Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"tanycytes"”.
-
Investigation of Tanycytes and Orexin Neurons in the KCNA1-Null Mouse Model of Epilepsy
… neuronal excitability, and ectopic neurogenesis. Tanycytes are specialized ependymal cells lining the third ventricle (3V) and projecting to hypothalamic nuclei. They play a key role in maintaining the brain’s homeostasis. It remains unclear whether tanycytes are affected by SRS or whether …
-
Hypothalamic orexin neurons and tanycytes: Functional and molecular aspects in a mouse model of temporal lobe epilepsy
This dissertation does not include an abstract.
-
An emerging role for tcf7l2 at the nexus between metabolic regulation and social behavior
… signaling and hypothalamic plasticity: the tanycytes. Examining TCF7L2 chromatin binding and gene expression in cultured tanycytes derived from wild type and Tcf7l2 mutant mice, I present data suggesting a direct role modulating canonical WNT, BMP and glutamate signaling, and genes involved …
-
Neural Stem / Progenitor Cells in the Adult Mouse Hypothalamus
… data supports previous reports suggesting that tanycytes act as neural stem cells in the hypothalamus. Finally, I have started work investigating the control of hypothalamic stem / progenitor proliferation by fibroblast growth factors. I demonstrate that FGF signalling is necessary for in vitro …
-
Spinophilin Signaling: Impacts on Body Weight, Obesity, and Beta-Cell Function
… well as in other glucose-sensing cells known as tanycytes that neighbor the arcuate nucleus and the third ventricle. We found that loss of spinophilin limited weight gain observed in both a leptin receptor db/db mouse line (Leprdb/db) and mice fed a high-fat diet. Moreover, we found that the …
-
Uncovering the role of notch signaling in development of hypothalamic nuclei in vivo and using in vitro microenvironments
… such as glia, ependymal cells, and hypothalamic tanycytes. It is hypothesized that each of these cell types arise from a common progenitor early in development. Disruption during the developmental window of any of these cellular types can result in persistent health conditions related to the …
-
Evaluating the Effect of Chronic Alcohol, Cocaine, and Co-Administration on Endogenous Adult Neural Stem Cell Survival, Differentiation, and Proliferation
Cocaine and alcohol are two of the most commonly co-abused substances, and the third most fatal drug combination. Efforts in drug addiction research primarily focus on preventing or stopping abuse; however little work is being done to reverse brain damage incurred by chronic drug abuse. Neural stem …