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Showing 1 to 15 of 15 for “"tRNA modification"”.
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Characterisation of the Essential t<sup>6</sup>A tRNA Modification Enzymes and Evaluation as a Potential Novel Antimicrobial Target
… are common, with over one-hundred individual modifications reported to date. In transfer RNA (tRNA), these modifications help hold the molecule in its proper conformation, allow the aminoacyl-synthetases to attach the amino acid to the correct tRNA for transfer to the ribosome, and in the …
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Determinants of translational efficiency in Saccharomyces cerevisiae
… I investigate the role of a conserved anticodon tRNA modification in determining the rate of translation elongation and the phenotypic consequences of its loss for budding yeast. In Chapter 3, I discuss the regulation of translation initiation to introduce Chapter 4, in which I explore how the …
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Archaeal Gene Identification
… bacterial and eucaryal homologs. Studies of tRNA modification enzymes from M. jannaschii identify 7 enzymes, which use S-adenosylmethionine to methylate tRNAs in vitro . Inferred phylogenies of these enzymes imply that most were present in an ancestor of the archaeal/eucaryal lineage. …
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The physiological consequences of loss of tRNA thiolation in Saccharomyces cerevisiae
… modifier, functions as a sulfur carrier in tRNA thiolation reactions. Urml is required for formation of the s2 moiety that is found as part of the more complex mcm5 s2 U34 modification on the anticodon wobble uridines of tGliUUC, of tGgluUUG and tLysUUU tRNAs in a variety of organisms. It …
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An Investigation into the Effects of Alterations in Ribosomal Proteins S4 and S5 on Translational Accuracy, Ribosomal RNA Processing, and Ribosome Assembly
… indirectly by affecting amino acid pools or tRNA modification.
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A systems-level analysis of dynamic reprogramming of RNA modifications in the translational control of cellular responses
… uridine, guanosine, cytosine), transfer RNAs (tRNA) and ribosomal RNAs (rRNA) are comprised of more than 100 enzyme-catalyzed modifications, with about 20-35 found in any one organism. Many of these modifications are highly conserved in all domains of life, which suggests important biological …
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The Role of Queuine Deficient tRNA in Translational Control
… research was to study the effect of the level of tRNA modification with respect to queuine on translational efficiency. Transfer RNA from neoplastic cells is generally deficient with regard to certain hypermodified nucleosides found in normal cells. The hypothesis that was examined is whether or …
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The Role of tRNA methyltransferases in Cancer
RNA modifications have emerged as pivotal regulators of cellular homeostasis, stress adapta- tion, and disease, particularly within the context of cancer. Among these, tRNA modifications play a crucial role in maintaining translational fidelity and supporting cancer cell survival under adverse …
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Role of RNA methyltransferases in lung cancer
… project, THUMPD3 was reported to catalyse m²G in tRNAs. However, whether THUMPD3 also methylates non-tRNA substrates was not addressed. My project sought to address whether other RNAs are indeed m²G modified by THUMPD3 and to further investigate and validate the role of the enzyme in lung cancer …
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GUIDE RNA-DEPENDENT AND INDEPENDENT tRNA MODIFICATIONS IN ARCHAEA
… undergo a wide variety of post-transcriptional modifications, that add to the functional repertoire of these molecules. Some of these modifications are catalyzed by stand-alone protein enzymes, while some others are catalyzed by RNA-protein complexes. tRNAs from all domains of life contain many …
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A TALE OF TWO METHYLATION MODIFICATIONS IN ARCHAEAL RNAs
… of life, most RNAs undergo post transcriptional modifications both on the bases as well as the ribose sugars of the individual ribonucleotides. 2'-O-methylation of ribose sugars and isomerization of Uridines to Pseudouridines are two most predominant modifications in rRNAs and tRNAs across all …
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Uncovering pathways necessary for the survival of RNase H-deficient Escherichia coli
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01
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Versuche zur Strukturaufklärung bakterieller Thiouridin Synthetasen
… allen rezenten Organismen ist bekannt, dass ihre tRNA posttrans-kriptional modifiziert wird. Ein Beispiel für diese Modifikationen ist die Insertion von Schwefel, wie sie durch die beiden Sulfurtransferasen ThiI und MnmA katalysiert wird. ThiI katalysiert die Insertion von Schwefel an Position 8 …