Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"t-loops"”.
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Mechanisms of Telomere End Protection by TRF2
… is also necessary and sufficient for forming t-loops, lariat-like structures that sequester the ends of telomeric DNA. In the absence of TRF2, t-loops are lost, ATM is activated, and telomeres fuse together via cNHEJ. While t-loops have been presented as an elegant solution to the end protection …
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Development of a T-Loop Assay to Investigate T-Loop Dynamics and Structure
… critical in maintaining genomic stability. T-loops, formed by the 3’ overhang inserting into the double strand region of the telomere, are thought to protect the ends from being recognized as double-strand breaks. An almost universal marker for cancer, telomerase, is a promising therapeutic …
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Testing the T-loop Model of Telomeric End Protection
… loop – known as the t-loop. Together, TRF2 and t-loops are the main pillars of the t-loop model of end-protection, which is the focus of this thesis. The first part of this thesis presents an overview of telomere protection and focuses specifically on what is known about end-protection in …
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Antigenic Variation and Telomere Structure in Trypanosoma brucei
… telomeres fold back in structures known as t-loops, in which the overhang is intercalated in the duplex DNA. The length of the TTAGGG tracts was measured (~15 kb) and the presence of 3' overhangs was established in trypanosome telomeric DNA. EM studies revealed the presence of t-loops in …
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The effects of high temperature metamorphic and melting processes on granulite-facies rocks
… late temperature maxima, and tight clockwise P–T loops. Petrochronology (the nexus between the isotopic age of a mineral and its compositional controls) is being increasingly used to interrogate the thermobarometric record contained in metamorphic rocks. Combined zircon and monazite REE-isotopic …
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Functional Analysis of the Human Telomeric Protein TRF2
… into large lasso-like structures named t-loops. Removal of TRF2 from telomeres by expression of a dominant negative allele of TRF2 (TRF2ΔBΔM) led dissolution of these structures and appearance of end-to-end fusions visible in metaphase and anaphase cells. Fusion formation was accompanied …
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Decoding aberrant RNA Synthesis by the Influenza A Virus
… mvRNAs are poorly replicated and strong t-loops are even capable of FluPolA stalling. Further experiments show that FluPolA stalling does not result in release of the mvRNA templates or nascent RNAs, but instead I observe that the stalled mvRNA- FluPolA complex itself activates innate …