Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"tRNA methyltransferases"”.
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The Role of tRNA methyltransferases in Cancer
… within the context of cancer. Among these, tRNA modifications play a crucial role in maintaining translational fidelity and supporting cancer cell survival under adverse conditions. This thesis explores the contribution of two tRNA methyltrans- ferases - TRMT1, responsible for catalysing the …
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Characterization of mutant N², N²-dimethylguanosine-specific tRNA methyltransferases from Saccharomyces cerevisiae
$N\sp2,N\sp2$-dimethylguanosine-specific tRNA methyltransferase (m$\sbsp{2}{2}$Gtase) is an enzyme which uses S-adenosylmethionine as a substrate to catalyze the transfer of two methyl groups to the 2-amino group of guanosine at position 26 in tRNA. Neither the tertiary structure nor the location …
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Archaeal Gene Identification
… bacterial and eucaryal homologs. Studies of tRNA modification enzymes from M. jannaschii identify 7 enzymes, which use S-adenosylmethionine to methylate tRNAs in vitro . Inferred phylogenies of these enzymes imply that most were present in an ancestor of the archaeal/eucaryal lineage. …