Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"tail-anchored"”.
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Post-translational Insertion of a Small Tail-Anchored Protein into the Membrane of the Endoplasmic Reticulum
… targeting and insertion of the small, tail-anchored ER membrane protein RAMP4op was analyzed. RAMP4op has been chosen as a model because of its small overall length, carboxy terminal location of the transmembrane (TM) domain and the presence of the short cytoplasmic segment. This allows …
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Tail-anchored Triphosphate Tunnel Metalloenzymes in Arabidopsis thaliana: An Investigation into the Molecular Mechanisms underlying their Biological Functions
The Triphosphate Tunnel Metalloenzymes (TTMs) superfamily is a group of proteins that contain a tunnel-shaped β-barrel structure, called a TTM domain. They exist in all domains of life where they act on a range of triphosphate substrates. However, the biological function of most TTM proteins is not …
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Distinct C-terminal Amino Acid Sequence Motifs Serve as the Targeting Signals for Outer Mitochondrial Membrane and Plastid Outer Envelope TA Proteins
Tail-anchored (TA) proteins are a unique class of functionally diverse membrane proteins that are defined by their single C-terminal transmembrane domain and their ability to insert post-translationally into specific organelles in an Ncytosol-CIMS orientation. While in recent years considerable …
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Investigations Into the Function of Elp3 in Toxoplasma Gondii
… survey that discovered over 50 additional “tail-anchored” proteins present in Toxoplasma. Mutational analyses found that targeting of these TA proteins to specific parasite organelles was strongly influenced by the TMD sequence, including charge of the flanking C-terminal sequence.
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Regulation of the Target of Rapamycin Signaling Pathway in Saccharomyces cerevisiae
… (ER). The data show that Far9 and Far10 are tail-anchored proteins that localize to the ER first and recruit a Far8-Far7-Far3 pre-complex. Far11 is found at the ER only when all other Far proteins are assembled at the ER. Surprisingly, ER localization is required for the Far Complex’s role …
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Structure and Function of the ER-Membrane Complex
… roles been characterised in the insertion of tail-anchored proteins and in defining the topology of the first transmembrane helix in GPCRs. In this thesis I investigate the role of the EMC in the biogenesis of misfolded ABC transporters Yor1$\Delta$FRT and the homologous CFTR$\Delta$F. I …
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Uncovering the biogenesis pathways for human mitochondrial alpha-helical outer membrane proteins using genome-wide approaches
… Alpha-helical proteins are classified as signal-anchored (a single N-terminal anchored TMD), tail-anchored (a single C-terminal anchored TMD) and polytopic (multiple TMDs), by the number and orientation of their TMDs with respect to the membrane. While the novel OMM insertase MTCH2 was discovered …
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Molecular Dissection of Multifunctional Proteins in Rod Outer Segments
… recombinant adeno-associated virus.</p><p>The tail-anchored protein R9AP, in conjunction with RGS9-1 and G-beta5, comprises the transducin GTPase activating complex, which catalyzes the rate-limiting step in rod photoresponse recovery. In addition to maximizing the enzymatic activity of the …
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Membrane protein biosynthesis at the endoplasmic reticulum
… investigation of a simpler class of proteins. Tail-anchored proteins (TA) are characterized by a single C-terminal hydrophobic domain that anchors them into membranes. Though structurally simpler compared to multi-pass IMPs, the TMDs of TA proteins are similarly diverse. We found that known TA …
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TREX1 C-Terminus Regulates Oligosaccharyltransfererase to Prevent the Accumulation of an Endogenous Bioactive Disaccharide Associated with Autoimmune Disorders
… is a 314 amino acid endoplasmic reticulum (ER) tail-anchored 3' exonuclease where the N-terminal region contains the DNase domain and the C-terminal end controls TREX1 localization to the surface of the ER. Disease mutations that abrogate the N-terminal DNase function of TREX1 lead to chronic …
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SOTTODOMINI DEL RETICOLO ENDOPLASMATICO IN FISIOLOGIA E PATOLOGIA
… a membrane protein with a C-terminal anchor (“tail-anchored”), which is resident in the endoplasmic reticulum, whose P56S mutation induces large perinuclear inclusions formation. Considering that such aggregates haven’t still clearly related to any cellular organelle, I decided to study the …