Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"tRNA isoacceptors"”.
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Tumor Suppression by a TRNA Synthetase
… we report the surprising finding that leucyl-tRNA synthetase (LARS), a tRNA synthetase responsible for ligating leucine to corresponding leucyl-tRNAs, becomes strongly repressed during mammary cell transformation and in breast cancer. Monoallelic genetic inactivation of LARS in mouse mammary …
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A multiplexed approach for quantitative profiling of the translatome using bioorthogonal non-canonical amino acids
… Changes in chemical modifications of tRNA isoacceptors were also observed which may play a role in regulating protein translation. Finally, our multiplexed BONCAT method was leveraged to compare the translation response between MEK inhibitor resistant (MelJuso) and sensitive (MM415) …
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Mechanisms of Evasion: Anti-Tumor Immune Suppression & TRNA-Dependent Growth in Cancer Metastasis
… development to measure small RNA species, tRNAs have emerged as significant regulators of gene expression. The human genome contains 61 codons that are recognized by distinct transfer RNAs (tRNAs). We report the surprising observation that two isoacceptor tRNAs that decode synonymous codons …