose of 300,000 cfu/kg of feed. At the end of the 17-week pullet phase, DFM fed pullets resulted in reduced feed intake, improved FCRm with both similar body weights (P = 0.98) and body composition (P > 0.05) to the control fed pullets. At 17 …
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MRI-based treatment plan simulation and adaptation for ion radiotherapy using a classification-based approach
… both MRI-based pseudo CT and reference CT and dose distributions were calculated on the reference CT. Finally, a target volume shift was simulated and employing a hybrid approach, a treatment plan adapted to the shift was optimized on the basis of a so-called corrected CT. The latter consisted …
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Auto-Delineation of Oropharyngeal Clinical Target Volumes Using Deep Learning Techniques
… radiotherapy by conforming radiation dose to the defined treatment targets achieving more accurate target dose distribution and better sparing of normal tissues. However, producing very precise treatment plans may be ineffective if the target volumes are not defined accurately. …
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Improvements In Robustness and Optimality of Intensity-Modulated Proton Therapy Plans For Lung Cancer Patients With 4-Dimensional Robust Optimization
… appropriate optimization strategy to make IMPT dose distributions less sensitive to both respiratory motion as well as to setup and range uncertainties simultaneously.</p> <p>For full 4DRO, the effect of respiratory motion, characterized by different phases of 4D computed tomography (CT), was …
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Scanned Ion Beam Therapy For Thoracic Tumors
… superior sparing of healthy tissue near moving targets, compared to other motion mitigation strategies. Furthermore, carbon-ion therapy can sometimes provide greater relative biological effectiveness (RBE) for cell sterilization in a target but nearly equivalent RBE in tissue upstream of the …
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Development of A Beam-Specific Planning Target Volume and A Robust Plan Analysis to ol For Proton Therapy
… growing increasingly popular due to its superior dose characteristics compared to conventional photon therapy. Protons travel a finite range in the patient body and stop, thereby delivering no dose beyond their range. However, because the range of a proton beam is heavily dependent on the tissue …
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Bayesian adaptive methods to incorporate preclinical data into phase I clinical trials
… the design and analysis of adaptive phase I dose-escalation trials. Specifically, our focus is on the transition step of early drug development, where phase I clinical trials are preceded only with some preclinical information. We see preclinical data as a special type of historical data, …