Global ETD Search
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Showing 1 to 4 of 4 for “"t(1;19)"”.
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Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor
The t(1;19) chromosomal translocation is present in 5% of acute lymphoblastic leukemia (ALL) cases and leads to expression of the oncogenic transcription factor, E2A-PBX1. Although t(1;19) is exclusively associated with pre-B ALL in clinical cases, murine models produce myeloid or T-lymphoid …
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Molecular analysis of transcriptional properties of Pbx1 and E2a-Pbx1
E2a-Pbx1 is an oncogene formed by the t(1;19) chromosomal translocation, which is found in 20% of pediatric pre-B acute lymphoblastic leukemias. E2a-Pbx1 joins exons encoding the amino-terminal transactivation domain of E2a with those encoding the carboxyterminal homeodomain of Pbx1, which binds …
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Examining the effect of CBP on the E2A-PBX1 and HOXB4 interaction
The E2A-PBX1 fusion gene results from the t(1;19) chromosomal translocation that is found in 25% of pre-B-cell cases of acute lymphoblastic leukemia (ALL). The resulting encoded product contains the transactivation domains of E2A, a Class I basic helix-loop-helix transcription factor, and most of …
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Characterization of Transcription Factor-Coactivator Complexes in Acute Lymphoblastic Leukemia
… as a result of the chromosomal translocation 1;19. E2A-PBX1 contains the activation domains of E2A and most of the PBX1 protein, including the DNA-binding homeodomain. These structural features suggest a hypothetical oncogenic model in which E2A-PBX1 binds DNA, recruits transcriptional …