Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"tRNA modifications"”.
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GUIDE RNA-DEPENDENT AND INDEPENDENT tRNA MODIFICATIONS IN ARCHAEA
… undergo a wide variety of post-transcriptional modifications, that add to the functional repertoire of these molecules. Some of these modifications are catalyzed by stand-alone protein enzymes, while some others are catalyzed by RNA-protein complexes. tRNAs from all domains of life contain many …
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A systems-level analysis of dynamic reprogramming of RNA modifications in the translational control of cellular responses
… uridine, guanosine, cytosine), transfer RNAs (tRNA) and ribosomal RNAs (rRNA) are comprised of more than 100 enzyme-catalyzed modifications, with about 20-35 found in any one organism. Many of these modifications are highly conserved in all domains of life, which suggests important biological …
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The physiological consequences of loss of tRNA thiolation in Saccharomyces cerevisiae
… modifier, functions as a sulfur carrier in tRNA thiolation reactions. Urml is required for formation of the s2 moiety that is found as part of the more complex mcm5 s2 U34 modification on the anticodon wobble uridines of tGliUUC, of tGgluUUG and tLysUUU tRNAs in a variety of organisms. It …
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Investigations Into the Function of Elp3 in Toxoplasma Gondii
… (rSAM) domain is important for the formation of tRNA modifications, which enhance translation efficiency and fidelity. Given its location, histones would not be an expected substrate, and we further determined that tubulin acetylation in Toxoplasma is mediated by a different enzyme, TgATAT. We …
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Nucleic acid modifications in bacterial pathogens - impact on pathogenesis, diagnosis, and therapy
… chemical modification by all organisms. These modifications display incredible structural diversity, and some are essential for survival. Intriguingly, several of these modifications are unique to bacteria, including many human pathogens. Given the enormous global disease burden due to …
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A systems biology approach unravels the biological function of two tRNA wobble base modifications in fine-tuning translation and the response to environmental stress
tRNA molecules undergo extensive post-transcriptional modifications to produce several variations of the four canonical nucleotides. Despite the huge number of nucleotide modifications that have been identified in tRNAs, to date their biological roles and regulations continue to be poorly …
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Development and Application of Mass Spectrometry Based Methodologies to Study Ubiquitin-Like Modifiers
… including modification of proteins, lipids, and tRNA. Analysis of both UBL conjugation sites and characterisation of system wide proteome responses is essential to understanding the impact UBLs have on regulating cellular systems. While mass spectrometry is a powerful analytical technique, …
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Orthogonal pair-directed codon reassignment as a tool for evaluating the factors affecting translation in E. coli
… on using an engineered orthogonal aminoacyl-tRNA and aminoacyl tRNA-synthetase pairs (tRNA/aaRS) to direct incorporation of ncAAs at amber stop codons. In order to further expand the genetic code to 22 or more amino acids, additional codons must be targeted for reassignment to ncAAs. The …
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The Role of tRNA methyltransferases in Cancer
RNA modifications have emerged as pivotal regulators of cellular homeostasis, stress adapta- tion, and disease, particularly within the context of cancer. Among these, tRNA modifications play a crucial role in maintaining translational fidelity and supporting cancer cell survival under adverse …