Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"tRNA processing"”.
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Characterizing Human Transfer RNAs by Hydro-tRNAseq and PAR-CLIP
<p>The participation of tRNAs in fundamental aspects of biology and disease necessitates an accurate, experimentally confirmed annotation of tRNA genes, and curation of precursor and mature tRNA sequences. This has been challenging, mainly because RNA secondary structure and nucleotide …
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Local and global investigations into DEAD-box protein function
… cellular processes, such as gene regulation and tRNA processing, are carried out by structured RNAs. While in vitro most RNAs become kinetically trapped in non-functional misfolded states that render them inactive on a biologically-relevant time scale, RNAs folding in vivo do not share this same …
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Intracellular Traits of Chimeric tRNAlys3-ribozymes and their Inhibition of HIV
<p>Host tRNALYs3is the primer recruited by HIV-1 for initiating reverse transcription. When ribozymes targeted upstream of the primer binding site of the HIV-1 genome are tethered to the 3' end of the tRNALYs3, it is expected that the tRNA will carry the ribozymes into the virions. We made …
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Establishing new approaches to unveil regulatory functions of tRNAs and their interactors
… study living systems. However, once the role of tRNAs was established in protein synthesis, the field moved on to other areas of the RNA world. With the mainstream application of systems-wide approaches, tRNAs have emerged as implicated in multiple regulatory networks beyond translation. These …
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Dissecting the regulatory roles and cellular functions of mammalian ZSCAN5B and primate-specific paralogs
… as a protein that binds with high specificity to tRNA genes (tDNA) and other polymerase III (Pol III) transcripts including several types of transposable elements (TEs). Primate-specific paralogs ZSCAN5A and ZSCAN5D also bind tDNAs, although ZSCAN5D preferentially recognizes a subset of TE-derived …
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Functions of The Trna Splicing Endonuclease and Other Adventures In Rna Processing
<p>The tRNA splicing endonuclease (TSEN), has been studied for over three decades for its function in tRNA splicing. However, this enzyme has other functions that are just beginning to be characterized. Mutations in TSEN cause the neuronal disease pontocerebellar hypoplasia (PCH) that is …