Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"t-PA"”.
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Epigenetic influence on cardiovascular protective mechanisms in vivo: explorations of t-PA release and extracellular vesicle genetic content
… mechanism was assessed, as well as the capacity of extracellular vesicle (EV) involvement in mediating epigenetic changes related to cardioprotection in ischemic preconditioning (IPC). Aims: The aim of Papers I and II was to evaluate if histone deacetylase inhibition, by valproic acid …
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The role of platelets and leukocytes in endogenous fibrinolysis.
The impact of intravascular aggregation of circulating platelets and white blood cells on the plasma activity of t-PA and PAI-1 was measured. In vivo platelet and white blood cell aggregation was induced by platelet and white blood cell agonists, the effect being monitored by the Technicon …
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Blood Pressure Elevation - Impact on Cardiovascular Structure and Endogenous Fibrinolysis
… research group recently discovered that the capacity for activation of the endogenous fibrinolytic system by acute release of tissue plasminogen activator (t-PA) is markedly impaired in subjects with hypertension. This impairment could contribute to the increased risk for atherothrombotic …
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Cardioprotective treatment strategies
… activation, tissue plasminogen activator (t-PA) and extracellular adenosine triphosphate (ATP) release contribute to myocardial injury. ATP is degraded into adenosine by the enzyme apyrase, and adenosine possesses cardioprotective properties. ADC-1004 is an antagonist of the receptor to the …
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Effect of dietary fibre on selected haemostatic variables and C-reactive protein
… factors tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor type 1 (PAI-1), factor VII (FVII) and fibrinogen and more recently, C-reactive protein (CRP), a sensitive marker of inflammation. Epidemiological studies have demonstrated an inverse association between dietary …
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Decrease Arrival to CT Time to Improve Stroke Outcomes
… of the project is to decrease the arrival to t-PA treatment times to <45 minutes in > 50% of the cases. The decreased treatment time will prove to shorten the average length of stay on average by two days (Audebert & Sobesky, 2014). The goal will be accomplished by decreasing the arrival to …
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Effects of air pollution on vascular thrombosis
Increases in air pollution, especially the particulate component, are associated with increased cardiovascular mortality, possibly through increases in thrombogenic mechanisms. The research presented in this thesis addresses the hypothesis that diesel exhaust particulates (DEP) increase …
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Coronary Reactive Hyperemia
… blood cells as well as an increased release of t-PA. It was also hypothesized that hypothermia may have effects on coronary reactive hyperemia and that rapidly induced hypothermia prior to reperfusion in an infarction model could reduce myocardial infarct size. Material and Methods: All studies …
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Antifibrinolytische Eigenschaften humaner Mesothelzellen in vitro in Interaktion mit isolierten neutrophilen Granulozyten
… They produce the fibrinolytic enzyme t-PA (tissue plasminogen-activator) and its inhibitor PAI-1 (plasminogen-activator-inhibitor-1). Our investigations of cultured human mesothelial cells show an increase of PAI-1 and a decrease of t-PA concentration under inflammatoric stimulation. We …
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Untersuchungen zur Wirkung des Hepatocyte Growth Factor (HGF) auf Humane Omentum Majus Zellen
… example provoke an ileus. Elevated levels of hepatocyte growth factor (HGF) were found in serum analyses of patients who had undergone liver surgery. In order to get insight into peritoneal wound healing, which occurs during liver regeneration, the presented study investigated on the influence …
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Vascular biology in the menstrual cycle, pregnancy and pre-eclampsia
… stimulated tissue plasminogen activator (t-PA) release, platelet activation, arterial stiffness and circulating endothelial progenitor cell (EPC) number are established indicators of vascular pathology and prognosis.
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In vivo and in vitro regulation of plasminogen activator inhibitor type-1
… to differentiate along the megakaryoblastic pathway by the addition of phorbol myristate acetate and, during this process, the cells switch from producing a mixture of active tissue plasminogen activator (t-PA) and urokinase (u-PA) to producing active u-PA alone. I performed a series of …
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Untersuchungen zum c-met/HGF-System an humanen Mesothelzellen in vitro
… inflammation or injuries to the serosa. This paper investigated whether human mesothelial cells, in vitro, expressed the c-met receptor and their sensitivity to stimulation with recombinant HGF. RT-PCR and Western Blot was used to show c-met-receptor-expression of human mesothelial cells. It …
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In vivo εφαρμογή νευροπροστατευτικών παραγόντων σε ισχιακό νεύρο επίμυος, μετά από πρόκληση ισχαιμίας/επαναιμάτωσης, και εκτίμηση του αποτελέσματος με ιστοχημικές μεθόδους
… ομάδας και των ομάδων των βιταμινών και του t-PA. Φαίνεται, λοιπόν, ότι το πειραματικό μοντέλο ισχαιμίας/επαναιμάτωσης είναι κατάλληλο για την μελέτη της σχέσης μεταξύ της οξειδωτικής κατάστασης και του αιματονευρικού φραγμού. Η προστασία του περιφερικού νεύρου, με την εφαρμογή …
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Insights Into the Dynamic Structure and Inhibitory Mechanism of Plasminogen Activator Inhibitor Type 1
… the biochemical differences between wild-type PAI-1 (wtPAI-1) and 14-1B and to infer structural and functional details about the naturally occurring inhibitor using the structural model of the stable variant as a starting point. Using conformationally-sensitive ligands, we found that the RCL of …
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The principal protease system in bovine milk
Plasmin is the principal endogenous protease in bovine milk. Distribution of overall proteolytic potential among milk fractions was determined using Coumarin Substrate as a synthetic substrate. Casein containing fractions had a higher amidolytic potential. However, preparation of casein by acid …
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Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury.
… of tissue plasminogen activator (t-PA) is the only thrombolytic therapy approved by the FDA for the treatment of acute ischemic stroke. There are no other effective treatments available so far. The discovery of new drugs and new treatments for stroke to reduce mortality and …
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