Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"tacrolimus"”.
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Ex-vivo Untersuchungen zur Arzneimittelwirkung topischer Tacrolimus (FK-506) Anwendung auf epidermale dendritische Zellen in läsionaler Haut bei Patienten mit atopischem Ekzem
Topical tacrolimus (FK506) leads to profound phenotypic and functional alterations of epidermal antigen-presenting dendritic cells in atopic dermatitis. BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease in which antigen-presenting epidermal dendritic cells (DCs), ie, …
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Genotypes and Clinical Characteristics of BK Virus in Kidney Transplant Recipients
… With respect to the risk factors of BK virus, tacrolimus and mycophenolate mofetil when combined with tacrolimus were found to be significantly associated with BK viruria and viremia. CONCLUSIONS: It appears that different variants of BK virus are prevalent in Korea compared with the Western …
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The calcineurin inhibitor cyclosporine A activates the renal Na-(K)-Cl cotransporters via local and systemic mechanisms
… inhibitors (CNIs) cyclosporine A (CsA) and tacrolimus are potent immunosuppressive drugs that have become indispensable in the post-transplantational therapy and in the treatment of autoimmune diseases. Immunosuppression via CNIs is achieved by inhibition of the calcineurin phosphatase and …
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A Tissue-Engineered Blood Vessel Model for Vascular Aging
… Dasatinib and quercetin, two senolytics, and tacrolimus, a senomorphic, were tested on CBECFCs growing in 2-D to see if they were effective at reducing the percentage of p21 positive (senescent) cells. Tacrolimus was found to be the best candidate and used in TEBV trials. TEBVs treated with …
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Biocapteur électrochimique pour la quantification d’un immunosuppresseur
… tels que la cyclosporine A (CsA) et le tacrolimus. Ces traitements indispensables à la prévention du rejet doivent rigoureusement être contrôlés, car une concentration trop faible conduit au rejet du greffon, tandis qu’un excès devient toxique pour la santé. Aujourd'hui, le suivi …
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Outcomes of renal transplantation in patients with lupus nephritis: a single centre study in Cape Town
… and azathioprine; in 2/15 (13.3%) with tacrolimus and azathioprine and in 6/15 (40.0%) with Tacrolimus and MMF. All patients received corticosteroids. Recurrence of LN was seen in one patient (6.7%) who developed class V LN. Graft rejection was diagnosed in 10/15 cases (66.7%) with types …
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Nanomicelles And Liposomes For Improving Drug Delivery of Small Molecules And siRNA Therapeutic Agents
PART I: SELF-ASSEMBLING TACROLIMUS NANOMICELLES FOR BACK OF THE EYE DISEASES Vrinda Gote, Candidate for the Doctor of Philosophy Degree University of Missouri-Kansas City, 2021 ABSTRACT Neovascular age-related macular degeneration (AMD) is characterized by increase in reactive oxygen species (ROS) …
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Production of Polyhydroxyalkanoates and their application for coronary stent development
… PCL-PEG550 with incorporated drugs: rapamycin or tacrolimus was carried out for the development of a drug eluting biodegradable stent. The percentage viability of the HMEC-1 cells was significantly higher on the tubes with tacrolimus compared to the tubes with rapamycin. Controlled release of both …
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RUOLO DEI POLIMORFISMI GENETICI DEL IL-28B NELLE COMPLICANZE BILIARI POST-TRAPIANTO DI FEGATO NELL'ADULTO
… principale o la Ciclosporina (N. = 55) o il Tacrolimus (N. = 119), associati durante i primi 3-6 mesi post trapianto ai corticosteroidi. Dopo aver posto il sospetto clinico di complicanza biliare, laboratoristico e radiologico di una complicanza biliare, il paziente è stato sottoposto ad …
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The susceptibility of baboons to the novel immunosuppressant, FTY720
… agents such as Cyc1osporine A and Tacrolimus have significantly improved the survival of organ transplants. However, although there is a good 1-5 year survival, the recurrent problem of chronic rejection still remains, and unresponsiveness to allografts has never been induced by …
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A Study of Craniofacial Growth in Infant Heart Transplant Recipients Receiving Cyclosporine
… of the subjects received the immunosupressant tacrolimus (FK506). Using lateral cephalometric radiography, seven skeletal angular measurements (SNA, SNB, ANB, GoGn-SN, NA-Pog, ArGoMe, NPog-AB) were examined and compared to contemporary growth standards. Hand/wrist radiographs were evaluated for …
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A systematic review of treatments for atopic dermatitis
… UV light, ascomycin derivatives, topical tacrolimus and oral cyclosporin. Treatments that show limited evidence of a benefit include non-sedatory antihistamines, topical doxepin, the oral antibiotic Cefadroxil on clinically infected AD, the topical antibacterial Mupirocin on clinically …
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Biosynthesis of Poly-3-Hydroxybutyrate and its Application in Controlled Drug Delivery
… two antiproliferative drugs namely rapamycin and tacrolimus were studied in the context of their application in drug eluting stents. Rapamycin encapsulated P(3HB) and PLLA microspheres were compared for their physical properties and drug release kinetics and their release kinetics were found to be …
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Analysis of the Metabolism of Dextran-Methylprednisolone Succinate Using
… including corticosteroids,cyclosporine A, and tacrolimus as they relate to liver transplantation is presented. The most common and detrimental side effects are presented for each therapy, and a method to reduce these adverse effects is proposed. As a method of drug delivery targeted to the …
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Vesetranszplantáció után kialakuló húgyúti fertőzések rizikófaktorai különös tekintettel néhány recipiens tényezőre
… (p<0,001) és a nem elnyújtott hatástartamú tacrolimus készítmények (p<0,001) alkalmazása. A multirezisztens fertőzések kialakulásának esélyét szignifikánsan növelte, ha a beteg testtömeg indexe nagyobb volt mint 25 kg/m2(p=0,005), a retranszplantált státusz (p=0,037) és a magasabb SCORE2 …
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Análisis obsevacional para evaluar la eficacia y seguridad de los mTORi en la esfera oncológica en el paciente trasplantado hepático
… treatment based on calcineurin inhibitor (CNI, tacrolimus, cyclosporine), controls the appearance of rejection but favor the appearance and proliferation of neoplastic cells by relaxation of the immune tumor surveillance. The appearance of mTOR inhibitors (mTORi, sirolimus, everolimus) within …
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A Continued Investigation of Craniofacial Growth in Infant Heart Transplant Recipients Receiving Cyclosporine
… of the subjects received the immunosuppressant tacrolimus (FK506). Using lateral cephalometric radiography, seven skeletal angular measurements (SNA, SNB, ANB, GoGn-SN, NA-Pog, ArGoMe, Npog-AB) were examined and compared to contemporary cephalometric norms. Hand/wrist radiographs were evaluated …
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The Development of Methods to Account for Physiologic Dynamic Changes and Their Effects on the Pharmacokinetics of Therapeutic Monoclonal Antibodies and other Therapeutics
… groups also received either methotrexate or tacrolimus/sirolimus immune suppression. Methotrexate significantly lowered the incidence of anti-variable region antibodies at moderate mAb dose (P<0.05), while tacrolimus/sirolimus did likewise at moderate and high doses (P<0.01) of mAb. With the …
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Gene Therapy and Stem Cell Therapy to Improve the Outcome of Human Islet Transplantation
… with two immunosuppressive drugs, sirolimus and tacrolimus and a monoclonal antibody drug daclizumab to prevent the graft rejection. However, despite the administration of immunosuppressive drugs and the recent improvement in islet isolation, preparation and transplantation, insulin independence …
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