Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"tRNA fragmentation"”.
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Tumor Suppression by a TRNA Synthetase
… we report the surprising finding that leucyl-tRNA synthetase (LARS), a tRNA synthetase responsible for ligating leucine to corresponding leucyl-tRNAs, becomes strongly repressed during mammary cell transformation and in breast cancer. Monoallelic genetic inactivation of LARS in mouse mammary …
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A Stress-Induced TRNA Depletion Response Mediates Codon-Based Translational Repression and Growth Suppression
<p>Eukaryotic transfer RNAs (tRNAs) can become fragmented upon various cellular stresses, generating tRNA-derived RNA fragments (tRFs). Though this process has been observed for numerous cellular stresses and in many species ranging from plant cells to yeast and human cells, it is still poorly …
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RNA modifications and processing in cell homeostasis and in response to oxidative stress
… NSun2 methylates cytosine-5 in most tRNAs and, to a lesser extent, other ncRNAs and mRNAs. Srsf2 is a critical component of the spliceosome and interacts with abundant ncRNAs that are methylated by NSun2. However, how precisely these processes effect homeostasis is largely unexplored. …