Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 112 for “"tangles"”.
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The Multivariable Alexander Polynomial on Tangles
… invariant, which leads us to an extension to tangles. To define this invariant we use so-called circuit algebras, an extension of planar algebras which are the `right' setting to discuss virtual knots. Our tangle invariant is a circuit algebra morphism, and so behaves well under tangle …
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On a Heegaard Floer theory for tangles
… i.e. a Heegaard Floer homology HFT^ for tangles in the 3-ball. The decategorification of HFL^ is the classical Alexander polynomial for links; likewise, the decategorification of HFT^ gives a local version ∇ˢ of the Alexander polynomial. In the first chapter of this thesis, we give a …
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Constructing Hecke-type Structures, their Representations and Applications
… of a�ne Hecke algebras, emerging from tangles. Using these tangles we also obtain representations of the Temperley-Lieb algebra and the a�ne braid group. We conclude this thesis with our interpretation of the central role of the Hecke algebra in the development of knot theory. More …
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Neuropsychologische Testleistungen bei Patienten mit Koronarer Herzkrankheit und ihr Zusammenhang mit morphologischen Auffälligkeiten im cranialen Kernspintomogramm
… wie senile Plaques und neurofibrilläre tangles im Temporallappen insbesondere im Hippocampus, die bisher als typisch für Patienten mit Alzheimer-Demenz galten. Die vorliegende Arbeit sollte bei Patienten mit Koronarer Herzkrankheit kernspintomographisch die Häufigkeit …
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Investigating alterations in autophagy in Alzheimer’s disease using human brain tissue and skin-derived fibroblasts
… tau protein within neurofibrillary tangles and plaques containing amyloid-β (Aβ). Autophagy is a normal intracellular mechanism that functions to degrade damaged cellular proteins. Studies have shown that there is an association between the dysfunction of the two main autophagy …
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Phosphoproteomics analysis of Alzheimer's disease
… of amyloid-[beta] plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Despite numerous clinical trials, a limited understanding of disease pathogenesis has prevented the development of effective therapies. Several lines of genetic and biomolecular evidence …
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Molecular modeling and SAR studies of CDK5/p25 selective inhibitors
… of amyloid senile plaques and neurofibrillary tangles. Cyclin dependent kinase 5 (CDK5) is a proline directed serine/threonine kinase, which expressed primarily in the central nervous system. In the biochemical process the CDK5-natural activator, p35 is cleaved by calpain to a shorter protein …
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The Prostaglandin E2 Receptor Subtype 3E and its involvement in tauopathies
… suggested that it could be associated with tau tangles. The aim of this project was to further investigate the unknown distribution of EP3Re in human brain, to determine its signalling mechanism and explore whether any meaningful interaction between EP3Re, tau and its pathology exists. We use …
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Digital Morphometry : A Taxonomy Of Morphological Filters And Feature Parameters With Application To Alzheimer's Disease Research
… namely neuritic plaques and neurofibrillary tangles. They occur predominantly in the cerebral cortex and hippocampus. Quantitative studies of the distribution of plaques and tangles in normally aged and Alzheimer brains are hampered by the enormous amount of time and effort required to count …
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Computational studies of tau protein : implications for the pathogenesis and treatment of neurodegenerative diseases
… of protein aggregates known as neurofibrillary tangles, a pathological hallmark of Alzheimer's disease (AD). Previous studies suggest that tau protein may play a contributing role in neurodegenerative diseases such as AD. Thus characterizing the structural properties of tau is critical to …
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A streptozotocin-induced model of Alzheimer's disease in mice with wild-type human tau
… of tau, the main component of neurofibrillary tangles observed in AD, leads to deficits in cell structure and function. Because recent data suggest impairments in cerebral glucose utilization and energy metabolism play a prominent role in the pathogenesis of AD, we sought to create a mouse …
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Nicotinic acetylcholine receptors and their interaction with Aβ₁₋₄₂
… by the post-mortem presence of neurofibrillary tangles and amyloid plaques. At present ~ 5 % of those aged over 65 years are diagnosed with AD, with this figure increasing to ~ 20 % for those aged over 75 years. It is nearly 100 years since AD was first characterised in 1907, however the exact …
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Design and Synthesis of CDK-5 and MEK-5 Inhibitors and Synthesis towards Tubulysin Analogs
… protein tau, formation of neurofibrillary tangles, and possibly an acceleration of the neurodegenerative progression of Alzheimer's disease. C6-O linked benzimidazoles and C-4 benzamide and phenylacetamide benzimidazoles based on (R)-Roscovitine, a non-selective inhibitor of CDK-5 were …
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On the Breadth of the Jones Polynomial for Certain Classes of Knots and Links
… polynomial are constructed from special rational tangles expansions and using these formulas, we can extend these results to for [sic] special cases of Montesinos knots and links.
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Tau aggregation is heterogeneous across cases of sporadic Alzheimer's disease and is influenced by autophagy pathways in vitro
Tau neurofibrillary tangles or aggregates are a common neuropathological feature found in a number of neurodegenerative conditions, including Alzheimer's disease. Understanding the kinetics of this aggregate build up, how it varies across patients, and how aggregation might be influenced by …
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Rhetoric of trans* identities: public reactions to private confessions
… The implications of this identity work tangles with the reliance on personal experience as an expression of identity and its persuasive power to impact discourse. The linguistic tropes that confine identity expression inherently impact a community of individuals struggling to navigate …
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Some aspects of biochemistry of fibrous proteins in brain
… of the material that forms the neurofibrillary tangles in presenile and senile dementia. Suggestions are made about the nature and origin of these diseases. Some observations are also made about the protein skeletin, but because isolation and characterization methods currently available give …
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Proteomic-based Signature of Brain-related Proteins as Novel Candidate Biomarkers for Alzheimer’s Disease Diagnosis
… beta deposits and intracellular neurofibrillary tangles. Brain pathology is reflected in cerebrospinal fluid (CSF) where core biomarkers amyloid beta 1-42, total tau, and phosphorylated tau protein levels are changed relative to cognitively normal elderly. There is a need for novel …
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EPIGENETIC REGULATION IN AN IPSC-NEURON MODEL OF FAMILIAL ALZHEIMER’S DISEASE
… of amyloid plaques and tau neurofibrillary tangles in the brain. Dysregulation of epigenetic histone modifications may lead to the expression of transcriptional programs that may play a role in disease genesis or the worsening of disease pathology. One such histone modification, acetylation …
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A bright idea? : the promise and peril of a memory drug
… disease is caused not by amyloid plaques and tangles but by a gradual deterioration of the brain's synapses. Wurtman's drug-a cocktail of three dietary supplements including uridine, choline, and an omega-3 fatty acid called DHA-is designed to generate more synapses. The three ingredients …
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