Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"t-cell-lymphoma"”.
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Multilevel Deregulation of Survival Mechanisms In Npm-Alk+ T-Cell Lymphoma
<p>The anaplastic lymphoma kinase (ALK) is a single chain transmembrane receptor tyrosine kinase that belongs to the insulin receptor superfamily. Other members of this superfamily include the insulin receptor (IR), type I insulin-like growth factor receptor (IGF-IR), and the leukocyte tyrosine …
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Expression of Follicular Helper T-cell Markers in Primary Cutaneous T-cell Lymphoma
… and objectives: A distinct subset of T helper cells, named follicular helper T- (TFH) cells, have been recently described. The TFH-cells can be identified on the basis of the expression of several markers including: the chemokine CXCL13; the costimulatory molecules PD-1 and inducible …
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Metabolic regulation in Phosphatase and tensin homologue (PTEN) null T cell lymphoma/leukaemia cells
Deletion of PTEN selectively in T cell progenitors in the thymus results in the rapid development of aggressive T cell lymphomas in a mouse model for T-ALL. We showed that PTEN-/- T cell lymphoma/leukaemia cells were metabolically active as they readily took up key nutrients. Thus, they had high …
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Exploring the genetic landscape in cutaneous T-cell lymphoma with short- and long-read sequencing
Exploring the genetic landscape in cutaneous T-cell lymphoma with short- and long-read sequencing<br /> Carsten Hain<br /> #### Abstract Cutaneous T-cell lymphoma (CTCL) are a group of diseases with heterogenous genetic alterations. In general, there are recurrent copy-number variants and rare, …
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Immunological Mechanisms of Extracorporeal Photopheresis In Cutaneous T Cell Lymphoma and Graft Versus Host Disease
… OF EXTRACORPOREAL PHOTOPHERESIS IN CUTANEOUS T CELL LYMPHOMA AND GRAFT VERSUS HOST DISEASE</strong></p> <p>Publication No.___________</p> <p>Lisa Harn-Ging Shiue, B.S.</p> <p>Supervisory Professor: Madeleine Duvic, M.D.</p> <p>Extracorporeal photopheresis (ECP) is an effective, low-risk …
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Identification of differentially expressed genes in AHI-1-mediated leukemic transformation in cutaneous t-cell lymphoma
… insertional mutagenesis in murine leukemias and lymphomas. Its involvement in human leukemogenesis is demonstrated by gross perturbations in its expression in several leukemic cells lines, particularly in cutaneous T-cell lymphoma (CTCL) cell lines (Hut 78 and Hut 102). Hut 78 is derived from a …
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Spatial transcriptomic analysis of low-grade intestinal T-cell lymphoma and lymphoplasmacytic inflammatory bowel disease in cats
Alimentary lymphoma is the most prevalent neoplastic disease that affects the gastrointestinal tract of cats. In most cases, the neoplastic cell population is composed of small T lymphocytes primarily located in the intestinal mucosa, but can often invade deeper intestinal layers. It is a low-grade …
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A candidate gene based investigation of aberrant DNA methylation in the pathogenesis of primary cutaneous T-cell lymphoma
Primary cutaneous T-cell lymphoma (CTCL) is a clinically heterogeneous malignancy of mature skin-homing T-cells. Mycosis fungoides (MF) is an indo¬lent subtype of CTCL whilst Sezary syndrome (SS) is an aggressive leukaemic variant characterised by the presence of malignant Sezary cells in the …
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A study of activation antigens involved in the pathologicalmechanisms and pathways of cutaneous malignant disease withparticular emphasis on cutaneous T cell lymphoma andmalignant melanoma
… correlation. The studies into cutaneous T cell lymphoma (CTCL) and malignant melanoma (MM), presented here involved predominantly immunocytochemical procedures and relate to the investigations into AP-1 protein expression in CTCL and melanocyte activation antigens in MM. Results: Findings …
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Searching for the missing T Cell Receptor (TCR) in Anaplastic Large Cell Lymphoma (ALCL): Surplus to requirements or a protagonist in lymphomagenesis?
Anaplastic Large Cell Lymphoma (ALCL) is a peripheral T cell lymphoma divided into three distinct entities: ALCL, Anaplastic Lymphoma Kinase (ALK)+, ALCL ALK- and cutaneous ALCL. In the majority of ALCL, ALK+, ALK is expressed as the result of a chromosomal translocation generating Nucleophosmin …
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An improved synthesis of the HDAC inhibitor trichostatin A
… their specific apoptotic action towards cancer cells. Several hydroxamate HDIs have since been moved on to phase 1 and 2 clinical drug trials, with one having already been approved for treatment of advanced cutaneous T-cell lymphoma. Trichostatin A is one of the most potent known …
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Development of chemical inducers of dimerization for screening competitive histone deactelyase inhibitors
… been FDA approved for treatment of cutaneous T-Cell lymphoma. Currently, most of the known HDAC inhibitors are non-selective, which causes non-specific binding to the active sites of all HDAC isoforms, including those not involved in cancer. To date, screening for HDAC inhibitors has been done …
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Providing a Malleable, Genetically Defined Cancer Model: A Porcine Solution
… malleable, large animal solid tumor and T-cell lymphoma models utilizing the pig was developed. Primary porcine cells were genetically engineered to be tumorigenic through the altered expression of proteins known to disrupt pathways commonly affected in human cancers. The transformed …
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Role of autocrine growth factors in the tumorigenic transformation of T cells
… hypothesis that tumorigenic transformation of T cells may result from aberrant regulation of autocrine growth factor production. We describe for the first time characterization of several normal T cell lines that underwent spontaneous transformation resulting from constitutive expression of …
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THE DEVELOPMENT OF SELECTIVE PHOTOSENSITIZERS TO TARGET PATHOGENIC T CELLS AND PREVENT GRAFT-VERSUS-HOST DISEASE
… and alloimmune diseases. In hematopoietic stem cell transplantation, acute graft-versus-host-disease (GVHD) is caused by an attack on the recipient's tissues from donor allogeneic T cells. In cutaneous T cell lymphoma (CTCL), malignant T cells migrate throughout the skin to mediate the disease. …
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The Lived Experience of a Bone Marrow Transplant Survivor
… cancer. Then in 1931 he was diagnosed with T-cell lymphoma and underwent BMT in the summer of 1992. The data collection instrument utilized in this study assisted in obtaining descriptive information from five, one-hour, face-to-face focused taped interviews. Through taped interviews, the …
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Investigating lesions of Langerhans cells and their role in Lymphoproliferative diseases
Langerhan’s cells (LCs) are the immune sentinels of the skin, sampling the cutaneous microenvironment and presenting captured antigen to T cells. A sheet-like proliferation of LCs is termed Langerhan’s cell histiocytosis (LCH), an enigmatic and poorly understood disorder with a widely varied …
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Development Of Elisa-Based Hdac Activity Assay For Identification Of Isoform Selective Hdac Inhibitors
… drugs for the treatment of cutaneous T-cell lymphoma. Human HDAC proteins have high sequence similarity and hence many known inhibitors non-specifically interact with all or most of the eleven HDAC isoforms, leading to possible side-effects. Hence, HDAC inhibitors specific to one HDAC …
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Ctla-4 transcriptional activation: regulation of induced expression
… T-lymphocyte antigen 4 (CTLA-4) is a T cell surface protein that is homologous to CD28 and binds to the B7 family of ligands. Unlike CD28, CTLA-4 interaction transmits a negative signal in T cells, leading to suppression of proliferation. CTLA-4 is constitutively expressed on regulatory …
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