Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"t cell repertoire"”.
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P0 specific T-cell repertoire in wild-type and P0 deficient mice
… Selektionsmechanismen des P0-spezifischen T-Zell-Repertoires zu untersuchen. Dazu wurde eine Reihe von überlappenden 20-mer-Peptiden benutzt, die die gesamte Aminosäuresequenz von P0 abdeckten. Mit Hilfe dieser Peptide wurde ein sog. „Epitop-Mapping“ der H2-Ab-restringierten T-Zell-Antwort …
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AGE-RELATED GUT DYSBIOSIS ACCELERATES THYMIC INVOLUTION AND ALTERS PERIPHERAL T CELL REPERTOIRE IN DUCHENNE MUSCULAR DYSTROPHY
Emerging researches highlight a significant interplay between the immune system and skeletal muscle, particularly in the context of inflammatory muscle disorders and dystrophic conditions like Duchenne Muscular Dystrophy (DMD), as well as during the natural process of muscle regeneration. …
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Characterization of viral- and fungal-reactive CD4+ T cells in healthy and diseased
… the investigation of antigen-specific CD4+ T cell responses in the contexts of SARS-CoV2 vaccination and chronic intestinal inflammation, with focus on the roles of pre-existing T cell repertoires, antigen specificity and cross reactivity. The first study demonstrates that the quality of …
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Cytokine signaling control of naïve CD8⁺ T-cell homeostasis
… immune responses requires a large naive T-cell population with a wide diversity of target specificity. Naive CD8⁺ T-cells depend on T-Cell Receptor (TCR) and ye cytokine signals for their homeostatic survival and proliferation, but differences in sensitivity to these homeostatic signals …
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The development and function of thymic microenvironments
… the generation of a diverse and self-tolerant T-cell repertoire. Thymic epithelial cells (TEC) represent a key stromal cell type during defined stages in T cell development, yet the mechanisms regulating their development are only partly understood. An ontogenetic approach was employed to study …
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The role of idiotype-specific immunity in antigen receptor diversity
… to determine whether editing of the lymphocyte repertoire is present in an HLA-dependant manner. Data presented demonstrates a decrease frequency of CDR3-derived HLA-A2 binding peptides in HLA-A2+ donors (0.03% (SYFPEITHI) and 0.35% (BIMAS)) compared with HLA-A2- donors (0.24% (SYFPEITHI, …
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Killer Cell Immunoglobulin-Like Receptors Delineate Distinct Phenotypes and Functions in Human γδ T Cells
Human circulating γδ T cells are broadly classified into three subsets: Vδ1, Vδ2, and Vδ1/2neg populations, with the Vδ2 subset being the most abundant. In this research, I focus on the contribution and interplay of Natural Killer (NK) receptors to the γδ T cell phenotype and function, with …
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Intestinal CD4+T Cell Responses to Food
… Oral tolerance requires CD4<sup>+</sup> T cells including specifically regulatory T cells (Tregs), however the role of intestinal CD4<sup>+</sup> T cells and the T cell repertoire in a physiological response to food protein remains largely unexplored. To characterize intestinal T cell …
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Intrinsic heterogeneity in the survival and proliferation capacities of naïve CD8⁺ T cells
… within the seemingly homogeneous naive CD8⁺ T cell population in their survival and proliferation capacities. This heterogeneity is predictably marked by the surface level of CD5. NaYve CD8⁺ T cells that are also CD5hi have a greater intrinsic capacity to proliferate both in response to IL7 …
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CD4+ T cell response against food antigens in intestinal disease
… system, in particular antigen-specific CD4+ T cells, are thought to play a key role in this process, but the exact mechanisms leading to the development and maintenance, as well as the failure, of oral tolerance are still not fully understood. T cells that recognize one particular antigen are …
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Quantitative dynamics of T-cell receptor repertoires and their use for cancer patient stratification
T-cells in the adaptive immune system can recognise a vast space of potentially foreign antigens in a very specific way through their T-cell Receptors (TCR). As the genetic sequence encoding for the TCR is the result of somatic recombination, the TCR sequence varies from T-cell to T-cell, making it …
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Impact of Intratumor Heterogeneity and The Tumor Microenvironment In Shaping Tumor Evolution and Response to Therapy
… multidimensional profiling of a tumor and its cellular ecosystem we assessed spatial heterogeneity in response to ICB in metastatic melanoma and highlighted the effects of copy number alterations being associated to varied immune phenotypes. We characterized localized regions of immune …
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Phenotypic and functional analysis of the mesenchymal stromal cell compartment in the thymus
T cells are key cellular components of the adaptive immune system that play a critical role in our defense against pathogens and cancer but also contribute to pathology in the setting of chronic inflammation and autoimmunity. The thymus constitutes the body's major T cell production site, where …
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Bone Marrow Derived Progenitor Cells and Their Contributions to the Thymic Stroma
… development and selection of a self-tolerant T cell repertoire. In paradox to its critical functions for the adaptive immune response, the thymus undergoes a profound age associated decline beginning in early adult life resulting in significant decline in T-cell function.Thymic epithelial cells …
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Enhancing Adoptive Cell Therapy By Augmenting Fitness and Anti-Tumor Function of Tumor-Infiltrating Lymphocytes
… vivo</em> approach to activate tumor-specific T cells, albeit in some cases, this modality does not create a sufficiently robust anti-tumor response. Thus, <em>ex vivo </em>approaches employing manipulation of immune cells, such as Adoptive Cell Therapy (ACT) using autologous Tumor-infiltrating …
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Novel peptide antigens provide insights into the recognition process by T cells
… described here involve molecular aspects of T cell recognition and the reactivity of T cell receptors with novel peptide antigens. The first study (Chapter 2) described a collection of novel peptide antigens for a single T cell receptor and their diverse requirements for the co-receptor CD8. …
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Characterization of Skin Immune Reactions Induced by the Contact Sensitizer Diphencyprone in Healthy Volunteers and Metastatic Melanoma Patients
… immunology. Furthermore, we used comprehensive T cell receptor sequencing to show that the immune reactions induced by DPCP are polyclonal, and therefore suggests that the induced inflammation is not due to a single antigen. Also, different individuals expanded different T cell clones in response …
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On Thymic Regulatory T-Cell Ontogeny
<p>Regulatory T (Treg) cells play a pivotal role in maintaining immune homeostasis and preventing autoimmunity. Like most T cells, Treg development occurs primarily in the thymus, where T-cell precursors undergo a series of developmental stages, including double-negative (DN), double-positive (DP), …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… characteristics of the sustained rise of intracellular Ca2+ ([Ca2+]i) and Na+ ([Na+]i), observed in pre-selection CD4+CD8+ (double-positive, DP) thymocytes when stimulated with dextran sulfate (DxS) and explores several candidate channels that may be involved in this rise. . This [Ca2+]i rise …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… characteristics of the sustained rise of intracellular Ca2+ ([Ca2+]i) and Na+ ([Na+]i), observed in pre-selection CD4+CD8+ (double-positive, DP) thymocytes when stimulated with dextran sulfate (DxS) and explores several candidate channels that may be involved in this rise. . This [Ca2+]i rise …
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